Category: Dementia

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LMU 267 – The Potential and Perils of Metformin: A Double-Edged Sword in the Fight Against Disease

LMU-267

The Potential and Perils of Metformin: A Double-Edged Sword in the Fight Against Disease

Source: 13th International Conference on Alzheimer’s and Parkinson’s disease (Abstract 312), presented on March 29, 2017, and reviewed in the December 5, 2022, Medscape Article

Lifestyle Medicine Update (December 6, 2022)

Introduction:

Metformin, a staple in diabetes management, has garnered attention for its potential in cancer prevention and heart health. However, concerns have arisen regarding its link to neurological disorders like Parkinson’s disease and dementia. While studies show its efficacy in impeding cancer progression, recent research indicates its role in impairing mitochondria, raising concerns. Natural alternatives such as soy isoflavones, EGCG, curcumin, and lifestyle choices offer protective benefits without these risks. Embracing holistic approaches and lifestyle medicine is a promising path to well-being.

The Diabetes Wonder Drug with Unforeseen Consequences

Metformin, a household name in diabetes management, has earned its reputation as the go-to drug for type 2 diabetes. Beyond its blood sugar-lowering capabilities, it boasts a unique set of skills that makes it a contender in the realm of cancer prevention and heart health. For diabetics, it’s more than just a glucose regulator; it’s a potential shield against cancer development and cardiovascular disease. This wonder drug has sparked conversations about its broader use in the general population, especially after the age of 50. But beneath its impressive façade lies an unexpected twist, one that has raised concerns about its potential link to neurological disorders like Parkinson’s disease and dementia.

The Metformin Marvel: A Guardian Against Disease

Metformin’s efficacy extends far beyond glycemic control. It has emerged as a formidable opponent in the battle against several health challenges. Notably, it has shown prowess in impeding the progression of cancer, making it a beacon of hope for diabetics. Studies suggest that diabetics prescribed Metformin exhibit cancer rates nearly 30% lower than their counterparts who opt for other glucose-lowering medications. With cancer and heart disease dominating the leading causes of death, it’s not surprising that many physicians have advocated for Metformin use beyond diabetes management, heralding it as a preventive shield.

A Dubious Connection: Metformin and the Dark Side of Mitochondria

But, as with most medical marvels, there is often more than meets the eye. Over the past decade, studies have unearthed an unsettling revelation – Metformin’s role in undermining the energy-producing powerhouses of our cells, mitochondria. More specifically, it interferes with Complex I in the mitochondria, a crucial cog in the cellular energy generation machinery. The impairment of Complex I in mitochondria is a significant player in the development of Parkinson’s disease, a prevalent movement disorder affecting one in 600 people over 60. This impairment is intricately linked to exposure to certain pesticides, namely rotenone and paraquat, which inhibit Complex I in the mitochondria and significantly elevate the risk of Parkinson’s disease. Animal studies further validate this association, demonstrating that Complex I inhibitors can incite Parkinson’s disease-like symptoms in these creatures.

The grim revelation that Metformin follows in the footsteps of these pesticides led to a landmark study presented at the 13th International Conference on Alzheimer’s and Parkinson’s disease. The results, published in an eye-opening Medscape article titled “Metformin Use Linked to Increased Dementia, Parkinson’s Risk in Patients with Diabetes,” found that in a cohort of 9300 type 2 diabetes patients in Taiwan, the risk of developing Parkinson’s disease and dementia was more than doubled in those treated with Metformin compared to those treated with alternative glucose-lowering drugs. Even after accounting for all other risk factors, including those for dementia and Parkinson’s, the results remained unequivocal. “The cumulative incidences of Parkinson’s and dementia were significantly higher in our Metformin cohort at 12 years,” emphasized Dr. Kuan, one of the lead researchers behind the study. Moreover, the study disclosed a worrisome trend: higher dosages and extended Metformin use correlated with an even greater risk of Parkinson’s disease and dementia, particularly after 300 days of continuous use and doses exceeding 240 grams (2400 mg) per day.

The Dilemma: To Metformin or Not to Metformin?

This research carries significant weight, especially as some experts propose Metformin as a universal shield against cancer and heart disease. However, the newfound risk of dementia and Parkinson’s disease casts a long shadow of doubt over this once-venerated drug. To complicate matters further, Metformin’s suppression of the immune system, known for increasing the susceptibility to infections, adds to the equation. Hence, it becomes vital to explore alternatives that can offer similar protective effects against cancer and cardiovascular disease without the looming risks of Parkinson’s and dementia. And the good news is that such alternatives do exist.

Nature’s Armor: Natural Compounds for Disease Prevention

Soy isoflavones found in soy products and soy extract supplements, EGCG from green tea and green tea extract supplements, and curcumin, a polyphenol found in the spice turmeric and curcumin-containing supplements, have been identified as potential contenders in the battle against cancer and heart disease. They act as natural inhibitors, much like Metformin, but without the ominous shadow of neurodegenerative disorders. Aerobic exercise and caloric restriction, including intermittent fasting, offer additional strategies to thwart the mTOR pathway, which is closely tied to the risk of cancer and cardiovascular disease. These holistic approaches encompass a wide array of tools to safeguard health and longevity without the unsettling side effects associated with Metformin.

