Category: Kidney Disease

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LMU 287 – Glutathione Helps Guard Against Age-Related Decline in Kidney Function

LMU-287

Nurturing Kidney Health: Vital Strategies for Aging Well

Source: American Journal of Tanslational Research (2021)

Lifestyle Medicine Update (May 11, 2023)

Understanding Age-Related Kidney Decline

As we age, our kidneys naturally experience a decline in function, becoming one of the fastest aging organs. This decline typically commences around age 30-40 and accelerates into our 50s and 60s. Alarmingly, over 50% of individuals aged over 75 undergo a significant decline in kidney function, often unnoticed. This deterioration, known as mild insufficiency or chronic kidney disease, significantly heightens the risk of heart attacks.

The Significance of Kidney Health

Kidney disease claims more lives annually than breast and prostate cancer combined. Advanced kidney disease may necessitate dialysis or even a kidney transplant, emphasizing the critical importance of preserving kidney function for prolonged well-being.

Identifying Kidney Risk Factors

Numerous factors contribute to kidney disease, including high blood pressure, diabetes, kidney stones, family history, prolonged use of pain medications, and age over 60. Certain autoimmune conditions also elevate the risk of kidney damage and declining function.

Combatting Kidney Decline with Antioxidants

Research suggests that free radical damage to kidney cells significantly contributes to age-related kidney function decline and is associated with conditions such as diabetes and autoimmune disorders. Studies indicate that higher free radical levels correlate with accelerated kidney function decline as we age.

Harnessing Supplements for Kidney Protection

Thankfully, targeted dietary supplements can aid in preventing or reversing kidney function decline. Research has shown that supplements like N-acetylcysteine (NAC) can boost glutathione synthesis in kidney cells, improving kidney function and reducing inflammation. Additionally, supplements such as alpha-lipoic acid, silymarin (from Milk thistle), L-glutamine, Coenzyme Q10, and choline (found in lecithin capsules) elevate kidney glutathione levels, providing additional protection against kidney damage.

Recommended Supplement Regimen

Consider supplementing with a combination containing:

  • NAC (N-acetylcysteine)
  • Alpha-lipoic acid
  • L-Glutamine
  • Milk thistle (standardized to 80% silymarin content)

Incorporating CoQ10 and lecithin capsules into your regimen can further bolster kidney health.

Taking Proactive Steps for Kidney Health

Individuals over 40-50 should consider supplementing to support kidney function. Consult with your healthcare provider, especially if you have existing kidney disease. Regular kidney function screening through blood tests is essential. Share the provided references with your healthcare professional to facilitate informed discussions about incorporating these supplements into your health regimen.

Thanks for watching and I’ll see you next time.

References:

National Kidney Foundation: Decline in Kidney Function with Aging and Incidence of Kidney Disease
https://www.kidney.org/news/monthly/wkd_aging#:~:text=Kidney%20disease%20can%20develop%20at,believed%20to%20have%20kidney%20disease.

Aging and Kidney Function
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2744545/

Decreased Glutathione in Aging:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8457589/

NAC Supplementation and Kidney Function
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8129408/

Silymarin in Diabetic Nephropathy
https://pubmed.ncbi.nlm.nih.gov/25340091/

Alpha Lipoic Acid in Renal Damage – Ferroptosis
https://www.frontiersin.org/articles/10.3389/fphys.2021.680544/full

Alpha Lipoic Acid in Diabetic Nephropathy
https://pubmed.ncbi.nlm.nih.gov/23531536/

L-Glutamine Raises Glutathione Levels
https://biomedres.us/pdfs/BJSTR.MS.ID.002293.pdf

CoQ10 Supplementation in Kidney Disease
https://pubmed.ncbi.nlm.nih.gov/35643375/#:~:text=Oral%20Coenzyme%20Q10%20supplementation%20leads,to%20primary%20Coenzyme%20Q10%20deficiency

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587473/

Betaine in Kidney and Liver Function:
https://karger.com/cpb/article/32/Suppl.%201/32/71803/Betaine-Transport-in-Kidney-and-Liver-Use-of

Betaine in Kidney Function (osmoprotectant)
https://karger.com/cpb/article/32/Suppl.%201/32/71803/Betaine-Transport-in-Kidney-and-Liver-Use-of

 

Eat Smart, Live Well, Look Great,

Dr. Meschino

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Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 255 – Kidney Stones: A Dietary Solution for Prevention and Recurrence

LMU-255

Kidney Stones: A Dietary Solution for Prevention and Recurrence

Source: Mayo Clinic Proceedings (August 1, 2022)

Lifestyle Medicine Update (August 24, 2022)

Introduction:

Kidney stones are infamous for their excruciating pain, affecting around 12% of the global population, according to a 2018 report in Advances in Urology. What’s even more alarming is that 30% of those who have experienced a kidney stone are at risk of a painful recurrence. However, recent research has uncovered a dietary approach that could be the key to preventing these agonizing stones from forming again.

