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LMU 205 – Your Genes Are Not Your Destiny: How Lifestyle Choices Can Reduce the Risk of Colon Cancer

LMU-205

Your Genes Are Not Your Destiny: How Lifestyle Choices Can Reduce the Risk of Colon Cancer

Source: The American Journal of Clinical Nutrition (April 2021)

Lifestyle Medicine Update (June 7, 2021)

Introduction:

For decades, the scientific community held high hopes that the Human Genome Project would unlock the secrets behind age-related degenerative diseases like Alzheimer’s and various cancers. The prevailing belief was that specific gene mutations would be pinpointed as direct causes of these conditions. However, the reality turned out to be quite different. A study published in the April 2021 issue of the American Journal of Clinical Nutrition sheds light on this paradigm shift, illustrating that our genes alone are not the sole culprits behind diseases like colon cancer. Instead, it’s the intricate interplay between our genes and lifestyle choices that significantly influences our health outcomes.

A Complex Genetic Landscape

Contrary to initial expectations, the Human Genome Project revealed that age-related diseases, including Alzheimer’s and certain types of cancer, are not triggered by a single gene mutation but rather by a complex web of gene variants. These variants interact in ways that elevate the risk of developing these conditions. The intricacies of these gene interactions remain a subject of ongoing research, and scientists are still unravelling how they influence each other.

To further complicate matters, not everyone carrying these gene variants succumbs to diseases like Alzheimer’s or colon cancer. Instead, an individual’s diet, physical activity, and other lifestyle factors play a pivotal role in mitigating or exacerbating these risks. The study highlighted here, focusing on colon cancer, exemplifies this intriguing relationship between genes and lifestyle choices.

Reducing Colon Cancer Risk Through Lifestyle Choices

In this extensive study involving nearly 350,000 participants as part of the UK Biobank Study, researchers delved into the genetic underpinnings of colon cancer. They assessed participants based on their genetic risk scores for the disease, determined by the presence of multiple gene variants associated with an elevated risk of colon cancer.

What the researchers discovered was remarkable: individuals with high genetic risk scores for colon cancer, who also boasted high Healthy Lifestyle Scores, exhibited a remarkable 40% reduction in their risk of developing the disease compared to those with identical genetic risk factors but less healthy lifestyle scores. In essence, it was a compelling revelation that genes do not act in isolation to predetermine one’s fate with colon cancer or many other degenerative illnesses.

Genes and Lifestyle: A Dynamic Partnership

Instead of genes acting as deterministic forces, it’s the intricate dance between our genetic makeup and lifestyle choices that either triggers or prevents the onset of degenerative conditions. In the context of the UK Biobank Study, participants with high genetic risk scores for colon cancer benefited immensely from lifestyle practices that included increased physical activity, healthier body shape measurements with lower body fat, avoidance of processed and red meat, higher consumption of vegetables and fruits, limited or no alcohol intake, and refraining from smoking.

To put it simply, individuals with less healthy lifestyle practices, even when carrying high genetic risk factors, faced a 40% higher risk of developing colon cancer.

Your Wellness Game Plan Matters

The key takeaway from this research is clear: your genes are not your destiny. Your wellness game plan, comprising dietary choices and lifestyle patterns, significantly influences your overall health and longevity. By making mindful decisions about what you eat and how you live, you can take charge of your well-being and enhance your healthy life expectancy—the number of years during which you enjoy a highly functioning body and mind.

In essence, the intricate tapestry of your health is woven from both genetic threads and the choices you make in life. So, remember that your actions today can shape your health tomorrow, proving that your genes are not the sole dictators of your destiny.

Reference:

Jungyoon Choi, Guochong Jia, Wanqing Wen, Xiao-Ou Shu, Wei Zheng. [Healthy lifestyles, genetic modifiers, and colorectal cancer risk: a prospective cohort study in the UK Biobank. The American Journal of Clinical Nutrition, 2021; 113 (4)](https://academic.oup.com/ajcn/article-abstract/113/4/810/6155851?redirectedFrom=fulltext)

Eat Smart, Live Well, Look Great,

Dr. Meschino

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU – 177 Unlocking the Power of Diet and Lifestyle: Shielding Against Colon Cancer

LMU-177

LMU – 177 Unlocking the Power of Diet and Lifestyle: Shielding Against Colon Cancer

Source: British Medical Journals “Gut” (September 2020)

Lifestyle Medicine Update (October 17, 2020)

Introduction:

Colon cancer, the second leading cause of cancer-related deaths in most developed nations, wields a significant impact on public health. Over the years, an increasing body of research has pointed to the undeniable influence of diet and lifestyle factors on the development of this malignancy. In this article, we delve into a compelling study published in the British Medical Journal, “Gut,” which meticulously scrutinizes the link between diet, lifestyle, and colon cancer.

The Foundation of Colon Cancer Risk

Before we dive into the protective and detrimental aspects of diet and lifestyle, it’s crucial to understand the foundational role they play in the risk of colon cancer. Numerous studies have unequivocally demonstrated that our daily choices significantly influence our susceptibility to this formidable disease.

Dietary Heroes: Magnesium, Folic Acid, Dairy, Fiber, and More

This comprehensive analysis uncovered a lineup of dietary superheroes, each armed with the power to shield against colon cancer. Magnesium, with an intake of at least 255 mg/day, emerged as a formidable defender, reducing the risk of colon cancer by a substantial 23%. Equally potent was the B-vitamin folic acid, showing its protective might with a 12-15% risk reduction. The stalwart presence of dairy products, associated with a 13% to 19% lower risk, can be attributed to their calcium content, as corroborated by other studies.

Dietary Fiber and Plant-Based Potency

Fiber, often hailed as a nutritional champion, demonstrated its prowess by contributing to a striking 22%-43% reduction in colon cancer risk. However, the real star of the show was fruit and vegetable intake, linked to a remarkable up to 52% lower risk[^1^]. Furthermore, for every additional 100 g/day (3.5 ounces) increase in intake, the protective effect gained momentum. The consumption of soybeans and soy products, spanning all varieties, was no less heroic, presenting an 8-15% decrease in the risk of colon cancer.

The Dark Side of Diet: Red Meat and Processed Meats

As with every epic saga, there is a dark side to this narrative. Red meat and processed meats emerge as antagonists in the battle against colon cancer, driving a 12-21% increase in risk. The ominous nature of this threat becomes even more apparent when considering a dose-dependent effect. Each additional 100 gm/d of red meat consumed escalates the risk, underscoring the dire consequences of unchecked consumption.

Alcohol – A Double-Edged Sword

The study’s findings underline the ambivalent nature of alcohol consumption concerning colon cancer risk. Even modest alcohol intake, ranging from 1-2 drinks per day, ushers in an elevated risk. This revelation adds nuance to our understanding of the relationship between alcohol and colon cancer, urging caution even among light to moderate drinkers.