The Power of Natural Nutrition and Lifestyle Medicine

The journey towards well-being need not rely solely on pharmaceutical interventions. Nutrition and lifestyle medicine have proven time and again to be potent allies in the battle against various diseases. As the population ages and the debate over Metformin’s extended usage continues, it is crucial to remember that a treasure trove of options exists. This new approach to wellness should be embraced more broadly, ultimately finding its place in our conventional healthcare system. For those who seek to reduce their risk of cancer and heart disease without courting the shadow of Parkinson’s or dementia, the power of natural compounds, exercise, and dietary strategies holds the promise of a brighter and healthier future.

References:

  1. [Environmental Health Perspectives – Rotenone and Paraquat Linked to Parkinson’s Disease](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114841/)
  2. [Frontiers in Endocrinology – Metformin-Induced Mitochondrial Complex I Inhibition](https://www.frontiersin.org/articles/10.3389/fendo.2018.00753/full)
  3. [Medscape – Metformin Use Linked to Increased Dementia, Parkinson’s Risk in Patients with Diabetes](https://www.medscape.com/viewarticle/877965#vp_2)
  4. [Harvard Health Publishing – Is Metformin a Wonder Drug](https://www.health.harvard.edu/blog/is-metformin-a-wonder-drug-202109222605#:~:text=For%20decades%20we’ve%20known,with%20diabetes%20lose%20excess%20weight.)
  5. [Cancer Management and Research – The Beneficial Effects of Metformin on Cancer Prevention and Therapy](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497052/)
  6. [Anticancer Agents in Medicinal Chemistry – Updates of mTOR Inhibitors](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2980558/#:~:text=Besides%2C%20some%20natural%20products%2C%20such,to%20inhibit%20mTOR%20as%20well)
  7. [International Journal of Molecular Sciences – The Role of Curcumin in Modulation of Ageing](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273643/)
  8. [Oxidative Medicine and Cellular Longevity – New Insights into the Role of Exercise in Inhibiting mTOR Signaling](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186337/)
  9. [Cell Cycle – Calorie Restriction: Decelerating mTOR-Driven Aging from Cells to Organisms (including Humans)](https://www.tandfonline.com/doi/pdf/10.4161/cc.9.4.10766)
 
 

Eat Smart, Live Well, Look Great,

Dr. Meschino

These impressive findings have prompted some doctors to suggest that we all should take Metformin after the age of 50 to help reduce the risk of cancer and cardiovascular disease, the two leading causes of death in our society. However, evidence published within the past decade has also shown that Metformin inhibits the function of the cell’s energy factory, known as the mitochondria. More specifically, it inhibits the function of Complex I in the mitochondria, which is vitally important for cells to make the energy they require for normal functioning. Studies show that impairment of Complex I in the mitochondria is an important step in the development of Parkinson’s disease, which is the leading movement disorder, affecting one in 600 people over the age of 60. Exposure to pesticides, rotenone, and paraquat, which inhibit Complex I in the mitochondria is strongly linked to an increased risk of Parkinson’s disease. Animal studies have confirmed that Complex I inhibitors, including rotenone and paraquat, cause the development of Parkinson’s disease-like symptoms in animals.

Because Metformin also inhibits Complex I in the cell’s mitochondria, it was postulated by some researchers that, like certain pesticides, it may also increase the risk of Parkinson’s disease.  These suspicions were realized in the research results presented at the 13th International Conference on Alzheimer’s and Parkinson’s disease (Abstract 312), presented on March 29, 2017, and discussed in a Medscape article published on December 5, 2022, entitled, “Metformin Use Linked to Increased Dementia, Parkinson’s Risk in Patients with Diabetes”.

In this study, researchers followed 9300 patients with type 2 diabetes in Taiwan for up to 12 years and found that the risk for Parkinson’s disease and dementia was more than double in the diabetics treated with Metformin, compared to the diabetic patients who were treated with other glucose-lowering drugs during the same period. The results remained unchanged after controlling for all other risk factors for dementia and Parkinson’s disease. As they stated, “The cumulative incidences of Parkinson’s and dementia were significantly higher in our Metformin cohort at 12 years” (Dr. Kuan). The study also showed that the higher the dosage and the longer the duration of Metformin use, the greater the risk of Parkinson’s disease and dementia, especially after 300 days of continuous use and doses higher than 240 grams (2400 mg) per day.