The Kidney Stone Conundrum

Kidney stones can be attributed to a variety of factors, with calcium oxalate stones being the most prevalent type. Historically, it was widely believed that excessive calcium intake, including calcium supplements, was a culprit in kidney stone formation. But new insights from a 2022 review by Mayo Clinic researchers have reshaped our understanding of how to prevent these painful stones and their recurrence.

The Power of Calcium and Potassium

The study, which examined questionnaires from kidney stone patients over nearly a decade, delivered a surprising revelation: a low intake of calcium and potassium significantly elevates the risk of recurrent stone formation. Contrary to past beliefs, it appears that insufficient calcium intake, not excessive, is linked to kidney stone development. In fact, the researchers recommend a daily intake of 1200 mg of calcium to prevent kidney stones, a quantity that also happens to be beneficial in reducing the risk of osteoporosis. The best source for this essential mineral is healthy foods like non-fat or 1% yogurt, although dietary supplements may be necessary to meet this target.

Sourcing Adequate Potassium

The researchers did not pinpoint a specific potassium requirement, but health authorities typically recommend a daily intake of 3500-4700 mg. Fortunately, a wide array of potassium-rich fruits and vegetables, including bananas, oranges, grapefruits, apricots, mushrooms, peas, cucumbers, zucchini, and melons like cantaloupe and honeydew, can help you meet this goal. Additionally, fruits and vegetables contain other nutrients that further reduce the risk of kidney stones, as indicated by the Mayo Clinic research team.

Hydration and Caffeine: A Formidable Duo

Maintaining proper hydration is also crucial. The study revealed that fluid intake below 3,400 ml per day, roughly equivalent to nine 12 oz glasses of fluids, is associated with first-time kidney stone formation. Interestingly, caffeine intake plays a role in prevention by acting as a diuretic, diluting minerals in the urine, and reducing their propensity to bond with oxalic acid, a major component in stone formation.

Conclusion: A Recipe for Kidney Stone Prevention

Kidney stones are undoubtedly a painful and concerning condition. The findings from this recent research underscore the importance of calcium intake, a diverse selection of fruits and vegetables to acquire potassium, maintaining adequate hydration, and even indulging in caffeine-rich beverages like coffee and tea to keep these troublesome stones at bay. With these dietary strategies, you can protect yourself from kidney stone development and the agonizing recurrences.

References:

  1. Alelign T and Petros B. “Kidney stone disease: An update on current concepts.” Adv Urol. 2018.
  2. “Diets higher in calcium and potassium may help prevent recurrent symptomatic kidney stones.” Science Daily, August 1, 2022.
  3. John Lieske, MD, director, O’Brien Urology Research Center, Mayo Clinic, Rochester, Minn.; Gary Curhan, MD, professor, Harvard Medical School; Mayo Clinic Proceedings, Aug. 1, 2022.
 
Eat Smart, Live Well, Look Great,
 

Dr. Meschino

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU – 178 Unlocking the Brain’s Memory Vault: Choline’s Role in Cognitive Health

LMU-178

LMU – 178 Unlocking the Brain's Memory Vault: Choline's Role in Cognitive Health

Main Sources: Journal Nutrients (2019) and the American Journal of Clinical Nutrition (2011)

Lifestyle Medicine Update (October 24, 2020)

Introduction:

In the mysterious realm of our minds, memory reigns supreme. At the heart of this cognitive wonderland lies a remarkable chemical known as acetylcholine, the guardian of our memories. But, to craft this vital molecule, our brain cells need a steady supply of a humble nutrient called choline. Surprisingly, choline remains a stranger to many, concealed within the folds of various foods. Yet, for most individuals, daily choline intake falls short of the recommendations set by health authorities. Today, we embark on a journey to uncover the profound impact of choline on our cognitive well-being and the secrets it holds in the realm of memory.

