Category: Prostate

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LMU 230 – The Prostate Predicament: Can Diet and Lifestyle Make a Difference?

LMU 30

LMU 230 - The Prostate Predicament: Can Diet and Lifestyle Make a Difference?

Source: Food Science Biotechnology Journal (2019)

Lifestyle Medicine Update (February 8, 2022)

Introduction:

Prostate issues are often perceived as an inevitable part of aging, but emerging research reveals dietary and natural approaches to protect and restore prostate health. Saw palmetto, with its DHT-blocking properties, stands out as a promising remedy. Learn how this natural ally, along with a holistic approach and other supplements, can help maintain prostate health.

The Secrets of Prostate Health

Prostate enlargement, a condition affecting nearly all men by the age of 80, is often perceived as an inevitable consequence of aging. However, emerging research suggests that the destiny of one’s prostate may not be entirely sealed by the passage of time. Dietary and lifestyle factors have taken center stage in the quest to fend off prostate enlargement, reverse its effects, and safeguard the prostate from undesirable outcomes.

Understanding the Prostate Enlargement Puzzle

As men age, a pivotal transformation unfolds within their prostate glands. Prostate cells undergo an alteration in which testosterone is converted into dihydrotestosterone (DHT), a hormone responsible for accelerating the division of prostate cells. This increased cell proliferation leads to prostate enlargement, clinically known as Benign Prostatic Hyperplasia (BPH). Unfortunately, an enlarged prostate places pressure on the urethra, causing symptoms such as a weakened urine stream, difficulty initiating urination, and incomplete bladder emptying, often resulting in more frequent trips to the bathroom.

Saw Palmetto: A Natural Guardian

In the realm of natural remedies, Saw palmetto has emerged as a promising ally in the battle against mild to moderate prostate enlargement. In several European countries, Saw palmetto is a common medical treatment for this condition. A 2019 review shed light on three crucial mechanisms through which Saw palmetto demonstrates its ability to prevent and treat BPH:

  1. Blocking DHT Production: Saw palmetto contains fatty acids and sterols that inhibit the enzyme 5-alpha-reductase responsible for the conversion of testosterone into DHT. By impeding DHT accumulation, Saw palmetto helps restrain the rapid division of prostate cells, offering relief to those with mild to moderate BPH.
  2. Inducing Cell Death: Experimental evidence suggests that certain constituents in Saw palmetto can trigger apoptosis, or programmed cell death, in human prostate cancer cells. This finding hints at Saw palmetto’s potential role in preventing the development of prostate cancer.
  3. Anti-Inflammatory Properties: Saw palmetto exhibits anti-inflammatory effects within the prostate gland, adding another layer of defence against prostate enlargement.

A Holistic Approach to Prostate Health

Soy foods, enriched with isoflavones, offer another natural avenue to counteract the conversion of testosterone into DHT in prostate cells. However, taking a supplement that combines standardized Saw palmetto extract with complementary natural agents supporting prostate health proves to be a proactive strategy. This approach combines the prowess of Saw palmetto with nutrients like beta-sitosterol, Pygeum africanum, soy extract, and stinging nettle, creating a formidable arsenal against prostate woes.

A Prescription for Prostate Health

For men aged 40 and above, proactively managing DHT concentrations in the prostate is advisable. Regular consumption of soy foods and a supplement featuring the Saw palmetto combination is a prudent choice. This preventive measure gains added significance as some of these natural agents exhibit promising anti-cancer effects in prostate research studies.

In the interest of prostate health, it’s essential for men to prioritize prevention, especially those over 40. The promising research surrounding these natural allies underscores the importance of staying informed and proactive.

Reference:

Kwon Y. Use of saw palmetto (Serena repens) extract for benign prostatic hyperplasia. Food Sci Biotechnol. 2019; 28(6): 1599-1606 [Link](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859144/)

 

Eat Smart, Live Well, Look Great,

Dr. Meschino

Introduction:

Prostate issues are often perceived as an inevitable part of aging, but emerging research reveals dietary and natural approaches to protect and restore prostate health. Saw palmetto, with its DHT-blocking properties, stands out as a promising remedy. Learn how this natural ally, along with a holistic approach and other supplements, can help maintain prostate health.