I believe these findings are very important because as the population ages some doctors are suggesting that we use Metformin to help prevent cancer and cardiovascular disease, even if we don’t have type 2 diabetes. But this study is suggesting that it may have the negative effect of increasing the risk for dementia and Parkinson’s disease. Furthermore, Metformin also depresses the immune system, which is associated with an increased risk for infections. So, it should interest you to know that some natural compounds work in a similar way as Metformin to reduce the risk of cancer and cardiovascular disease without increasing the risk of Parkinson’s disease and dementia or weakening the immune system. Some of these natural compounds include:

  • Soy isoflavones (found in soy products and soy extract supplements)
  • EGCG (found in green tea and green tea extract supplements)
  • Curcumin (found in the spice turmeric and curcumin-containing supplements)

Also included on this list of cancer and cardiovascular protecting strategies is Aerobic exercise and caloric restriction (including intermittent fasting), which also inhibit the mTOR pathway linked to cancer and cardiovascular disease risk.

I’ve been tempted over the years to use the drug Metformin as an intervention to further reduce cancer and cardiovascular disease risk, but the evidence pointing to an increased risk of dementia and Parkinson’s disease from use of this drug has convinced me to continue to exclusively use only the more natural nutrition, exercise, and supplementation strategies I have employed thus far. In fact, some of these natural supplements and food constituents, as well as exercise and caloric restriction, are shown to also help to prevent Parkinson’s disease and dementia as well. Nutrition and lifestyle medicine is good medicine, and it needs to be featured more in our overall conventional healthcare system.

I have included the references for all this information in the text below.

References:

Spivey A. Rotenone and paraquat linked to Parkinson’s disease: Human exposure study supports years of animal studies. Environ Health Perspect. 2011; 119 (6): A259 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114841/

Sherer TB et al. Mechanism of toxicity in rotenone models of Parkinson’s disease. J Neursci. 2002; 23 (34): 10756-10764. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6740985/

 Metformin use linked to increased dementia, Parkinson’s disease risk in patients with diabetes. Medscape. Monday December 5, 2022. https://www.medscape.com/viewarticle/877965#vp_2

Fontaine E. Metformin-induced mitochondrial complex I inhibition: Facts, uncertainties, and consequences. Frontiers in Endocrinology (Dec 17, 2018) https://www.frontiersin.org/articles/10.3389/fendo.2018.00753/full

Is Metformin a Wonder Drug Harvard Health Publishing (September 29, 2021). https://www.health.harvard.edu/blog/is-metformin-a-wonder-drug-202109222605#:~:text=For%20decades%20we’ve%20known,with%20diabetes%20lose%20excess%20weight.

Saraei P et al. The beneficial effects of metformin on cancer prevention and therapy: A comprehensive review of recent advances. Cancer Manag Res. 2019; 11: 3295-3313. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497052/

Natural Agents that Reduce Cancer and Cardiovascular Disease via mTOR pathway Inhibition similar to Metformin Cancer Prevention Effect:

Zhou H et al. Updates of mTOR inhibitors. Anticancer Agents Med Chem. 2010; Sept 1: 10 (7): 571-581 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2980558/#:~:text=Besides%2C%20some%20natural%20products%2C%20such,to%20inhibit%20mTOR%20as%20well

Huang C et al. Soy isoflavones regulate lipid metabolism through AKT/mTOR1 pathway in diet-induced obesity (DIO) male rats. J Molecules. 2016 May; 21 (5): 586 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273643/

Bielak-Zmijewska et al. The role of curcumin in modulation of ageing. Int J Mol Sci. 2019; 29 (5): 1239 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273643/

Agostini D et al. New insights into the role of exercise in inhibiting mTOR signaling in triple-negative breast cancer. Oxid Med Cell Longev. 2018: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186337/

Blagosklonny MV. Calorie restriction: Decelerating mTOR-driven aging from cells to organisms (including humans). Cell Cycle. 2009https://www.tandfonline.com/doi/pdf/10.4161/cc.9.4.10766

 

Eat Smart, Live Well, Look Great,

Dr. Meschino

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Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 262 – Defying Dementia: The Powerful Link Between Blood Pressure and Cognitive Health

LMU-262

Defying Dementia: The Powerful Link Between Blood Pressure and Cognitive Health

Source: Neuroscience News (October 2022)

Lifestyle Medicine Update (October 26, 2022)

Introduction:

The road to preserving our cognitive vitality is an enticing journey, and science has unveiled a crucial milestone along this path. High blood pressure, a known precursor to heart attacks and strokes, has been thrust into the spotlight as a potential guardian against dementia. A groundbreaking study conducted in 2022 unearthed a stunning revelation: Lowering high blood pressure in individuals aged 69 and older could significantly reduce the risk of dementia. This revelation ignites hope for millions worldwide, and the journey begins by exploring the fascinating discoveries made by researchers delving into the intricate connection between blood pressure and cognitive health.