A Synthesis of Established Wisdom

The revelations uncovered in this extensive review serve as a poignant reminder of the pivotal role our dietary and lifestyle choices play in preventing the second most prevalent cause of cancer-related deaths: colorectal cancer. While early detection through colonoscopies and fecal occult blood analysis remains crucial, proactive individuals dedicated to wellness should also be fervently committed to implementing practices that proactively ward off colon polyps and malignant tumours. The insights gained from this study offer a refined perspective on how to fine-tune our colon cancer prevention strategies.

Conclusion: Empowering the Fight Against Colon Cancer

In conclusion, the symbiotic relationship between diet, lifestyle, and colon cancer risk is undeniable. The findings elucidated in this study illuminate a path toward empowerment. By harnessing the protective potential of magnesium, folic acid, dairy, fiber, plant-based foods, and soy products, and vigilantly moderating red and processed meat intake as well as alcohol consumption, individuals can actively fortify their defences against colon cancer. As we navigate the complex terrain of colon cancer prevention, each dietary choice and lifestyle decision becomes a weapon in our arsenal to combat this formidable adversary.

Reference:

  1. Chapelle N, Martel M et al. *Recent advances in clinical practice: colorectal cancer chemoprevention in the average-risk population.* British Medical Journals – Gut. September 2020                                                                                                                                                                              [Read more](https://gut.bmj.com/content/early/2020/09/08/gutjnl-2020-320990)
 
Eat Smart, Live Well, Look Great,
 

Dr. Meschino

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 120 – Unmasking the Connection: High-Fat Diet and Colon Cancer Risk in a Genetic Landscape

LMU-120

LMU 120 – Unmasking the Connection: High-Fat Diet and Colon Cancer Risk in a Genetic Landscape

Source: Journal “Cell” (February 2019)

Lifestyle Medicine Update (February 27, 2019)

Introduction:

The whispers of a growing concern have turned into resounding alarms within the realm of cancer research. Colorectal cancer, a formidable adversary, has begun to rear its head in a younger population, sending shockwaves through the medical community. A disquieting revelation from the American Cancer Society highlights a rising trend in deaths from colorectal cancer among individuals under the age of 55. Amidst the disconcerting statistics, a beacon of understanding emerges, illuminating a potential key factor behind this unsettling surge. In the pages of the February 2019 issue of the journal “Cell,” researchers unveil a revelation that bridges genetics and diet in the development of colorectal cancer.

Genetic Risk and Dietary Triggers: A Disturbing Alliance

The stage for this revelation is set with the APC gene, an integral player in the realm of colon health. The APC gene, responsible for orchestrating regulated cell division within the colon, carries a sinister secret. A genetic defect within this gene paves the way for an increased risk of colon cancer. Yet, the story doesn’t end here. The complexity of genetics unveils a twist—while the APC gene defect is a loaded gun, the introduction of a high-fat diet is the trigger that ignites the devastating cascade of colon cancer development.

The Crucial Culprit: High-Fat Diet

The groundbreaking study in the journal “Cell” speaks volumes about the intimate connection between genetics and diet. Under experimental conditions, animals harboring an APC genetic mutation were fed a high-fat diet. The results painted a stark picture—colon tumors, both benign and malignant, flourished in response to the high-fat diet. In a contrasting scenario, animals with the same genetic mutation but fed a lower fat diet remained unscathed by the threat of colon tumors. The verdict was clear: the APC gene mutation set the stage, but it was the high-fat diet that took center stage as the driving force behind colon cancer development.

Deciphering the Mechanism: Bile Acids and Colon Stem Cells

To uncover the intricate mechanism behind this alliance, the researchers dived deeper into the molecular landscape. A high-fat diet was found to amplify the secretion of bile acids into the intestinal tract. These bile acids, in turn, exerted their influence on a signalling protein within colon stem cells. A crucial protein known as the FXR was inhibited by the action of bile acids. This inhibition created fertile ground for cancer stem cells to propagate uncontrollably, especially in the absence of the check imposed by the APC tumor suppressor gene. The story of cancer unfolded through this interplay, revealing a pivotal chapter in the journey of its genesis.

Unveiling the Preventive Strategies

The revelation serves as a clarion call, reiterating the significance of preventive strategies in the face of colorectal cancer. A gene mutation may set the stage, but it is lifestyle and dietary choices that take the reins. The consumption of a high-fat diet, emblematic of the North American and Western diets, emerges as a central culprit. From high-fat meats to deep-fried temptations, from creamy salad dressings to coconut oil-laden pastries, the high-fat diet contributes significantly to the emergence of colon cancer. This revelation gains greater weight as we witness the unsettling rise of colon cancer among individuals below the age of 55.

Charting a Path to Resilience

The path forward unfolds with clarity—the power to prevent colon cancer resides within our choices. Embracing a healthier dietary landscape becomes the cornerstone. By limiting the intake of detrimental fats, we place ourselves on a trajectory towards resilience. The unsettling statistics can be challenged, and colon cancer’s reach curtailed, through a conscious commitment to well-being. Beyond dietary choices, routine colonoscopy assessments after the age of 50 serve as guardians against the emergence of benign tumors that could evolve into malignant colon cancer.

Epilogue: A Tapestry of Choices

As we traverse the landscape of cutting-edge research, we find ourselves at the crossroads of genetic predisposition and dietary choices. The canvas of human health is painted by intricate strokes—the harmony between genetics and lifestyle. The revelation that a high-fat diet can function as the catalyst in the emergence of colon cancer unveils the importance of redefining our relationship with food. It underscores the potential for empowered choices in sculpting our well-being. Let us heed this revelation as a guiding light, steering us towards vitality and longevity.

References:

1. Ting Fu, Sally Coulter, Eiji Yoshihara, Tae Gyu Oh, Sungsoon Fang, Fritz Cayabyab, Qiyun Zhu, Tong Zhang, Mathias Leblanc, Sihao Liu, Mingxiao He, Wanda Waizenegger, Emanuel Gasser, Bernd Schnabl, Annette R. Atkins, Ruth T. Yu, Rob Knight, Christopher Liddle, Michael Downes, Ronald M. Evans. FXR Regulates Intestinal Cancer Stem Cell Proliferation. Cell, 2019; 176 (5): 10.1016/j.cell.2019.01.036

Eat smart, live well, look great,

Dr. Meschino

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 109 – The Weighty Connection: Unravelling Colon Cancer Risk

LMU-109

LMU 109 – The Weighty Connection: Unravelling Colon Cancer Risk

Source: Journal: Cancer Epidemiology Biomarkers & Prevention (October 2018)

Lifestyle Medicine Update (October 19, 2018)

Introduction

In the realm of health, the intricate interplay between weight and cancer has intrigued researchers for years. On October 11, 2018, the journal Cancer Epidemiology Biomarkers & Prevention unveiled a research paper that delves into the link between excess weight and the heightened risk of developing colon cancer. This study contributes vital pieces to the puzzle, offering insights into the mechanisms that tether weight, inflammation, and cancer.