 

The Secrets of Prostate Health

Prostate enlargement, a condition affecting nearly all men by the age of 80, is often perceived as an inevitable consequence of aging. However, emerging research suggests that the destiny of one’s prostate may not be entirely sealed by the passage of time. Dietary and lifestyle factors have taken center stage in the quest to fend off prostate enlargement, reverse its effects, and safeguard the prostate from undesirable outcomes.

Understanding the Prostate Enlargement Puzzle

As men age, a pivotal transformation unfolds within their prostate glands. Prostate cells undergo an alteration in which testosterone is converted into dihydrotestosterone (DHT), a hormone responsible for accelerating the division of prostate cells. This increased cell proliferation leads to prostate enlargement, clinically known as Benign Prostatic Hyperplasia (BPH). Unfortunately, an enlarged prostate places pressure on the urethra, causing symptoms such as a weakened urine stream, difficulty initiating urination, and incomplete bladder emptying, often resulting in more frequent trips to the bathroom.

Saw Palmetto: A Natural Guardian

In the realm of natural remedies, Saw palmetto has emerged as a promising ally in the battle against mild to moderate prostate enlargement. In several European countries, Saw palmetto is a common medical treatment for this condition. A 2019 review shed light on three crucial mechanisms through which Saw palmetto demonstrates its ability to prevent and treat BPH:

  1. Blocking DHT Production: Saw palmetto contains fatty acids and sterols that inhibit the enzyme 5-alpha-reductase responsible for the conversion of testosterone into DHT. By impeding DHT accumulation, Saw palmetto helps restrain the rapid division of prostate cells, offering relief to those with mild to moderate BPH.
  2. Inducing Cell Death: Experimental evidence suggests that certain constituents in Saw palmetto can trigger apoptosis, or programmed cell death, in human prostate cancer cells. This finding hints at Saw palmetto’s potential role in preventing the development of prostate cancer.
  3. Anti-Inflammatory Properties: Saw palmetto exhibits anti-inflammatory effects within the prostate gland, adding another layer of defence against prostate enlargement.

A Holistic Approach to Prostate Health

Soy foods, enriched with isoflavones, offer another natural avenue to counteract the conversion of testosterone into DHT in prostate cells. However, taking a supplement that combines standardized Saw palmetto extract with complementary natural agents supporting prostate health proves to be a proactive strategy. This approach combines the prowess of Saw palmetto with nutrients like beta-sitosterol, Pygeum africanum, soy extract, and stinging nettle, creating a formidable arsenal against prostate woes.

A Prescription for Prostate Health

For men aged 40 and above, proactively managing DHT concentrations in the prostate is advisable. Regular consumption of soy foods and a supplement featuring the Saw palmetto combination is a prudent choice. This preventive measure gains added significance as some of these natural agents exhibit promising anti-cancer effects in prostate research studies.

In the interest of prostate health, it’s essential for men to prioritize prevention, especially those over 40. The promising research surrounding these natural allies underscores the importance of staying informed and proactive.

Reference:

Kwon Y. Use of saw palmetto (*Serena repens*) extract for benign prostatic hyperplasia. *Food Sci Biotechnol*. 2019; 28(6): 1599-1606 [Link](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859144/)

 

Eat Smart, Live Well, Look Great,

Dr. Meschino

Prostate 40 Plus

Scientific evidence suggests that men need targeted nutrient support to preserve optimal prostate health after age 40. Read More…..

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU – 189 The Mediterranean Diet’s Remarkable Impact on Prostate Cancer

LMU-189

LMU – 189 The Mediterranean Diet's Remarkable Impact on Prostate Cancer

Source: Journal “Cancer” (2021)

Lifestyle Medicine Update (January 30, 2021)

Introduction:

In January 2021, a groundbreaking study published in the journal “Cancer” illuminated the profound influence of the Mediterranean diet on the progression of localized, low-grade prostate cancer in men. The findings provided compelling evidence that adopting a Mediterranean-style diet significantly reduces the risk of disease progression, ultimately mitigating the need for invasive treatments such as prostate removal surgery or radiation therapy.