The Grand Study: Unveiling the Link

Within the realm of medical research, the magnitude of this revelation is matched only by the scale of the study. Over 28,000 individuals from 20 countries, with an average age of 69 and a history of high blood pressure, ventured into a comprehensive examination. The scientists dissected data from five double-blind placebo-controlled randomized trials and meticulously followed the participants until the onset of dementia. Averaging just over four years of follow-up, the study unveiled a profound truth. As one of the researchers enthused, “We found there was a significant effect of treatment in lowering the odds of dementia associated with a sustained reduction in blood pressure in this older population.” Furthermore, they proclaimed, “Our results imply a broadly linear relationship between blood pressure reduction and lower risk of dementia, regardless of which type of treatment was used.” In essence, the extent of blood pressure reduction directly correlates with a diminished risk of dementia, irrespective of the method employed, whether it’s pharmaceutical intervention, exercise, weight loss, or dietary supplementation.

The Myths Shattered: All Means Lead to the Same End

In the past, tantalizing possibilities hinted at the superiority of certain blood pressure-lowering drugs known as ARBs (angiotensin receptor-blockers) in reducing dementia and Alzheimer’s risk. However, the monumental review in 2022 shatters these myths. It demonstrates that simply lowering high blood pressure, by any available means, is a formidable shield against dementia as the years roll by. Apart from pharmaceutical treatments, a treasure trove of natural approaches stands as potent allies in the battle against high blood pressure. Shedding excess body fat, engaging in regular aerobic exercise, curtailing salt intake, increasing daily calcium intake, harnessing the power of Coenzyme Q10 and Hawthorn supplements, incorporating omega-3 fats, and embracing meditation and progressive relaxation techniques are among the powerful methods at our disposal.

The Looming Dementia Epidemic

Dementia, a menacing spectre, has been growing relentlessly on a global scale, currently afflicting approximately 50 million individuals worldwide. Alarming projections indicate that this figure is set to triple by 2050, primarily fuelled by aging populations. The financial toll of dementia is staggering, with healthcare costs estimated at US$20,000-$40,000 per individual annually in the United States. In light of these harrowing statistics, monitoring your blood pressure becomes a paramount responsibility. If it climbs to concerning heights, a silver lining emerges in the form of drugs that can offer a lifeline. Nevertheless, the message is clear – lifestyle medicine, a complementary approach to conventional treatment, should not be overlooked. The amalgamation of diet, exercise, weight loss, supplementation, and mind-body techniques can either reduce the need for high blood pressure medications or lower their required dosage, thus minimizing potential adverse side effects.

Conclusion

The quest to safeguard our cognitive faculties has taken a significant stride. The revelation that lowering high blood pressure is intrinsically linked to a reduced risk of dementia is a beacon of hope for millions at risk of cognitive decline. In the journey to a healthier heart and mind, both pharmaceutical and natural interventions offer a formidable alliance. This revelation, founded on a colossal 2022 study, propels us forward in the battle against dementia.

Reference

  1. “Best evidence yet that lowering blood pressure can prevent dementia.” *Neuroscience News*, October 25, 2022. [Read more here](https://neurosciencenews.com/blood-pressure-dementia-21721/).

Eat Smart, Live Well, Look Great,
 

Dr. Meschino

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 140 – Unveiling the Power of Choline: Nourishing Memory and Cognitive Vitality

LMU-140

LMU 140 – Unveiling the Power of Choline: Nourishing Memory and Cognitive Vitality

Source: American Journal of Clinical Nutrition (July 2019)

Lifestyle Medicine Update (August 22, 2019)

Introduction:

Step into the realm of cognitive health, where the elements of choline and phosphatidylcholine weave a tale of memory, cognition, and vitality. Our journey takes us through the pages of science, unravelling the delicate connection between brain chemistry and the foods we consume.

Choline: The Architect of Memory

Intriguingly, the brain crafts a memory elixir known as “acetylcholine” from the building blocks of choline and phosphatidylcholine. These components, nestled within a range of foods, hold the power to shape memory and cognitive function. A fascinating revelation surfaces—when choline levels in the brain decline, so does acetylcholine, ushering in a decline in memory capabilities.

A Glimpse into Research: Choline and Cognitive Health

A monumental study, housed within the archives of the “American Journal of Clinical Nutrition” in 2019, paints a vivid portrait of choline’s impact on cognitive health. This scholarly endeavor unearthed a groundbreaking insight—a link between dietary phosphatidylcholine intake and the risk of dementia as we traverse the journey of aging. Moreover, the study unveiled an enchanting connection—a higher phosphatidylcholine intake correlated with enhanced cognitive performance.

The Finnish Men and Their Journey: Unravelling the Tale

The study’s narrative commences with approximately 2,500 Finnish men, aged 42 to 60. These subjects opened the door to their dietary habits, lifestyles, and health journeys. The canvas broadened—hospital records, causes of death, medication reimbursement records—all intricately woven into a tapestry of data, spanning 22 years.

Cognition Under the Microscope: Insights Unveiled

Four years into the study’s initiation, nearly 500 men undertook tests designed to measure memory and cognitive processing. The journey’s plot deepened—337 men encountered dementia. A revelation emerged—the risk of dementia stood 28% lower in those who embraced a diet rich in phosphatidylcholine. As the curtains unveiled their story, men with elevated phosphatidylcholine intake showcased not just a shield against dementia but also mastery over memory and linguistic prowess.