Inflammation’s Trail: Tracking the Culprits

As our understanding of health deepens, so does the realization that inflammation often fuels the fires of disease. The researchers of this study focused their attention on two inflammatory chemicals—Tumor Necrosis Factor-alpha (TNF) and Interleukin-6 (IL-6)—that have been implicated in promoting inflammation and cancer. The nexus between weight and these inflammatory markers emerges as a critical connection in the cancer equation.

The Study’s Scope: Colon Cells Under the Microscope

The question at hand was whether the link between excess weight and inflammation found a haven within colon cells. To unveil this mystery, scientists meticulously examined colon cells from two groups: 16 lean individuals and 26 moderately overweight participants. In the context of Body Mass Index (BMI), the latter group fell within the moderately overweight category, boasting a BMI at or above 34. The study’s findings reverberated with significance: the colon cells of overweight individuals exhibited a staggering 3-fold increase in TNF levels and a 1.6-fold rise in IL-6 levels compared to lean counterparts.

The Amplifying Effect: Weight’s Role in Cancer Aggression

The connection between TNF, IL-6, and cancer becomes increasingly riveting as one delves deeper into the research. Not only do these inflammatory agents play a pivotal role in cancer development, but they also perpetuate cancer’s aggressive progression. As cancer cells come into existence, TNF and IL-6 propel their growth, replication, and metastasis—a menacing cocktail that amplifies cancer’s impact. The study’s findings unveil how these chemicals serve as key drivers in the intricate dance of cancer development and progression within the body.

Inflammation Unveiled: The Chronic Inflammation-Cancer Nexus

The study’s revelations also bridge the gap between chronic inflammation and cancer risk. The well-established association between chronic inflammation and cancer risk gains further traction as TNF and IL-6 take center stage. Not only do they serve as promoters of inflammation, but they also perpetuate the cycle that heightens cancer susceptibility. The intricate interplay between inflammation and cancer risk finds a compelling partner in TNF and IL-6.

A Call to Action: Weight Management and Cancer Prevention

As the puzzle pieces fall into place, the implications for public health are undeniable. In regions like North America, where colorectal cancer ranks as the third most common cancer and the second leading cause of cancer-related death across genders, insights like these take on heightened significance. With the American Cancer Society reporting that colorectal cancer’s lifetime risk is 1 in 22 for men and 1 in 24 for women, the gravity of the issue becomes palpable. However, the realm of hope exists as well: reports suggest that up to 90% of colon cancer cases are avoidable through dietary and lifestyle practices.

Conclusion: A Deeper Dive into the Weight-Cancer Connection

The study published in the journal Cancer Epidemiology Biomarkers & Prevention unfolds as a vital chapter in the narrative of cancer prevention. Its findings, linking weight, inflammation, and colon cancer, echo the importance of maintaining a healthy weight. As colorectal cancer continues to pose a formidable challenge to public health, awareness of these linkages and the implementation of dietary and lifestyle strategies emerge as a beacon of hope. The quest to unravel the tapestry of cancer and offer pathways to prevention remains an ongoing journey.

References:

  1. Main Reference:

    2. Pfalzer AC, Leung K, Crott JW, Kim SJ, Tai AK et al. Incremental elevations in TNF-alpha and IL-6 in the human colon and precancerous changes in the mucosal transcriptome accompany adiposity. Cancer Epidemiology Biomarkers & Prevention. DOI: 10.1158/1055-9965.EPI-18-0121 Oct 11, 2018.

    [Read the full study here] (http://cebp.aacrjournals.org/content/early/2018/10/11/1055-9965.EPI-18-0121)

  2. IL-6 and Cancer:

    3. Kumari N et al. Role of interleukin-6 in cancer progression and therapeutic resistance. Tumour Biol. 2016. 37(9):11553-11572

    [Read the study here] (https://www.ncbi.nlm.nih.gov/pubmed/27260630)

  3. Colon Cancer Statistics:

    4. Science Daily: Inflammatory proteins in colon increase incrementally with weight:

    [Read more here] (https://www.sciencedaily.com/releases/2018/10/181010105720.htm)

Eat Smart, Live Well, Look Great,

Dr. Meschino

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 100 – Unveiling the Sweet Connection: High Glycemic Diets and Colorectal Cancer Risk

LMU-100

LMU 100 – Unveiling the Sweet Connection: High Glycemic Diets and Colorectal Cancer Risk

Source: American Journal of Clinical Nutrition (August 2018)

Lifestyle Medicine Update (August 17, 2018)

Introduction

The intricate tapestry of health is woven from an intricate interplay of factors, a dance between choices and consequences. In this intricate choreography, a significant study emerged in August 2018, published in the American Journal of Clinical Nutrition. This study unfurled a narrative of paramount importance, connecting the dots between dietary habits, insulin response, and the risk of a menacing adversary: colorectal cancer. By merging the threads of two landmark studies—the Health Professionals Follow-Up Study and the Nurses’ Health Study—this research cast light on a pressing concern: the glycemic potential of diets and their insidious link to the realm of colorectal cancer.

Unravelling the Threads: The Study’s Genesis

Stepping onto the stage of scientific exploration, the study showcased a pioneering blend of data. Fuelled by the Health Professionals Follow-Up Study’s expansive journey into the lives of over 46,000 male health practitioners and the Nurses’ Health Study’s dedicated pursuit of over 74,000 female nurses, the canvas stretched over decades. The tapestry of inquiry spanned from 1984 to 2012, an intricate narrative encompassing the dietary rhythms and health trajectories of these dedicated individuals.

Glycemic Potential: A Glimpse into Colorectal Cancer Risk

As the narrative unfolded, the crux of the investigation emerged—the glycemic nature of the diets embraced by these health warriors. The Empirical Dietary Index for Hyperinsulinemia (EDIH), a gauge of glycemic response, took center stage. This index cast its gaze upon the potential for blood sugar elevation and insulin secretion provoked by each individual’s dietary choices. The correlation between these glycemic footprints and the spectre of colorectal cancer was poised for revelation.

The Resounding Echo: Diet’s Role in Colorectal Cancer Risk

As the findings were laid bare, a crescendo reverberated—an unmistakable link between high glycemic diets and colorectal cancer risk. The male participants bearing the weight of high glycemic diets stood before a 33% heightened risk of colon cancer, a striking contrast to their counterparts who adhered to the sanctuary of low glycemic dietary patterns. Women too shared this sombre fate, as those consuming high glycemic diets faced a 22% amplified risk of colon cancer compared to their low glycemic adherents. The tale these statistics wove was not unfamiliar—previous chapters of research had already etched the correlation between sugary and starchy diets, surging blood sugars, insulin overdrive, and the spectre of colorectal cancer.