The study tracked 410 men diagnosed with low-grade localized prostate cancer, specifically with Gleason scores of 1 and 2. These individuals were placed on a watchful waiting protocol, allowing specialists to monitor the pace at which their cancer might advance. Throughout the study, participants underwent regular testing of their prostate-specific antigen (PSA) and testosterone levels.

The trial’s demographics revealed a diverse group, with 82.9% of participants being Caucasian, 8.1% Black, and 9% belonging to other or unknown ethnicities. The median age of the subjects was 64, with 15% having diabetes, and 44% utilizing statin drugs for managing high cholesterol. Each participant’s customary dietary habits were assessed, and they were assigned a Mediterranean diet score based on their typical daily and weekly eating patterns.

The results of the study were nothing short of remarkable. Men who closely adhered to the Mediterranean diet exhibited a substantially lower risk of prostate cancer progression. In fact, for every one-point increase in their Mediterranean diet score, researchers observed a remarkable reduction of over 10% in the risk of disease progression over the course of the three-year study.

The Mediterranean Diet: A Prescription for Prostate Health

Digging deeper into the study’s findings, it becomes evident that men who embraced a diet rich in fruits, vegetables, legumes, cereals, and fish experienced a reduced likelihood of their prostate cancer advancing to a critical stage necessitating aggressive treatment options like radical prostatectomy or radiation therapy. These treatments can significantly impact one’s quality of life, making the Mediterranean diet an appealing alternative.

Even among participants with diabetes using metformin and those with high cholesterol relying on statin drugs, adherence to these dietary principles translated into a reduced risk of prostate cancer progression. The study’s conclusion underscores the significance of the Mediterranean diet: “A Mediterranean diet is non-invasive, promotes overall health, and, as demonstrated by this study, holds the potential to influence cancer progression positively.”

The Nutrient-Rich Nexus

These findings echo those of Dr. Dean Ornish MD, who previously demonstrated that a vegan diet designed to combat heart disease also yielded improved outcomes for patients with localized prostate cancer of low to moderate grade. Dr. Ornish’s patients supplemented their diets with vitamins E and C, selenium, and other key nutrients. What these findings emphasize is the presence of an array of nutrients in fruits, vegetables, and legumes that exhibit the capacity to inhibit the development and progression of prostate cancer. Several studies have even shown that natural agents from these foods, such as soy isoflavones, lycopene, ground flaxseed, green tea catechins, and vitamin D, can effectively restrain prostate cancer in clinical trials when employed during the watchful waiting stage or as part of a holistic medical management approach.

Prevention Through Diet: The Promising Route

The Adventist Health Study-2 offers additional insights into the preventative potential of dietary choices. It revealed that vegan men experienced a 33% reduced risk of developing prostate cancer, underscoring the role of a plant-based diet in mitigating the risk. Other research studies published in the International Journal of Cancer suggest that prudent dietary practices can reduce the risk of up to 75% of prostate cancer cases. The mounting evidence suggests that adopting a diet rich in plant-based foods containing various phytonutrients with anti-prostate cancer properties should be a top consideration for all men. Prostate cancer stands as the second leading cause of cancer-related death in this region, with significant potential for prevention through dietary and lifestyle improvements.

Conclusion:

In conclusion, the study published in “Cancer” in January 2021 underscores the formidable impact of the Mediterranean diet on mitigating the progression of localized, low-grade prostate cancer. It offers hope for those diagnosed with the condition, providing a non-invasive, health-promoting alternative to more aggressive treatments. Additionally, the findings reinforce the value of a diet rich in fruits, vegetables, legumes, and key nutrients as an essential tool in the fight against prostate cancer. As we strive to reduce the prevalence of this disease, it is increasingly clear that prudent dietary and lifestyle choices play a pivotal role in safeguarding prostate health.