The Key to Cognitive Well-being: Choline in Focus

Choline emerged as the star of this cognitive saga. A treasure trove of memory preservation and cognitive vigor, it weathered meticulous scrutiny. The study’s canvas encompassed a spectrum of factors, ranging from lifestyle to nutrition—a thorough examination of dementia’s risk factors. Even the enigmatic APOE4 gene, a sentinel of Alzheimer’s predisposition, found its place in the narrative, revealing no significant sway over the findings. The researchers’ verdict resounded—higher phosphatidylcholine intake offered a fortress against dementia, ushering in a symphony of cognitive brilliance in Eastern Finnish men.

The Choline Quandary: A Glance at the American Reality

Across the ocean, the American tale unfolds, casting a spotlight on choline consumption. Startling facts emerge—most adults fall short of the recommended choline intake, prescribed by the US Food and Nutrition Board. The decree stands—550 mg daily for men and 425 mg for women. The canvas offers a portrait—average daily choline intake in adults spans 402 mg in men and 278 mg in women.

Charting the Course to Cognitive Health: Foods Rich in Choli

A chart surfaces, adorned with the bounty of choline found in common, healthful foods. Beef, egg yolk, and beef liver beckon from the high choline ranks, yet caution flags arise due to their links with health issues. A symphony of alternatives emerges—soybeans, chicken breast, Atlantic cod, shiitake mushrooms, and more—each harboring respectable choline content.

A Personal Approach: Nourishing Cognitive Wellness

On a personal note, the journey veers towards a daily ritual—an intake of 1-2 lecithin capsules, each harboring 1200 mg of lecithin. In this elixir of wellness, phosphatidylcholine thrives, nurturing the cognitive garden.

Epilogue: Nurturing Cognitive Brilliance

As the narrative reaches its culmination, the tapestry of choline’s impact emerges in vivid hues. A testament to memory, cognition, and the quest for a vibrant mind, this tale is etched with the threads of scientific exploration. Yet, wisdom’s voice reverberates—consult the guide, the physician, for personalized steps towards cognitive well-being.

References:

Main Reference

Maija P T Ylilauri, Sari Voutilainen, Eija Lönnroos, Heli E K Virtanen, Tomi-Pekka Tuomainen, Jukka T Salonen, Jyrki K Virtanen. Associations of dietary choline intake with risk of incident dementia and with cognitive performance: the Kuopio Ischaemic Heart Disease Risk Factor Study. The American Journal of Clinical Nutrition, 2019, https://academic.oup.com/ajcn/advance-article-abstract/doi/10.1093/ajcn/nqz148/5540729?redirectedFrom=fulltext
Choline Requirements and Average Intake: National Institutes of Health – Office of Dietary Supplements https://ods.od.nih.gov/factsheets/Choline-HealthProfessional/

 

Eat Smart, Live Well, Look Great,

Dr. Meschino

Introduction:

Step into the realm of cognitive health, where the elements of choline and phosphatidylcholine weave a tale of memory, cognition, and vitality. Our journey takes us through the pages of science, unravelling the delicate connection between brain chemistry and the foods we consume.

Choline: The Architect of Memory

Intriguingly, the brain crafts a memory elixir known as “acetylcholine” from the building blocks of choline and phosphatidylcholine. These components, nestled within a range of foods, hold the power to shape memory and cognitive function. A fascinating revelation surfaces—when choline levels in the brain decline, so does acetylcholine, ushering in a decline in memory capabilities.

A Glimpse into Research: Choline and Cognitive Health

A monumental study, housed within the archives of the “American Journal of Clinical Nutrition” in 2019, paints a vivid portrait of choline’s impact on cognitive health. This scholarly endeavor unearthed a groundbreaking insight—a link between dietary phosphatidylcholine intake and the risk of dementia as we traverse the journey of aging. Moreover, the study unveiled an enchanting connection—a higher phosphatidylcholine intake correlated with enhanced cognitive performance.

The Finnish Men and Their Journey: Unravelling the Tale

The study’s narrative commences with approximately 2,500 Finnish men, aged 42 to 60. These subjects opened the door to their dietary habits, lifestyles, and health journeys. The canvas broadened—hospital records, causes of death, medication reimbursement records—all intricately woven into a tapestry of data, spanning 22 years.

Cognition Under the Microscope: Insights Unveiled

Four years into the study’s initiation, nearly 500 men undertook tests designed to measure memory and cognitive processing. The journey’s plot deepened—337 men encountered dementia. A revelation emerged—the risk of dementia stood 28% lower in those who embraced a diet rich in phosphatidylcholine. As the curtains unveiled their story, men with elevated phosphatidylcholine intake showcased not just a shield against dementia but also mastery over memory and linguistic prowess.