The Unveiling of Insulin’s Dual Role: A Mediator of Risk

As the curtains of insight drew back, a dual role of insulin emerged—one of promoting rapid cell division in the lining of the colon and rectum. A perilous dance ensued, the cells of the gastrointestinal tract thrust into a frenetic rhythm. More rapid cell division paved the path for genetic mutations to flourish, setting the stage for the ominous transformation into cancerous entities. As the researchers illuminated this intricate choreography, they underscored the pivotal role of insulin in influencing the march towards colorectal cancer.

Crafting a Prelude to Prevention: The Holistic Wellness Ensemble

Amidst the tapestry of findings, a refrain emerged—a clarion call for prevention, an arsenal of strategies designed to disarm the threat of colorectal cancer. Assembling a symphony of wellness, the clarion call bore the promise of significant reduction in risk. The list of strategies unveiled a roadmap—a roadmap to resilience:

  1. Reducing high-fat animal products, trans-fats, deep-fried foods, and processed meats.
  2. Incorporating calcium-rich foods or supplements.
  3. Sustaining optimal vitamin D levels.
  4. Ensuring sufficient B-vitamin, folic acid intake.
  5. Moderating or eliminating alcohol consumption.
  6. Avoiding smoked, charred, or high-temperature-cooked meats.
  7. Steering clear of nitrates and nitrites in preserved foods.
  8. Embracing dietary fiber.
  9. Maintaining an ideal body weight.
  10. Engaging in regular physical exercise.
  11. Abandoning the smoking habit.

The Symphony of Lifelines: A Vibrant Conclusion

In the grand finale of this intricate dance, the researchers’ voices harmonized—a symphony of lifelines resonated. This comprehensive ensemble, a chorus of nutritional wisdom and lifestyle resilience, heralded a path to optimized longevity—a roadmap illuminated by reduced risk of colon cancer and a myriad of degenerative diseases. As the curtain fell on this chapter, the researchers’ parting words echoed—a resounding call for vigilance, for colo-rectal cancer’s mantle as the second leading cause of cancer death necessitates a profound embrace of prevention. In a world where choices echo through the corridors of health, this study stands as a sentinel, guiding the way to a future where the risk of colon cancer is written into the sands of history.

References

  1. Tabung F, Wang, W, Fung, T, et al. (2018). Association of dietary insulinemic potential and colorectal cancer risk in men and women. Am J Clin Nutri. [Link] (https://academic.oup.com/ajcn/article-abstract/108/2/363/5036567?redirectedFrom=fulltext)
  2. C-peptide as a Marker of Insulinemic Response to Diet. [Link] (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1829170/)
  3. Assessing Insulin Response. [Link] (https://www.ncbi.nlm.nih.gov/books/NBK278954/)

Eat Smart, Live Well, Look Great,

Dr. Meschino

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 94 – Sunshine Vitamin Shields Against Colorectal Cancer: The Vitamin D Revelation

LMU-94

LMU 94 – Sunshine Vitamin Shields Against Colorectal Cancer: The Vitamin D Revelation

Source: Journal of the National Cancer Institute (2018)

Lifestyle Medicine Update (July 7, 2018)

Introduction

Colorectal cancer, the third leading cause of cancer-related deaths in North America and many developed nations, casts a shadow over countless lives. However, the tides are turning as groundbreaking research delves into the protective potential of a humble nutrient: vitamin D. A 2018 study published in the Journal of the National Cancer Institute has unveiled compelling evidence, propelling vitamin D into the spotlight as a formidable guardian against colorectal cancer. In this exploration, we journey through the study’s revelations, spotlighting the profound impact of optimal vitamin D levels on cancer prevention.

A Link Between Lifestyle and Colorectal Cancer

Colorectal cancer’s intricate dance with nutrition and lifestyle comes to the forefront. Beyond genetics, faulty nutrition and lifestyle factors weave the tapestry of this ailment. Inadequate physical activity, excess weight, smoking, and heavy alcohol consumption emerge as key players. A staggering 70-90% of cases could potentially be thwarted through prudent dietary and lifestyle choices.

The Vitamin D Vanguard: Illuminating the Role

Among various nutritional factors, the spotlight has long shone on vitamin D’s potential in preventing colorectal cancer. While preliminary studies hinted at the link, the quest for definitive data persisted. Enter a comprehensive 2018 study that amalgamated insights from 17 cohort studies, enrolling over 5,000 colorectal cancer cases and 7,000 controls. The amalgamation of these studies, tracking 12,000 individuals over an average follow-up of 5.5 years, unfurled a revelation. Individuals commencing with a blood vitamin D level exceeding 50-63 nmol/L (20 – 25 ng/mL) enjoyed a striking 22% reduction in colorectal cancer risk, in comparison to those falling within the same range.

Vitamin D Beyond Osteoporosis: A Colorectal Ally

Vitamin D’s reputation as an osteoporosis defender is well-known, advocating for blood levels between 50-63 nmol/L (20-25 ng/mL). However, the quest for colorectal cancer prevention demands a higher threshold. Achieving an additional 22% reduction in colorectal cancer risk calls for maintaining a year-round vitamin D level beyond this range. To this end, experts advise aiming for a blood vitamin D level of at least 85 nmol/L (34 ng/mL), with higher levels potentially beneficial for high-risk individuals.

Unveiling Vitamin D’s Anti-Cancer Arsenal

Venturing into the realm of scientific intricacies, vitamin D’s multi-faceted role in combating colorectal cancer emerges. Evident through human and experimental studies, its anti-cancer prowess encompasses various dimensions:

  1. Slowing Cell Division: Vitamin D’s hand slows the frantic pace of colon cell division, reducing genetic errors and the risk of cancerous transformation.
  2. Encouraging Cellular Death: Emerging cancer cells face an adversary in vitamin D, prompting programmed cell death or apoptosis.
  3. Nurturing Maturity: Vitamin D’s touch guides emerging cells towards full maturity, a process known as cellular differentiation, which curbs cancer susceptibility.
  4. Blocking Cancer Pathways: Vitamin D erects barriers against the Wnt pathway, a crucial player in colon cancer development.
  5. Taming Inflammation: Vitamin D’s anti-inflammatory prowess stands as a sentinel against inflammation-associated cancer risks.
  6. Strengthening Immunity: The vitamin’s supportive hand uplifts immune function, a pivotal aspect of cancer prevention.
  7. Countering Metastasis: Vitamin D reins in the synthesis of factors driving colon cancer metastasis, such as VEGF, curbing new blood vessel formation to sustain tumors.

A Clarion Call for Public Health Guidelines

The implications of the 2018 study resonate deeply, urging individuals and health agencies to reevaluate guidelines. With colorectal cancer’s menacing shadow, optimizing vitamin D levels emerges as a formidable strategy. Experts echo the call to maintain a blood vitamin D level above 63 nmol/L (25 ng/mL). Achieving this feat involves embracing nourishing practices, including consuming fish regularly, integrating vitamin D-fortified low-fat dairy products, and supplementing vitamin D. While sunlight exposure contributes, concerns about skin cancer risk make dietary and supplemental sources the preferred routes.