References:

January 2021 Study:

  1. Justin R. Gregg et al. Adherence to the Mediterranean diet and grade group progression in localized prostate cancer: An active surveillance cohort. Cancer, January 2021                                                                                                                                                                                          [Read more](https://acsjournals.onlinelibrary.wiley.com/doi/10.1002/cncr.33182)
  2. Supplements Used in Complementary Management of Prostate Cancer Studies: National Cancer Institute: Prostate Cancer, Nutrition, and Dietary Supplements (PDQ) – Patient Version                                                                                                                                                                                  [Learn more](https://www.cancer.gov/about-cancer/treatment/cam/patient/prostate-supplements-pdq)
  3.  Dr. Dean Ornish MD Study of Localized Prostate Cancer with Low-to-Moderate Gleason Score:                                                                                 [Read the study](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1518978/pdf/envhper00368-0167.pdf)
  4.  Adventist Health Study-2 (Vegans and Prostate Cancer):                                                                                                                                                           [Learn more](https://www.adventistreview.org/church-news/story3607-vegan-diet-cuts-risk-of-prostate-cancer-adventist-study-finds)
  5. Prevention of Prostate Cancer by 75%: Willett W. Diet, nutrition, and avoidable cancer. Environmental Health Perspectives. 1995,103(Suppl 8):165-170                                                                                                                                                                                                                         [Read more](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1518978/pdf/envhper00368-0167.pdf)
Eat Smart, Live Well, Look Great,
 

Dr. Meschino

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 32 – Alcohol and Prostate Cancer: A Dose-Dependent Connection

"Alcohol and Prostate Cancer "

LMU 32 – Alcohol and Prostate Cancer: A Dose-Dependent Connection

Source: Journal – Biomedical Sciences – Cancer Research, November, 2016

Lifestyle Medicine Update (December 1, 2016)

Introduction:

In the intricate realm of cancer research, a pivotal study appeared in November 2016, gracing the pages of the esteemed journal “Biomedical Sciences – Cancer Research.” This study embarked on a meticulous journey, harnessing the power of a meta-analysis to explore the intricate relationship between alcohol consumption and prostate cancer. For years, the scientific community had been tantalized by studies like the Harvard Alumni Study, which hinted at the correlation between alcohol consumption and heightened prostate cancer risk. However, the lack of conclusive evidence compelled experts to tread cautiously, withholding definitive statements until a robust body of evidence appeared.

Unearthing a Dose-Dependent Trend: Alcohol and Prostate Cancer Risk

The veil of uncertainty finally lifted with the groundbreaking meta-analysis presented in the November 2016 issue. This comprehensive review, encompassing 27 available studies, casts a spotlight on alcohol’s role in prostate cancer risk. The findings illuminate a dose-dependent pattern, where the magnitude of risk escalates with the volume of alcohol consumed. In essence, the more one indulges in alcohol, the graver the threat of prostate cancer becomes.

The study’s outcomes unveiled a compelling narrative:

  • Low-volume drinkers (up to two drinks per day) faced an 8% elevated risk of prostate cancer.
  • Medium-volume drinkers (up to four drinks per day) encountered a 7% higher risk.
  • High-volume drinkers (up to six drinks per day) confronted a 14% augmented risk.

  • Those venturing into the realm of higher-volume drinking (six drinks or more per day) were plagued with an 18% intensified risk.

A Paradigm Shift: Recognizing Alcohol’s Role in Prostate Cancer

The repercussions of this study have resonated deeply within the realm of healthcare expertise. Health professionals are contemplating the inclusion of prostate cancer alongside other malignancies wherein alcohol serves as a confirmed risk factor, a list encompassing breast cancer, liver cancer, colon cancer, and esophageal cancer. The mechanisms underpinning alcohol’s ability to fuel prostate cancer development are multifaceted, encompassing the generation of free radicals, estrogen escalation, and the disruption of folic acid metabolism—a pivotal process in synthesizing and stabilizing our genes. Although forthcoming investigations need to illuminate the intricate dynamics between alcohol and prostate cancer, and the intricate mechanisms steering the course of prostate cancer development, a sage approach beckons men to confine their alcohol intake to a mere 3-5 drinks per week, or even consider abstaining altogether.