The Key to Cognitive Well-being: Choline in Focus

Choline emerged as the star of this cognitive saga. A treasure trove of memory preservation and cognitive vigor, it weathered meticulous scrutiny. The study’s canvas encompassed a spectrum of factors, ranging from lifestyle to nutrition—a thorough examination of dementia’s risk factors. Even the enigmatic APOE4 gene, a sentinel of Alzheimer’s predisposition, found its place in the narrative, revealing no significant sway over the findings. The researchers’ verdict resounded—higher phosphatidylcholine intake offered a fortress against dementia, ushering in a symphony of cognitive brilliance in Eastern Finnish men.

The Choline Quandary: A Glance at the American Reality

Across the ocean, the American tale unfolds, casting a spotlight on choline consumption. Startling facts emerge—most adults fall short of the recommended choline intake, prescribed by the US Food and Nutrition Board. The decree stands—550 mg daily for men and 425 mg for women. The canvas offers a portrait—average daily choline intake in adults spans 402 mg in men and 278 mg in women.

Charting the Course to Cognitive Health: Foods Rich in Choli

A chart surfaces, adorned with the bounty of choline found in common, healthful foods. Beef, egg yolk, and beef liver beckon from the high choline ranks, yet caution flags arise due to their links with health issues. A symphony of alternatives emerges—soybeans, chicken breast, Atlantic cod, shiitake mushrooms, and more—each harboring respectable choline content.

A Personal Approach: Nourishing Cognitive Wellness

On a personal note, the journey veers towards a daily ritual—an intake of 1-2 lecithin capsules, each harboring 1200 mg of lecithin. In this elixir of wellness, phosphatidylcholine thrives, nurturing the cognitive garden.

Epilogue: Nurturing Cognitive Brilliance

As the narrative reaches its culmination, the tapestry of choline’s impact emerges in vivid hues. A testament to memory, cognition, and the quest for a vibrant mind, this tale is etched with the threads of scientific exploration. Yet, wisdom’s voice reverberates—consult the guide, the physician, for personalized steps towards cognitive well-being.

References:

 

Main Reference

  1. Maija P T Ylilauri, Sari Voutilainen, Eija Lönnroos, Heli E K Virtanen, Tomi-Pekka Tuomainen, Jukka T Salonen, Jyrki K Virtanen. Associations of dietary choline intake with risk of incident dementia and with cognitive performance: the Kuopio Ischaemic Heart Disease Risk Factor Study. The American Journal of Clinical Nutrition, 2019,  https://academic.oup.com/ajcn/advance-article-abstract/doi/10.1093/ajcn/nqz148/5540729?redirectedFrom=fulltext
  2. Choline Requirements and Average Intake: National Institutes of Health – Office of Dietary Supplements https://ods.od.nih.gov/factsheets/Choline-HealthProfessional/
Eat Smart, Live Well, Look Great,
 

Dr. Meschino

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

Adeeva Supplements
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LMU 60 – Empowering Brain Health: Lifestyle and Nutrient Factors in Dementia Prevention

Nine Lifestyle Factors Shown to be Responsible for 35% of Dementia Cases

LMU 60 – Empowering Brain Health: Lifestyle and Nutrient Factors in Dementia Prevention

Lifestyle Medicine Update (July 29, 2017)

Introduction:

Dementia, with Alzheimer’s disease as its most usual form, poses a significant global health concern. A study presented at the Alzheimer’s Association International Conference on July 20, 2017, and simultaneously published in The Lancet, unveiled an intriguing insight into the factors that contribute to dementia. Surprisingly, nine lifestyle elements were found to be accountable for 35% of all dementia cases worldwide. This revelation underscores the pivotal role of lifestyle choices in the realm of brain health.

Lifestyle Factors and Dementia: Unveiling the Nine

The nine lifestyle factors identified as catalysts for dementia are a compelling wake-up call. These include:

  1. Incomplete Secondary Education: The early years of education emerged as a crucial determinant, with failure to complete secondary education found to be linked to increased dementia risk.
  2. High Blood Pressure: Uncontrolled hypertension was highlighted as a potent contributor to dementia.
  3. Midlife Obesity: The repercussions of obesity during midlife resonated as a factor that amplifies the risk of dementia.
  4. Midlife Hearing Loss: A subtle yet impactful association was established between midlife hearing loss and heightened dementia risk.
  5. Smoking: The perils of smoking emerged as an influential lifestyle element that enhances the vulnerability to dementia.
  6. Depression: The link between depression and dementia reinforced the intricate interplay of mental health and cognitive well-being.
  7. Physical Inactivity: A sedentary lifestyle was identified as a significant precursor to dementia, emphasizing the importance of staying active.
  8. Social Isolation: The consequences of social isolation echoed as a concerning factor that contributes to dementia.
  9. Diabetes in Later Life: The correlation between diabetes in later stages of life and dementia risk underscored the significance of managing diabetes for cognitive health.