Conclusion

As science unravels the mysteries of cancer prevention, vitamin D emerges as a beacon of hope in the fight against colorectal cancer. The 2018 study’s findings pierce through the haze, revealing a tangible path towards safeguarding health. With an enhanced understanding of vitamin D’s profound anti-cancer effects, individuals are empowered to chart a course towards a brighter, healthier future. As public health guidelines undergo transformation, the chapter of colorectal cancer takes a turn towards hope and resilience, with vitamin D as its steadfast ally.

References

McCullough ML, Zoltick ES, Weinstein SJ, Fedirko V, Wang M et al. Circulating vitamin D and colorectal cancer risk: An international pooling project of 17 cohorts. JNCI. June 2018

[Link] (https://academic.oup.com/jnci/advance-article-abstract/doi/10.1093/jnci/djy087/5035027?redirectedFrom=fulltext)

Eat Smart, Live Well, Look Great

Dr. Meschino

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 89 – The Dietary Connection to Cancer: Decoding the Link between High-Fat Diet, Obesity, and Tumor Initiation

LMU-89

LMU 89 – The Dietary Connection to Cancer: Decoding the Link between High-Fat Diet, Obesity, and Tumor Initiation

NMU 89 – How the High-fat North American Diet Shown to Initiate Colon, Breast and Pancreatic Cancer

Lidestyle Medicine Update (May 5, 2018)

Introduction:

The intricate interplay between diet, obesity, and cancer continues to bewilder researchers and health enthusiasts alike. Amidst the labyrinthine web of factors, a remarkable study emerged, shedding light on the perplexing connection between the typical high-fat North American diet, obesity, and the elevated risk of specific cancers. Published in the esteemed journal Cell Reports in April 2018, this study unveils a trail of insights that could rewrite our understanding of cancer initiation and progression.

The Lurking Threat: Colon, Breast, and Pancreatic Cancer

Colon cancer, breast cancer, and pancreatic cancer loom large as formidable adversaries on the global health horizon. With colon cancer ranking as the second leading cause of cancer death, breast cancer gripping women’s lives with its stealthy clutches, and pancreatic cancer leaving a trail of despair with its grim prognosis, the stakes are undeniably high.

The Unravelling: A Journey through Cancer Development

The narrative of cancer is woven through stages, each unveiling a different facet of the enigmatic disease. The initiation stage marks the birth of a cancer cell—a transformation from normalcy to malignancy. This nascent malignant cell may lie dormant, biding its time, or sprout into a full-fledged tumor. This pivotal moment, known as the tumor promotion stage, propels the narrative into one of proliferation and progression. Metastasis, the bittersweet dance of cancer cells through the body’s corridors, adds a sinister layer to the tale. Amidst this intricacy, questions lingered—how does a high-fat diet, coupled with obesity, trigger the genesis of cancer?

Epithelial Defence Against Cancer (EDAC): A Guardian Unveiled

In the midst of these queries, the study unfurled a groundbreaking revelation—the ability of normal colon, breast, and pancreatic cells to sense the emergence of malignant cells in their vicinity. Dubbed “epithelial defence against cancer” (EDAC), this process harnessed the power of healthy cells to stand as silent sentinels against impending malignancy. An orchestra of anti-tumor activity unfolded, orchestrated by these vigilant guardians. Yet, obesity and the habitual consumption of a high-fat diet cast a pall over this defensive prowess.

The Fat Culprits: Saturated Fats and Linoleic Acid

The study spotlighted certain fats as the orchestrators of this subversion—saturated fats and omega-6 fat linoleic acid emerged as the villains. These fats held the capacity to disarm the guardian cells, rendering them powerless against the burgeoning malignant cells. Linoleic acid, notorious for constituting 7% of the North American diet, emerged as a prime culprit. Vegetable oils, rich repositories of this fat, beckoned for alternatives—olive oil, canola oil, and the protective embrace of flaxseed oil, abundant in omega-3 fat alpha-linolenic acid.

A Symphony of Inflammation and Energy

The narrative unfolded to reveal more layers—high-fat diets intertwined with inflammation, birthing a dance of inflammatory fibroblasts and macrophage cells. Omega-6 fat’s role in the production of the notorious prostaglandin series-2 further fuelled the flames of cancer development. The stage was set—a symphony of energy production, metabolic survival, and the intricate dance of cancer initiation played out on the cellular canvas.

The Remarkable Anomaly: Lung Cancer

The study’s pages bore witness to an intriguing anomaly—a high-fat diet’s inability to hinder lung cells’ pursuit of eradication against malignant cells. Here, the link between obesity, high-fat diet, and lung cancer remained tenuous, evoking questions that nudged at the peripheries of understanding.

A Glimpse into the Future: Cancer Preventive Medicine

As the study’s tapestry unfurled, it beckoned us to glimpse into the future—cell competition and cancer preventive medicine standing intertwined. The realms of obesity and diet, once entwined with the mysteries of cancer initiation, now stood illuminated by the beacon of EDAC and its intricate dynamics.

Conclusion: Navigating the Path Forward

With this revelation, the compass of cancer research takes a new bearing. The pages of Cell Reports in April 2018 stand as a testament to the intricate dance of cellular defence, the subversion orchestrated by fats, and the symphony of inflammation and energy that weave the narrative of cancer initiation. As the journey to decode the enigma of cancer continues, this study offers a vital thread to weave into the tapestry of cancer prevention and holistic well-being.

References

1. Sasaki A, Nagatake T, Egami R et al. Obesity suppresses cell-competition-mediated apical elimination of RasV-12-transformed cells from epithelial tissues. Cell Reports, vol 23, issue 4. P:974-982. April 2018. 

[DOI](https://www.cell.com/cell-reports/fulltext/S2211-1247(18)30480-7)

Eat Smart, Live Well, Look Great

Dr. Meschino

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 81 – Unlocking the Link: How Dietary Cholesterol Fuels Colon Cancer Development

LMU-81

LMU 81 – Unlocking the Link: How Dietary Cholesterol Fuels Colon Cancer Development

Source: Journal Cell Stem Cell (January 2018)

Lifestyle Medicine Update (January 31, 2018)

Introduction

In the intricate realm of human health, the impact of dietary choices continues to captivate researchers and ignite discussions. One of the long-standing debates revolves around the role of dietary fats, particularly animal fats, in influencing the risk of colon cancer. Colon cancer, the second leading cause of cancer-related deaths in developed countries, has consistently piqued the interest of scientists due to its multifaceted origins and impact. For years, studies have pointed to a correlation between high animal fat consumption (excluding fish) and elevated colon cancer rates. Unravelling the intricacies of this relationship, researchers have delved into the mechanisms that underlie the association between animal fat consumption and colon cancer risk. Moreover, recent breakthroughs have uncovered the role of dietary cholesterol as a key player in this intricate puzzle, shedding light on the direct link between cholesterol intake and colon cancer development.