Shaping Cancer Prevention: A Prudent Path

In an era when cancer looms as a formidable adversary, especially prostate cancer—ranked as the second leading cause of cancer-related deaths among men—a clarion call for proactive measures emerges. A compelling body of evidence underscores the potential to stave off up to 75% of prostate cancer cases through judicious dietary and lifestyle choices. The clarion call becomes resounding when evidence spotlights alcohol as a pivotal factor that can tip the scales in the battle against prostate cancer. Amidst the intricate tapestry of cancer prevention, a prudent stance emerges—limiting alcohol consumption, embodying a potent armor in the quest to mitigate prostate cancer risk.

References:

  1. https://bmccancer.biomedcentral.com/articles/10.1186/s12885-016-2891-z
  2. http://www.medscape.com/viewarticle/872085
Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 23 – Pomegranate Juice: The Exceptional Choice for Cancer Prevention

Influence of Pomegranate Juice on Prostate

LMU 23 – Pomegranate Juice: The Exceptional Choice for Cancer Prevention

Source: International Journal of Molecular Sciences (2014)

Lifestyle Medicine Update (Sept 3, 2016)

Introduction

The consumption of fruit juices, especially those high in simple carbohydrates, has been a matter of concern due to their potential to spike blood sugar levels and contribute to weight gain. However, one juice stands out as an exception to this rule – pure pomegranate juice. Emerging research has shown that pomegranate juice has unique properties that may help slow or even reverse the progression of prostate cancer, the second leading cause of cancer death. Additionally, preclinical studies suggest that pomegranate juice may also offer protection against breast cancer and other types of cancer.

The Remarkable Anti-Cancer Effects of Pomegranate Juice

Several studies have highlighted the beneficial effects of pomegranate juice on cancer prevention and treatment. Pomegranate juice has shown to suppress the growth of human prostate cancer cells and induce apoptosis, or programmed cell death, in these cells. Furthermore, it decreases the synthesis of certain hormones and prostaglandins known to promote the proliferation and metastasis of prostate cancer cells. Pomegranate juice has also been shown to inhibit matrix metalloproteineases, which allow cancer cells to invade adjacent tissues.

Ellagic acid, a component of pomegranate juice, has shown anti-cancer effects on other types of cancer, including lung, cervical, and breast cancer. The evidence from experimental studies supports the notion that pomegranate juice can be a valuable part of a cancer prevention strategy.

Clinical Trials on Pomegranate Juice and Prostate Cancer

Two human clinical trials, using 8 ounces of pomegranate juice daily, were conducted on men with advanced prostate cancer that was unresponsive to conventional medical treatment. Both trials showed remarkable results, with a dramatic slowing of the PSA doubling time and programmed cell death induced in prostate cancer cells. Another study in 2014 used a supplement containing extracts from pomegranate, green tea, broccoli, and curcumin on men with existing prostate cancer. The results showed a significant inhibition of prostate cancer progression in the group taking the supplement compared to the placebo group.

Potential Therapeutic Use Against Other Cancers

Pomegranate constituents have shown effectiveness against various cancers, including breast, lung, colon, and skin cancer. The shared molecular mechanisms between different cancer types further enhance the therapeutic potential of pomegranate extract.

Conclusion: The Exceptional Juice for Cancer Prevention

While many fruit juices are often praised for their health benefits, pomegranate juice stands out as a scientifically supported choice for cancer prevention. Its unique anti-cancer effects, especially in prostate cancer, have been proven in both experimental and clinical studies. Therefore, it is recommended to consume 4 ounces of pure pomegranate juice daily as part of a cancer prevention strategy.

References:

Wang L, Martins-Green M. Pomegranate juice and its constituents as alternative treatment for prostate cancer. Int J Molecular Sciences. 2014;15(8):14949-149666. (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC420076)

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 15 – Green Tea Catechins: A Promising Strategy for Preventing and Managing Prostate Cancer

LMU-15

LMU 15 – Green Tea Catechins: A Promising Strategy for Preventing and Managing Prostate Cancer

Source: Journal Cancer Research, 2006, and Journal Cancer Prevention and Research, 2009

Lifestyle Medicine Update (July 16, 2016)

Introduction:

Green tea has gained widespread recognition for its numerous health benefits, and recent scientific investigations have highlighted the potential role of green tea catechins (GTCs) in the prevention and management of prostate cancer. Groundbreaking studies have revealed that GTCs can stabilize and even reverse precancerous prostate lesions, known as high-grade intra-epithelial neoplasia (HGPIN), which often precede the development of prostate cancer.