Beyond the Nine: Uncharted Terrain

It is noteworthy that the study refrained from incorporating dietary factors, alcohol consumption, visual impairment, air pollution, and sleep practices. Consequently, the 35% attributed to lifestyle factors may be a conservative estimate, as one researcher implies. The influence of these unexplored dimensions could potentially elevate the significance of lifestyle choices in the prevention of dementia.

Nutrients and Cognitive Health: A Glimpse into the Future

The pursuit of cognitive well-being extends beyond lifestyle factors to encompass specific nutrients. Recent scientific reviews underscore the role of select nutrients in memory preservation, focus enhancement, and mood regulation.

Omega-3 fats garnered attention for their cognitive benefits, with a meta-analysis from 2015 demonstrating their positive impact on cognitive health. Omega-3 supplementation, particularly with daily DHA doses exceeding 1 gram, displayed improvements in cognitive function among older adults. Moreover, omega-3 fats complement drug therapy in depression treatment, establishing their dual role in mental health.

Phosphatidylserine, a noteworthy supplement, showcased potential in dementia and cognitive dysfunction alleviation. The FDA’s cautious endorsement reflects the evolving research landscape, allowing for the assertion that phosphatidylserine may mitigate dementia risk.

CDP-choline supplements surfaced as promising interventions to counter early-stage cognitive decline. Choline’s role in acetylcholine production, a memory-related neurotransmitter, solidifies its significance in preserving cognitive vitality.

B-vitamin supplementation, particularly folic acid, vitamin B12, vitamin B6, and vitamin B3-niacin, exhibited brain health benefits. Their efficacy in curtailing age-related brain shrinkage and lowering homocysteine levels, a molecule linked to Alzheimer’s development, underscore their relevance.

Antioxidants such as vitamin C and vitamin E exhibited potential in reducing cognitive impairment risk, while emerging nutrients like lutein and magnesium emerged as preventives against age-related cognitive decline.

In an Indian context, Bacopa Monnieri demonstrated remarkable efficacy in early-stage memory loss treatment, rivalling dementia medications. The adaptogen herb Ashwagandha and melatonin supplementation showcased preliminary promise in reversing mild cognitive impairment and fostering sleep, respectively.

A Holistic Approach to Dementia Prevention

Dementia prevention extends beyond the brain to encompass overall health. Ensuring ideal blood cholesterol levels to prevent cerebrovascular disease, averting head injuries, and head trauma assumes a pivotal role. However, the crux of dementia prevention rests in embracing a proactive stance towards lifestyle modification and nutrient integration. Empowering brain health involves nurturing cognitive well-being through education, sound health practices, and a nutrient-rich diet.

References

  1. http://www.medscape.com/viewarticle/883211?nlid=116875_1842&src=WNL_mdplsfeat_170725_mscpedit_wir&uac=62515BJ&spon=17&impID=1396748&faf=1#vp_1
  2. http://www.aljazeera.com/news/2017/07/lifestyle-cut-dementia-risk-lancet-170720072645780.html
  3. http://www.nutraingredients-usa.com/Ingredients/Probiotics-prebiotics/The-top-ingredients-for-cognition-focus-mood?utm_source=newsletter_product&utm_medium=email&utm_campaign=25-Jul-2017&c=LwVSym2olBn%2B3sEAtgq7rzCtF2G6qEVs&p2=
Eat Smart, Live Well, Look Great
 

Dr. Meschino

Introduction

Dementia, with Alzheimer’s disease as its most usual form, poses a significant global health concern. A study presented at the Alzheimer’s Association International Conference on July 20, 2017, and simultaneously published in The Lancet, unveiled an intriguing insight into the factors that contribute to dementia. Surprisingly, nine lifestyle elements were found to be accountable for 35% of all dementia cases worldwide. This revelation underscores the pivotal role of lifestyle choices in the realm of brain health.

Lifestyle Factors and Dementia: Unveiling the Nine

The nine lifestyle factors identified as catalysts for dementia are a compelling wake-up call. These include:

  1. Incomplete Secondary Education: The early years of education emerged as a crucial determinant, with failure to complete secondary education found to be linked to increased dementia risk.
  2. High Blood Pressure: Uncontrolled hypertension was highlighted as a potent contributor to dementia.
  3. Midlife Obesity: The repercussions of obesity during midlife resonated as a factor that amplifies the risk of dementia.
  4. Midlife Hearing Loss: A subtle yet impactful association was established between midlife hearing loss and heightened dementia risk.
  5. Smoking: The perils of smoking emerged as an influential lifestyle element that enhances the vulnerability to dementia.
  6. Depression: The link between depression and dementia reinforced the intricate interplay of mental health and cognitive well-being.
  7. Physical Inactivity: A sedentary lifestyle was identified as a significant precursor to dementia, emphasizing the importance of staying active.
  8. Social Isolation: The consequences of social isolation echoed as a concerning factor that contributes to dementia.
  9. Diabetes in Later Life: The correlation between diabetes in later stages of life and dementia risk underscored the significance of managing diabetes for cognitive health.