Choline and Cognitive Health: A Crucial Bond

In the intricate tapestry of cognitive health, choline emerges as a central figure. Research has persistently unveiled the pivotal role of choline in safeguarding memory and cognitive function. The contours of this narrative come to life through the renowned Framingham Heart Study, where over 1,400 participants embarked on a voyage of dietary analysis, neuropsychological assessments, and brain MRI studies. At an average age of 61, these individuals ventured into uncharted territory, revealing astonishing findings. Those who consistently included substantial choline in their diets emerged as champions of memory, boasting superior test scores and fewer MRI signs of cognitive decline.

The White Matter Connection: Choline’s Neurological Shield

In the intricate landscape of our brains, white matter hyperintensity (WMH) serves as an ominous harbinger of cognitive decline and brain atrophy. Here, the protective influence of choline reveals its potency. High choline intake correlates with reduced WMH, shielding the brain from degeneration. This effect is attributed to choline’s dual role – not only does it bolster memory by increasing acetylcholine levels, but it also fortifies the outer skin of brain cells, preserving their integrity and functionality. As a result, choline stands as a formidable guardian, fending off brain cell degeneration and mortality.

The Intricate Dance: Choline and Saturated Fat

However, this tale of choline’s heroics carries a caveat. In those who indulge in excessive saturated fat consumption, choline’s protective mantle falters. The deleterious impact of saturated fats neutralizes choline’s memory-enhancing powers and its ability to safeguard the brain on MRI scans. The message is clear – while choline is a beacon of cognitive well-being, it thrives in synergy with prudent dietary choices. Opt for choline-rich foods, while simultaneously moderating saturated fat intake. This dietary harmony is a key to preserving memory and cognitive health.

Choline’s Multifaceted Defence

Choline’s role transcends memory preservation. It also emerges as a sentinel against elevated homocysteine levels, a known risk factor for Alzheimer’s disease. Choline contributes to homocysteine reduction, partially through its conversion to betaine in the liver. In the annals of animal studies, choline showcases its prowess by curbing the menacing accumulation of amyloid plaque, an ominous hallmark of Alzheimer’s disease. Furthermore, it quells brain inflammation, often seen in this condition, by taming inflammation-promoting brain cells known as microglia. Thus, choline emerges as a guardian of memory and brain health, wielding a multifaceted defence against cognitive decline.

Choline’s Daily Quota: How Much is Enough?

The voyage to memory preservation through choline requires a calculated course. Health authorities recommend a daily choline intake of 550 mg for men, 425 mg for women, and elevated levels for pregnant and breastfeeding women. However, the stark reality reveals a different narrative. On average, men ingest only about 380 mg of choline daily, while women hover around 275 mg. This shortfall accumulates over time, culminating in sub-optimal choline levels within the brain. The consequence? An increased risk of dementia and Alzheimer’s disease.

Nutritional Allies: Choline-Rich Foods

To traverse the path of memory preservation, one must be well-acquainted with the allies of choline-rich foods. These nutritional champions stand as beacons of cognitive well-being:

  • Tofu: A 150 gm serving packs 160 mg of Choline.
  • Chicken Breast: A 75 gm serving delivers 80 mg of Choline.
  • Fish (most varieties): A 3 oz serving contains 71 mg of Choline.
  • Soybeans: A ¾ cup serving provides 60 mg of Choline.
  • Other Beans and Peas: A ¾ cup serving boasts 57 mg of Choline.
  • Lentils: A ¾ cup serving offers 45 mg of Choline.
  • Nuts (peanuts, pistachios, almonds, cashews): A ¼ cup serving contributes 23 mg of Choline.
  • Non-fat or 1% Milk: A 1 cup serving supplies 43 mg of Choline.
  • Cottage Cheese: A 1 cup serving yields 42 mg of Choline.
  • Non-fat or 1% Yogurt: A ¾ cup serving provides 27 mg of Choline.
  • Broccoli, Brussel Sprouts, Cauliflower, Collard Greens: A ½ cup serving contains 35 mg of Choline.
  • Avocado: Half an avocado delivers 14 mg of Choline.
  • Banana: A medium banana contributes 12 mg of Choline.
  • Potato: A large potato contains 57 mg of Choline.
  • Brown Rice: A cup of cooked brown rice provides 19 mg of Choline.
  • Whole Grain Bread and Pita: A large piece offers 17 mg of Choline.
  • Tangerines and Kiwi Fruit: Half a cup of each provides 7-10 mg of Choline.
  • Carrots: A ½ cup serving boasts 6 mg of Choline.
  • Wheat Germ: A 30 gm serving, approximately 1 oz, delivers 54 mg of Choline.
  • Quinoa: A ½ cup serving supplies 23 mg of Choline.