Study 1: Preventing Prostate Cancer Progression

In 2006, a significant study published in the Journal of Cancer Research focused on 60 men diagnosed with HGPIN. These men were followed for a year, with half receiving a daily supplement of GTCs containing 600 mg (three capsules of 200 mg each), while the other half receiving a placebo. The results were remarkable, as only 3% of the men in the GTCs-treated group developed tumors, compared to a significantly higher incidence of 30% among the placebo group. Moreover, the GTCs-treated group exhibited consistently lower levels of prostate-specific antigen (PSA) and improvements in symptoms related to benign prostatic hyperplasia and lower urinary tract issues.

Study 2: Impact on Established Prostate Cancer

In 2009, a follow-up study published in the Journal of Cancer Prevention Research looked at the effects of GTCs in men with localized prostate cancer who were awaiting surgical treatment (radical prostatectomy). Twenty-six men with positive prostate biopsies were given a daily supplement containing 800 mg of GTCs until the day of surgery. The results showed a decrease in various prostate cancer biomarkers, including PSA, hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF), insulin-like growth factor (IGF-I), and its binding proteins (IGFBP-3).

Mechanism of Action

The proposed mechanism of action for GTCs in prostate cancer involves inhibiting the HGF/c-Met signalling pathway, which plays a crucial role in cancer progression and metastasis. C-Met receptors are often over-expressed in prostate tumors, and high levels of HGF are associated with metastatic disease and reduced survival rates. GTCs have demonstrated the ability to block the production of HGF and VEGF in prostate cancer-associated fibroblast cell lines, providing further evidence of their potential in managing prostate cancer.

The Promise of Green Tea Catechins as Adjuvant Therapy

Based on these compelling findings, green tea catechins show great promise as adjuvant therapy in men with prostate cancer. The data suggest that GTCs may contribute to lowering cytokine levels, such as HGF and VEGF, which are known to drive prostate cancer progression. For those interested in supporting prostate health, consuming 3-5 cups of green tea daily or supplementing with green tea catechins (approximately 200-600 mg daily) could benefit their routine.

Conclusion: Embracing Green Tea Catechins for Prostate Health

The research on green tea catechins and their impact on prostate health continues to provide encouraging results. Incorporating green tea into daily habits or considering GTCs supplementation could be a valuable step toward maintaining prostate health and reducing the risk of prostate cancer.

References:

  1. Bettuzzi S., Brausi M., Rizzi F., et al. Chemoprevention of Human Prostate Cancer by Oral Administration of Green Tea Catechins in Volunteers with High-Grade Prostate Intraepithelial Neoplasia: A Preliminary Report from a One-Year Proof-of-Principle Study. Cancer Res., January 15, 2006, 66; 123.
  2. McLarty J., Bigelow R., Smith M., et al. Tea Polyphenols Decrease Serum Levels of Prostate-Specific Antigen, Hepatocyte Growth Factor, and Vascular Endothelial Growth Factor in Prostate Cancer Patients and Inhibit the Production of Hepatocyte Growth Factor and Vascular Endothelial Growth Factor In vitro. Cancer Prev. Res. July 2009, 2; 673.
Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU – 01 The Protective Effect of Vegetarianism Against Prostate Cancer

LMU-01

LMU 01 - The Protective Effect of Vegetarianism Against Prostate Cancer

Source: American Journal of Clinical Nutrition (January, 2016)

Nutrition / Natural Medicine Update (February , 2016)

Introduction:

Prostate cancer remains a significant health concern for men worldwide, accounting for 27% of all male cancers and the second most common cancer among men (excluding skin cancers). In January 2016, the American Journal of Clinical Nutrition published a groundbreaking study that explored the association between vegetarianism and prostate cancer risk. This large-scale study, conducted on over 26,000 men as part of the Adventists Health Study-2, revealed compelling evidence suggesting that a vegan diet could confer considerable protection against prostate cancer. This article aims to delve into the study’s key findings, the potential mechanisms behind this protective effect, and the phytonutrients found in plant-based foods that may be crucial in inhibiting prostate cancer development.