Animal Fat Diet and Colon Cancer: Bridging the Connection

A mounting body of evidence over the years has established a compelling connection between a diet rich in animal fats (excluding fish) and an increased susceptibility to colon cancer. While fish, a source of beneficial omega-3 fatty acids, appears to buck this trend, other sources of animal fat have been implicated in promoting the development of colon cancer. Researchers have dedicated extensive efforts to deciphering the mechanisms that drive this association. Intriguingly, it has been observed that the consumption of high levels of animal fats can trigger the production of secondary sterols and provoke alterations in the gut microflora, both of which have been linked to the progression of colon cancer. These findings open a window into the intricate interplay between dietary choices and the delicate balance of the human gut ecosystem.

Cholesterol: The Silent Culprit

As researchers delved deeper into the labyrinthine landscape of colon cancer development, an intriguing figure emerged on the scene: cholesterol. Beyond its notorious reputation as a cardiovascular risk factor, cholesterol has now been implicated in the realm of colon cancer. A groundbreaking study published in the journal Cell Stem Cell in January 2018 forged a crucial link between dietary cholesterol and the mechanics of colon cancer initiation. What set this study apart was its revelation of the precise mechanism through which dietary cholesterol exacerbates the risk of colon cancer. As one researcher noted, “while the connection between dietary cholesterol and colon cancer is well established, no one has previously explained the mechanism behind it.”

Unlocking the Mechanism: Cholesterol’s Role in Colon Cancer

The study embarked on a transformative journey by utilizing an animal model to dissect the intricate relationship between dietary cholesterol and colon cancer. By subjecting the model to varying levels of dietary cholesterol, the researchers uncovered a remarkable sequence of events. Higher cholesterol intake corresponded to an accumulation of cholesterol within the cell membrane, the outer skin, of colon cells. This accumulation served as a molecular trigger, compelling these cells to undergo accelerated division. With each division, the cells accrued genetic errors at an alarming rate, effectively steering them down the perilous path towards malignancy. Astonishingly, the study revealed that the influence of high dietary cholesterol boosted the formation of tumor cells in the colon by more than a staggering 100-fold.

Elaborating on these findings, the researchers elucidated the process: “as the animals’ cholesterol levels rose, their cells divided more rapidly, causing the tissue lining their guts to expand and their intestines to lengthen. These changes significantly sped up the rate of tumor formation in their colons.” This revelation offered a crucial insight into the interplay between dietary cholesterol, cell division, and the intricate dance of colon cancer development.

A New Paradigm: Dietary Choices and Cancer

The implications of these findings are monumental, painting a vivid picture of the intricate ways in which dietary choices influence the development of colon cancer. As this silent culprit, cholesterol, assumes a prominent role in fuelling cancer progression, it is imperative to reimagine our dietary habits. With colon cancer emerging as a leading cause of mortality, particularly in developed nations, the significance of adopting healthier dietary practices cannot be overstated.

Conclusion: A Call to Action

In the quest to decode the intricate web of factors that drive colon cancer development, researchers have achieved a significant breakthrough by establishing the direct link between dietary cholesterol and malignancy. The study’s revelations underscore the critical importance of adopting dietary habits that minimize cholesterol intake, animal fat consumption, and the consumption of trans-fats and deep-fried foods. The dynamic landscape of nutrition and its impact on human health continues to unveil its secrets, guiding us toward informed choices that hold the potential to transform our well-being.

References

Wang, B., Rong, X., Palladino, E. N. D., Wang, J., Fogelman, A. M., Martín, M. G., … Tontonoz, P. (2018). Phospholipid Remodelling and Cholesterol Availability Regulate Intestinal Stemness and Tumorigenesis. Cell Stem Cell.
https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(17)30519-2

Eat Smart, Live Well, Look Great,

Dr. Meschino

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

Adeeva Supplements
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LMU 58 – Harnessing Calcium Intake to Shield Against Colorectal Cancer: A Comprehensive Approach

Calcium Continues to be Linked to Colon Cancer Prevention

LMU 58 – Harnessing Calcium Intake to Shield Against Colorectal Cancer: A Comprehensive Approach

Source: International Journal of Cancer (2014)

Lifestyle Medicine Update (July 14, 2017)

Introduction:

Colorectal cancer emerges as a formidable adversary, ranking second in cancer-related mortality when considering all genders. However, a ray of hope gleams from studies highlighted in the Journal of the National Cancer Institute. These studies suggest that through prudent dietary and lifestyle practices, a remarkable 70-90% of colon cancer cases can be averted. Among the myriad factors intertwining with colon cancer prevention, optimal calcium intake shines as a beacon. Over the past three decades, scientific exploration has cast calcium in the role of a potential guardian against colorectal cancer. Supported by animal studies and epidemiological investigations, a noteworthy correlation between higher calcium intake and diminished colorectal cancer incidence emerges as a pivotal revelation.

The Calcium-Colorectal Cancer Nexus: An In-Depth Analysis

The potency of calcium in mitigating colorectal cancer risk receives further validation through a compelling 2014 meta-analysis published in the International Journal of Cancer. Drawing insights from 15 distinct human studies, this meta-analysis illuminates a marked reduction in the risk of colorectal cancer associated with elevated calcium intake from both dietary and supplementary sources. Specifically, each incremental 300 mg rise in calcium derived from supplements corresponds to a noteworthy 9% reduction in risk. Equally noteworthy, a parallel 300 mg increase in total calcium intake precipitates an 8% decrease in risk. Remarkably, striving for a daily calcium intake of 1200 mg—recognized as the threshold for optimizing bone density and curbing osteoporosis—aligns with a substantial 32-36% reduction in colon cancer risk. Regrettably, a sizable segment of the population falls short of this target, typically ingesting between 500-800 mg of calcium each day.

Deciphering the Mechanism: How Calcium Engages in Risk Abatement

Peering into the mechanism underlying calcium’s potential to mitigate colon cancer risk unveils its safeguarding attributes. Scientific inquiry reveals that calcium effectively retards the pace of cell division among colon-lining cells. This deceleration curtails the likelihood of genetic anomalies that fuel cancer progression. Furthermore, calcium’s propensity to bind with bile acids in the gut curbs their conversion into secondary sterols, such as lithocholic and deoxycholic acids, recognized instigators of cancer advancement. This two-fold mechanism underscores calcium’s pivotal role in thwarting colorectal cancer.