Lecithin: A Convenient Choline Source

Navigating the labyrinth of choline-rich foods may seem challenging. To simplify this journey, some choose to embrace lecithin supplements. Each 1200 mg capsule of lecithin contains approximately 160 mg of choline, making it a convenient way to bolster choline intake. Moreover, lecithin boasts other phospholipids that contribute to brain, liver, and kidney health, as well as the overall well-being of most body cells. However, it’s worth noting that lecithin in granule form, despite containing a substantial 250 mg of choline per tablespoon, may deter many due to its pungent fishy odour and taste.

Conclusion: Cultivating Cognitive Vigilance

In the grand tapestry of cognitive health, choline assumes the role of a silent hero. Its contributions extend beyond memory preservation to shield the brain from Alzheimer’s disease and cognitive decline. However, achieving the recommended choline intake presents a formidable challenge, as many fall short through diet alone. To safeguard our cognitive legacy, let us embark on a journey of culinary exploration, embracing choline-rich foods. And for those seeking a streamlined path, lecithin supplements offer a convenient solution. In this quest to preserve memory and cognitive function, choline emerges as a vital ally, inviting us to explore the boundless potential of our minds.

References:

  1. Poly C et al. The relation of dietary choline to cognitive performance and white-matter hyperintensity in the Framingham offspring cohort. Am J Clin Nutr. 2011; 94(6):1584-1591                                                                                                                                                                                    [Read more](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252552)
  2. Bekdash RA. Neuroprotective effects of choline and other methyl donors. Nutrients. 2019; 11, 2995.                                                                    [Read more](https://www.mdpi.com/2072-6643/11/12/2995)
  3. Velazquez R et al. Lifelong choline supplementation ameliorates Alzheimer’s disease pathology and associated cognitive deficits by attenuating microglia activation. Aging Cell, 2019.                                                                                                                                                                          [Read more](https://onlinelibrary.wiley.com/doi/full/10.1111/acel.13037)
 
Eat Smart, Live Well, Look Great
 

Dr. Meschino

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 84 – Guarding Your Vital Organs: Navigating Acetaminophen with Wisdom

LMU-84

LMU 84 – Guarding Your Vital Organs: Navigating Acetaminophen with Wisdom

Source: Journal Drug Development Research (2015)

Lifestyle Medicine Update (March 24, 2018)

Introduction

In the labyrinth of pain relief and fever reduction, acetaminophen stands as a familiar warrior, offering solace through its widespread presence in over-the-counter medications. A household name, epitomized by Tylenol, this pharmaceutical soldier has witnessed an astonishing 27 billion doses dispensed in 2009 alone. With its unparalleled efficacy, however, comes an ominous downside—acetaminophen’s potential to ravage the liver and, to some extent, the kidneys. Positioned as the leading culprit behind drug-induced liver failure in our world, acetaminophen warrants attention and understanding. It’s time to delve into this intricate narrative, exploring the mechanisms that render this painkiller a double-edged sword, capable of both healing and harm.

The Stealthy Culprit: Acetaminophen’s Wrath on the Liver

Acetaminophen has garnered notoriety for inducing liver failure, a consequence that stems from its transformation within the liver. Metabolized into a fierce and reactive agent known as the NAPQI metabolite, acetaminophen emerges as a formidable adversary to liver cells. This metabolite inflicts damage and even death upon these cells, culminating in the tragic cascade of liver failure. The twist in this tale lies in the role of glutathione, a vital protector that can counteract and neutralize the NAPQI metabolite, rendering it harmless and paving the way for its elimination from the body.