The Study’s Key Findings:

The research conducted by Tantamango-Bartley et al. involved a comprehensive analysis of a large cohort of men, with 1079 cases of prostate cancer identified during the study period. Of particular interest were the findings related to vegan men, who exhibited an impressive 35% lower risk of developing prostate cancer than their non-vegan counterparts. This observation suggests a protective association between vegan diets and prostate cancer risk. The study also noted that this protective effect was particularly pronounced among white male vegans, with a similar, albeit slightly weaker, trend observed in black male vegans.

Mechanisms Behind the Protective Effect:

The reduced risk of prostate cancer observed among vegan men can be attributed, at least in part, to the presence of various phytonutrients abundant in plant-based foods. These bioactive compounds have been shown to possess potent anti-cancer properties, particularly for prostate cancer. Some of the critical mechanisms include:

  1. Cruciferous Vegetables: Cruciferous vegetables, such as broccoli, Brussels sprouts, cabbage, cauliflower, bok choy, and turnips, contain indole-3 carbinol and sulforaphane. These compounds have demonstrated powerful anti-cancer effects, including inhibiting prostate cancer cell growth and the induction of cancer cell death.
  2. Cooked Tomatoes: Tomatoes are a rich source of lycopene, a carotenoid pigment with potent antioxidant properties. Numerous studies have linked lycopene consumption to a reduced risk of prostate cancer.
  3. Soy Products: Soybeans and soy-based products are abundant in isoflavones and protease inhibitors, which have shown promise in preventing prostate cancer or improving outcomes in prostate cancer patients.
  4. Legumes: Peas and beans are excellent sources of lignans and protease inhibitors, compounds that may play a role in reducing prostate cancer risk.
  5. Green Tea: Green tea contains catechins, a type of polyphenol with potent antioxidant and anti-cancer properties. Studies suggest that regular green tea consumption may lower the risk of developing prostate cancer.
  6. Pomegranate Juice: Pomegranate juice is rich in ellagic acid, a compound with potential anti-cancer effects, inhibiting prostate cancer cell growth.
  7. Ground Flaxseed: Flaxseed is a source of enterolactone and enterodiol, associated with preventing pre-cancerous prostate cells from progressing into full-blown cancer.

Supporting Studies:

The findings from this study align with a growing body of evidence from various research endeavors. Numerous studies have independently validated the protective effects of these plant-based nutrients against prostate cancer. Consistent consumption of foods rich in these compounds has been associated with a lower risk of prostate cancer in diverse populations. Furthermore, scientists have synthesized some of these beneficial nutrients into supplements, showing promising results as adjunctive interventions for prostate cancer patients or preventive measures.

Conclusion

The study’s results published in the American Journal of Clinical Nutrition present compelling evidence supporting the association between vegan diets and a lower risk of prostate cancer. Although not everyone may adopt a strict vegan lifestyle, incorporating more plant-based foods with proven anti-cancer properties represents a prudent approach to reducing the risk of prostate cancer.

Additionally, it is essential to recognize that many of the same plant-based foods and phytonutrients shown to lower prostate cancer risk have also demonstrated protective effects against breast cancer in various studies. Therefore, these dietary recommendations may extend to women as well.

As with any health-related advice, individuals should consult with their healthcare providers before significantly changing their diets or lifestyles.

Reference

Tantamango-Bartley Y, Knutsen SF et al. Are strict vegetarians protected against prostate cancer? American Journal of Clinical Nutrition, vol 103, issue 1. 2016. (Link: http://ajcn.nutrition.org/content/103/1/153.abstract).


Eat Smart, Live Well, Look Great!