A Calcium-Rich Regimen: Strengthening Colorectal Well-being

The crux of the matter lies in sustaining a consistent influx of calcium-rich foods into one’s daily diet. Should circumstances necessitate, calcium and vitamin D supplements offer viable alternatives. Notably, vitamin D synergizes with calcium, bolstering not just bone health, but also exerting an influence on reduced colon cancer risk.

Embarking on a Calcium-Enriched Journey: A Plethora of Sources for Colorectal Health

Surveying the diverse landscape of calcium-rich foods unveils a spectrum of options to fortify colon health. From dairy stalwarts like low-fat yogurt and milk to seafood offerings such as sardines and salmon, the array of choices enriches the palate with calcium’s nurturing touch. Similarly, vegetables like collard greens and broccoli, complemented by an eclectic array of fruits, nuts, and legumes, enrich the culinary tapestry with calcium’s protective embrace.

Conclusion: Pioneering Colorectal Health Through Calcium Fortification

The clarion call emanating from the 2014 meta-analysis, supported by decades of meticulous research, urges individuals to recognize calcium’s formidable potential in the realm of colorectal cancer prevention. Empowered by empirical evidence highlighting calcium’s capacity to retard cell division and thwart cancer-inducing transformations, individuals are poised to tread a path fortified by calcium’s protective mantle. By cultivating a diet infused with calcium-rich fare and, where warranted, integrating supplements, individuals can traverse the journey towards colon cancer prevention with the resilience conferred by calcium’s inherent prowess.

References

  1. Keum N, Aune D, Greenwood D.C., Ju W, Giovannucci E.L. Calcium intake and colorectal cancer risk: Dose-response meta-analysis of prospective observational studies. International J Cancer (2014) 135 (8): 1940-1948)

Sources of Calcium-Rich Foods

FoodPortion SizeAmount of Calcium (mg)
Low Fat Yogurt1 cup415
Low Fat Milk (nonfat,1%)I cup300
Low Fat Cottage Cheese½ cup75
Sardines with bones3 oz370
Salmon with bones (canned)3 oz165
Processed Tofu with calcium sulfate4 oz145
Canned Shrimp3 oz100
Cooked Lentils1 cup75
Chicken Breast3 oz10
Tuna3 oz5
Collard Greens½ cup180
Spinach½ cup85
Stalk of Broccoli1 medium70
OrangeI medium55
Green Beans½ cup30
Lettuce½ head15
Orange Juice½ cup10
Apple1 medium10
Whole Wheat Bread1 slice20
Cooked Spaghetti1 cup15
Cooked Rice½ cup10
Apricots, raw, dried4-6 halves24
Dates4-Mar22
Figs Canned335
Figs Dried256
GrapefruitI medium40
Prunes, dried raw527
Raisins¼ cup31
Raspberries2/3 cup40
Strawberries1 cup42
Roasted Almonds1 oz80
Kale½ cup47
Baked Beans½ cup78
White Beans½ cup96
Dry-roasted soybean nuts½ cup232

Introduction

Colorectal cancer emerges as a formidable adversary, ranking second in cancer-related mortality when considering all genders. However, a ray of hope gleams from studies highlighted in the Journal of the National Cancer Institute. These studies suggest that through prudent dietary and lifestyle practices, a remarkable 70-90% of colon cancer cases can be averted. Among the myriad factors intertwining with colon cancer prevention, optimal calcium intake shines as a beacon. Over the past three decades, scientific exploration has cast calcium in the role of a potential guardian against colorectal cancer. Supported by animal studies and epidemiological investigations, a noteworthy correlation between higher calcium intake and diminished colorectal cancer incidence emerges as a pivotal revelation.

The Calcium-Colorectal Cancer Nexus: An In-Depth Analysis

The potency of calcium in mitigating colorectal cancer risk receives further validation through a compelling 2014 meta-analysis published in the International Journal of Cancer. Drawing insights from 15 distinct human studies, this meta-analysis illuminates a marked reduction in the risk of colorectal cancer associated with elevated calcium intake from both dietary and supplementary sources. Specifically, each incremental 300 mg rise in calcium derived from supplements corresponds to a noteworthy 9% reduction in risk. Equally noteworthy, a parallel 300 mg increase in total calcium intake precipitates an 8% decrease in risk. Remarkably, striving for a daily calcium intake of 1200 mg—recognized as the threshold for optimizing bone density and curbing osteoporosis—aligns with a substantial 32-36% reduction in colon cancer risk. Regrettably, a sizable segment of the population falls short of this target, typically ingesting between 500-800 mg of calcium each day.

Deciphering the Mechanism: How Calcium Engages in Risk Abatement

Peering into the mechanism underlying calcium’s potential to mitigate colon cancer risk unveils its safeguarding attributes. Scientific inquiry reveals that calcium effectively retards the pace of cell division among colon-lining cells. This deceleration curtails the likelihood of genetic anomalies that fuel cancer progression. Furthermore, calcium’s propensity to bind with bile acids in the gut curbs their conversion into secondary sterols, such as lithocholic and deoxycholic acids, recognized instigators of cancer advancement. This two-fold mechanism underscores calcium’s pivotal role in thwarting colorectal cancer.

A Calcium-Rich Regimen: Strengthening Colorectal Well-being

The crux of the matter lies in sustaining a consistent influx of calcium-rich foods into one’s daily diet. Should circumstances necessitate, calcium and vitamin D supplements offer viable alternatives. Notably, vitamin D synergizes with calcium, bolstering not just bone health, but also exerting an influence on reduced colon cancer risk.

Embarking on a Calcium-Enriched Journey: A Plethora of Sources for Colorectal Health

Surveying the diverse landscape of calcium-rich foods unveils a spectrum of options to fortify colon health. From dairy stalwarts like low-fat yogurt and milk to seafood offerings such as sardines and salmon, the array of choices enriches the palate with calcium’s nurturing touch. Similarly, vegetables like collard greens and broccoli, complemented by an eclectic array of fruits, nuts, and legumes, enrich the culinary tapestry with calcium’s protective embrace.

Conclusion: Pioneering Colorectal Health Through Calcium Fortification

The clarion call emanating from the 2014 meta-analysis, supported by decades of meticulous research, urges individuals to recognize calcium’s formidable potential in the realm of colorectal cancer prevention. Empowered by empirical evidence highlighting calcium’s capacity to retard cell division and thwart cancer-inducing transformations, individuals are poised to tread a path fortified by calcium’s protective mantle. By cultivating a diet infused with calcium-rich fare and, where warranted, integrating supplements, individuals can traverse the journey towards colon cancer prevention with the resilience conferred by calcium’s inherent prowess.