The Depleting Defender: Acetaminophen’s Impact on Glutathione

However, a cruel irony unfolds with the chronic use of acetaminophen. This seemingly benevolent ally stealthily depletes glutathione levels not just in the liver, but throughout the body, orchestrating a gradual deterioration of liver cells. The consequence is twofold: liver cell damage and eventual cell death. The intricate dance between acetaminophen, its metabolite, and the body’s defence mechanism is a critical juncture to understand in the quest to protect our precious organs.

A Lifesaving Ally: NAC Steps onto the Stage

Amidst the tumultuous backdrop of acetaminophen’s impact, an unsung hero emerges in the form of N-Acetylcysteine (NAC). This natural substance holds the key to mitigating the impending damage caused by acetaminophen overdose. In cases of acute overdose, hospitals administer NAC as a potent antidote. NAC serves as a building block for the synthesis of glutathione, rapidly restoring its levels and halting liver failure in its tracks. This medical marvel has paved the way for a potential safeguard against liver damage induced by regular acetaminophen usage.

NAC: Beyond Acute Overdose

Recent studies have unveiled a promising prospect—the oral ingestion of NAC, available as a supplement, as a defence against chronic acetaminophen usage. A notable study published in the journal Drug Development Research in 2015 shed light on this matter. This research postulates that acetaminophen-containing drugs should ideally be paired with an equal dose of NAC to avert liver damage with each dose of acetaminophen ingested. Although this recommendation has yet to be heeded by lawmakers and pharmaceutical companies, its potential to shape the future of pain relief strategies is undeniable.

Elevating Glutathione: A Symphony of Natural Allies

While NAC takes center stage, other natural allies can also join the fight to preserve and elevate glutathione levels:

  • Alpha-lipoic acid (ALA): A powerful antioxidant that complements NAC in raising and maintaining glutathione levels.
  • Silymarin (Milk Thistle): Not only supporting liver repair but also safeguarding kidney cells from the clutches of diverse free radicals induced by various drugs and toxins.
  • L-Glutamine: A pivotal amino acid vital for glutathione synthesis.
  • Combination Supplements: Some companies have harnessed the synergy of NAC, ALA, Silymarin, and L-Glutamine into a single supplement.

Nutrition: A Fundamental Defender

Beyond supplements, the realm of nutrition also wields the power to fortify liver function and bolster detoxification. Incorporating certain foods can support your body’s innate ability to thrive:

  • Garlic: A natural ally in the pursuit of liver health.
  • Onions: Partnering with garlic in promoting overall well-being.
  • Cruciferous Vegetables: A host of superheroes, such as broccoli, Brussels sprouts, cabbage, cauliflower, and Bok choy, offer indole 3 carbinol and sulforaphane, compounds that amplify detoxification.

A Lesson in Moderation: Beware the Alcohol Trap

While navigating the realm of acetaminophen, another crucial factor beckons for attention—alcohol. Combining alcohol with acetaminophen amplifies the liver and kidney damage potential of this drug. A cardinal rule emerges: abstain from alcohol while under the influence of acetaminophen to shield your vital organs from this potent combination.

Conclusion: Empower Yourself with Knowledge

In the tapestry of our lives, acetaminophen’s role emerges as both a healer and a harvester of damage. Armed with the understanding of its potential pitfalls and protective allies, you can take charge of your well-being. While lawmakers and pharmaceutical giants ponder the integration of NAC with acetaminophen, you can proactively safeguard your liver and kidneys. By embracing NAC supplements, harnessing the power of natural agents, and incorporating liver-friendly foods, you embark on a journey of empowerment. In the pursuit of wellness, knowledge is your greatest armor.

References

  1. Owumi S, Andrus JP, et al. Co-administration of N-Acetylcysteine and Acetaminophen Efficiently Blocks Acetaminophen Toxicity. Drug Dev Res 76 : 251-258, 2015. © 2015 Wiley Periodicals, Inc. [Link to study](https://onlinelibrary.wiley.com/doi/full/10.1002/ddr.21262#references-section)
  2. Deaths from Acetaminophen: [ProPublica Article](https://www.propublica.org/article/tylenol-mcneil-fda-behind-the-numbers)
  3. Sears S.E. Chelation: Harnessing and Enhancing Heavy Metal Detoxification – A Review. Scientific World Journal. 2013. [Link to study](https://www.hindawi.com/journals/tswj/2013/219840) : Children’s Hospital of Eastern Ontario Research Institute

Eat Smart, Live Well, Look Great

Dr. Meschino

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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