Dr. James Meschino

Introduction:

Prostate cancer remains a significant health concern for men worldwide, accounting for 27% of all male cancers and the second most common cancer among men (excluding skin cancers). In January 2016, the American Journal of Clinical Nutrition published a groundbreaking study that explored the association between vegetarianism and prostate cancer risk. This large-scale study, conducted on over 26,000 men as part of the Adventists Health Study-2, revealed compelling evidence suggesting that a vegan diet could confer considerable protection against prostate cancer. This article aims to delve into the study’s key findings, the potential mechanisms behind this protective effect, and the phytonutrients found in plant-based foods that may be crucial in inhibiting prostate cancer development.

The Study’s Key Findings:

The research conducted by Tantamango-Bartley et al. involved a comprehensive analysis of a large cohort of men, with 1079 cases of prostate cancer identified during the study period. Of particular interest were the findings related to vegan men, who exhibited an impressive 35% lower risk of developing prostate cancer than their non-vegan counterparts. This observation suggests a protective association between vegan diets and prostate cancer risk. The study also noted that this protective effect was particularly pronounced among white male vegans, with a similar, albeit slightly weaker, trend observed in black male vegans.

Mechanisms Behind the Protective Effect:

The reduced risk of prostate cancer observed among vegan men can be attributed, at least in part, to the presence of various phytonutrients abundant in plant-based foods. These bioactive compounds have been shown to possess potent anti-cancer properties, particularly for prostate cancer. Some of the critical mechanisms include:

  1. Cruciferous Vegetables:  Cruciferous vegetables, such as broccoli, Brussels sprouts, cabbage, cauliflower, bok choy, and turnips, contain indole-3 carbinol and sulforaphane. These compounds have demonstrated powerful anti-cancer effects, including inhibiting prostate cancer cell growth and the induction of cancer cell death.
  2. Cooked Tomatoes: Tomatoes are a rich source of lycopene, a carotenoid pigment with potent antioxidant properties. Numerous studies have linked lycopene consumption to a reduced risk of prostate cancer.
  3. Soy Products:  Soybeans and soy-based products are abundant in isoflavones and protease inhibitors, which have shown promise in preventing prostate cancer or improving outcomes in prostate cancer patients.
  4. Legumes: Peas and beans are excellent sources of lignans and protease inhibitors, compounds that may play a role in reducing prostate cancer risk.
  5. Green Tea: Green tea contains catechins, a type of polyphenol with potent antioxidant and anti-cancer properties. Studies suggest that regular green tea consumption may lower the risk of developing prostate cancer.
  6. Pomegranate Juice: Pomegranate juice is rich in ellagic acid, a compound with potential anti-cancer effects, inhibiting prostate cancer cell growth.
  7. Ground Flaxseed: Flaxseed is a source of enterolactone and enterodiol, associated with preventing pre-cancerous prostate cells from progressing into full-blown cancer.

Supporting Studies:

The findings from this study align with a growing body of evidence from various research endeavors. Numerous studies have independently validated the protective effects of these plant-based nutrients against prostate cancer. Consistent consumption of foods rich in these compounds has been associated with a lower risk of prostate cancer in diverse populations. Furthermore, scientists have synthesized some of these beneficial nutrients into supplements, showing promising results as adjunctive interventions for prostate cancer patients or preventive measures.

Conclusion

The study’s results published in the American Journal of Clinical Nutrition present compelling evidence supporting the association between vegan diets and a lower risk of prostate cancer. Although not everyone may adopt a strict vegan lifestyle, incorporating more plant-based foods with proven anti-cancer properties represents a prudent approach to reducing the risk of prostate cancer.

Additionally, it is essential to recognize that many of the same plant-based foods and phytonutrients shown to lower prostate cancer risk have also demonstrated protective effects against breast cancer in various studies. Therefore, these dietary recommendations may extend to women as well.

As with any health-related advice, individuals should consult with their healthcare providers before significantly changing their diets or lifestyles.

Reference

Tantamango-Bartley Y, Knutsen SF et al. Are strict vegetarians protected against prostate cancer? American Journal of Clinical Nutrition, vol 103, issue 1. 2016. (Link: http://ajcn.nutrition.org/content/103/1/153.abstract).

Eat Smart, Live Well, Look Great!

Dr. James Meschino

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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