References

  1. Keum N, Aune D, Greenwood D.C., Ju W, Giovannucci E.L. Calcium intake and colorectal cancer risk: Dose-response meta-analysis of prospective observational studies. International J Cancer (2014) 135 (8): 1940-1948)

Sources of Calcium-Rich Foods

FoodPortion SizeAmount of Calcium (mg)
Low Fat Yogurt1 cup415
Low Fat Milk (nonfat,1%)I cup300
Low Fat Cottage Cheese½ cup75
Sardines with bones3 oz370
Salmon with bones (canned)3 oz165
Processed Tofu with calcium sulfate4 oz145
Canned Shrimp3 oz100
Cooked Lentils1 cup75
Chicken Breast3 oz10
Tuna3 oz5
Collard Greens½ cup180
Spinach½ cup85
Stalk of Broccoli1 medium70
OrangeI medium55
Green Beans½ cup30
Lettuce½ head15
Orange Juice½ cup10
Apple1 medium10
Whole Wheat Bread1 slice20
Cooked Spaghetti1 cup15
Cooked Rice½ cup10
Apricots, raw, dried4-6 halves24
Dates4-Mar22
Figs Canned335
Figs Dried256
GrapefruitI medium40
Prunes, dried raw527
Raisins¼ cup31
Raspberries2/3 cup40
Strawberries1 cup42
Roasted Almonds1 oz80
Kale½ cup47
Baked Beans½ cup78
White Beans½ cup96
Dry-roasted soybean nuts½ cup232
Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

Adeeva Supplements
Posted on by

LMU 49 – The Coffee Conundrum: Caffeine’s Triumph Over Colon Cancer Recurrence

Caffeinated Coffee Strongly Linked to Reduced Colon Cancer

LMU 49 – The Coffee Conundrum: Caffeine's Triumph Over Colon Cancer Recurrence

Source: The Journal of Clinical Oncology 2015

Lifestyle Medicine Update (March 30, 2017)

Introduction

In the realm of innovative medical research, a groundbreaking study published in the Journal of Clinical Oncology in 2015 has unearthed an intriguing correlation between regular caffeinated coffee consumption and a reduced risk of colon cancer recurrence. By delving into the intricate interplay between coffee’s caffeinated compounds and post-treatment colon cancer outcomes, this study offers a new ray of hope for patients seeking to thwart cancer’s return and enhance the likelihood of a complete cure.

Unveiling the Study

The Journal of Clinical Oncology’s 2015 study casts a spotlight on the remarkable potential of caffeinated coffee in safeguarding against colon cancer recurrence. This seminal research involves an exhaustive examination of nearly 1,000 colon cancer patients. Participants in the study underwent a comprehensive evaluation through dietary questionnaires at multiple time points: early in the study, during chemotherapy, and approximately a year later. The study’s remarkable findings highlight those patients who consistently consumed four or more cups of caffeinated coffee per day exhibited the lowest recurrence rate of colon cancer, alongside diminished metastasis and mortality from any cause.

The Power of Caffeine

The study’s pivotal revelation hinges on caffeine’s intrinsic protective properties. With a caffeine intake equivalent to around 460 mg per day, patients who achieved this threshold demonstrated a striking 42 percent reduction in the likelihood of cancer recurrence, compared to their non-coffee-drinking counterparts. Additionally, these avid coffee enthusiasts showcased a 33 percent lower risk of succumbing to cancer or other causes. Intriguingly, the study underscores the gradient effect of coffee consumption on cancer prevention. While two to three cups of coffee per day yielded a more modest benefit, a meager protective effect was observed with a consumption of one cup of coffee or less.

Significance and Implications

The study’s significance is amplified by the temporal window within which colon cancer recurrence typically occurs. Given that most colon cancer recurrences manifest within the initial five years post-treatment, the study’s insights wield substantial relevance. By establishing caffeinated coffee as a potential safeguard against recurrences during this critical period, the study elucidates a practical avenue for patients to fortify their defences.

Furthermore, this study resonates harmoniously with a burgeoning body of research that has extolled the manifold protective virtues of coffee against diverse cancer types. Beyond colon cancer, recent studies have spotlighted coffee’s potential in curbing the development of postmenopausal breast cancer, melanoma, liver cancer, and advanced prostate cancer.

Unlocking Caffeine’s Mechanisms

Scrutinizing the mechanisms through which caffeine exerts its cancer-defying influence unravels a multi-faceted tapestry. Caffeine’s ability to enhance insulin sensitivity emerges as a pivotal player in this narrative. By reducing the body’s insulin requirements post-meals, caffeine precipitates lower insulin levels, which are intrinsically linked to decreased cancer risk and recurrence.

Emerging experimental studies have further delineated caffeine’s prowess. These studies illuminate caffeine’s potential to bolster the efficacy of certain chemotherapy drugs by augmenting their tumor-killing effects. Additionally, caffeine appears to orchestrate the orchestrated demise of nascent cancer cells through programmed cell death, simultaneously quelling cancer cell replication.

Coffee’s Evolution: From Culprit to Cure

The journey of coffee and caffeine within the context of cancer prevention underscores the fluidity of scientific understanding. Once considered potential carcinogens, both coffee and caffeine now experience a paradigm shift from cancer-causing agents to formidable cancer warriors, a transformation catalyzed by a spate of recent cancer studies.

As coffee aficionados ponder the dichotomy of coffee’s perception, it is prudent for those unburdened by caffeine sensitivity to consider integrating two to four cups of coffee per day into their routine. For colon cancer survivors, engaging in a dialogue with their healthcare providers about the potential benefits of consuming four or more cups of caffeinated coffee daily becomes a judicious step. The insights gleaned from the Journal of Clinical Oncology study offer a pivotal bridge between medical research and actionable lifestyle changes.

Conclusion

The Journal of Clinical Oncology’s 2015 study sets a transformative precedent by illuminating the resolute link between caffeinated coffee and reduced colon cancer recurrence risk. As the medical community endeavors to harness the intricate symphony of epigenetic and physiological processes, coffee emerges as a potent conductor that orchestrates an amplified defence against cancer recurrence. By integrating coffee into their daily regimen, individuals might just find an unexpected ally in the formidable battle against cancer’s resurgence.

References

  1. (Main Reference): Brendan J. Guercio, Kaori Sato, Donna Niedzwiecki, Xing Ye, Leonard B. Saltz, Robert J. Mayer, Rex B. Mowat, Renaud Whittom, Alexander Hantel, Al Benson, Daniel Atienza, Michael Messino, Hedy Kindler, Alan Venook, Frank B. Hu, Shuji Ogino, Kana Wu, Walter C. Willett, Edward L. Giovannucci, Jeffrey A. Meyerhardt, and Charles S. Fuchs. Coffee Intake, Recurrence, and Mortality in Stage III Colon Cancer: Results from CALGB 89803 (Alliance). Journal of Clinical Oncology, August 2015
    https://www.sciencedaily.com/releases/2015/08/150817161201.htm
  2. https://www.ncbi.nlm.nih.gov/pubmed/2496063
  3. https://www.ncbi.nlm.nih.gov/pubmed/2496063

Eat Smart, Live Well, Look Great,

Dr. Meschino

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

Adeeva Supplements