Beyond the Nine: Uncharted Terrain

It is noteworthy that the study refrained from incorporating dietary factors, alcohol consumption, visual impairment, air pollution, and sleep practices. Consequently, the 35% attributed to lifestyle factors may be a conservative estimate, as one researcher implies. The influence of these unexplored dimensions could potentially elevate the significance of lifestyle choices in the prevention of dementia.

Nutrients and Cognitive Health: A Glimpse into the Future

The pursuit of cognitive well-being extends beyond lifestyle factors to encompass specific nutrients. Recent scientific reviews underscore the role of select nutrients in memory preservation, focus enhancement, and mood regulation.

Omega-3 fats garnered attention for their cognitive benefits, with a meta-analysis from 2015 demonstrating their positive impact on cognitive health. Omega-3 supplementation, particularly with daily DHA doses exceeding 1 gram, displayed improvements in cognitive function among older adults. Moreover, omega-3 fats complement drug therapy in depression treatment, establishing their dual role in mental health.

Phosphatidylserine, a noteworthy supplement, showcased potential in dementia and cognitive dysfunction alleviation. The FDA’s cautious endorsement reflects the evolving research landscape, allowing for the assertion that phosphatidylserine may mitigate dementia risk.

CDP-choline supplements surfaced as promising interventions to counter early-stage cognitive decline. Choline’s role in acetylcholine production, a memory-related neurotransmitter, solidifies its significance in preserving cognitive vitality.

B-vitamin supplementation, particularly folic acid, vitamin B12, vitamin B6, and vitamin B3-niacin, exhibited brain health benefits. Their efficacy in curtailing age-related brain shrinkage and lowering homocysteine levels, a molecule linked to Alzheimer’s development, underscore their relevance.

Antioxidants such as vitamin C and vitamin E exhibited potential in reducing cognitive impairment risk, while emerging nutrients like lutein and magnesium emerged as preventives against age-related cognitive decline.

In an Indian context, Bacopa Monnieri demonstrated remarkable efficacy in early-stage memory loss treatment, rivalling dementia medications. The adaptogen herb Ashwagandha and melatonin supplementation showcased preliminary promise in reversing mild cognitive impairment and fostering sleep, respectively.

A Holistic Approach to Dementia Prevention

Dementia prevention extends beyond the brain to encompass overall health. Ensuring ideal blood cholesterol levels to prevent cerebrovascular disease, averting head injuries, and head trauma assumes a pivotal role. However, the crux of dementia prevention rests in embracing a proactive stance towards lifestyle modification and nutrient integration. Empowering brain health involves nurturing cognitive well-being through education, sound health practices, and a nutrient-rich diet.

References

  1. http://www.medscape.com/viewarticle/883211?nlid=116875_1842&src=WNL_mdplsfeat_170725_mscpedit_wir&uac=62515BJ&spon=17&impID=1396748&faf=1#vp_1
  2. http://www.aljazeera.com/news/2017/07/lifestyle-cut-dementia-risk-lancet-170720072645780.html
  3. http://www.nutraingredients-usa.com/Ingredients/Probiotics-prebiotics/The-top-ingredients-for-cognition-focus-mood?utm_source=newsletter_product&utm_medium=email&utm_campaign=25-Jul-2017&c=LwVSym2olBn%2B3sEAtgq7rzCtF2G6qEVs&p2=

Eat Smart, Live Well, Look Great

Dr. Meschino

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 48 – Unveiling the Epigenetic Shield: Broccoli’s Sulfurophane Emerges as a Potent Anti-Cancer Agent

ulfurophane (from broccoli) Shown to Decrease Cancer

LMU 48 – Unveiling the Epigenetic Shield: Broccoli's Sulfurophane Emerges as a Potent Anti-Cancer Agent

Source: The Journal of Nutritional Biochemistry (April 2017)

Lifestyle Medicine Update (March 25, 2017)

Introduction

In the pursuit of understanding the intricate connections between diet and disease prevention, a groundbreaking study published in the April 2017 edition of the Journal of Nutritional Biochemistry has illuminated a remarkable revelation. This study adds to the growing body of evidence supporting the cancer-fighting potential of a natural compound found in cruciferous vegetables such as broccoli, cabbage, cauliflower, Bok choy, Brussels sprouts, and turnips. The study’s remarkable discovery uncovers sulfurophane, a powerful compound found in these vegetables, as an influential epigenetic player that exerts significant inhibitory effects on the formation of human prostate cancer cells. This finding not only advances our understanding of the potent anti-cancer properties of sulfurophane but also opens doors to broader implications for cancer prevention.

Diving into the Study

The study featured in the April 2017 edition of the Journal of Nutritional Biochemistry underscores the profound impact of sulfurophane on cancer development. This unique compound, obtained from cruciferous vegetables, exhibited a pivotal epigenetic effect that suppressed the formation of human prostate cancer cell colonies. Notably, this marks the first time such an epigenetic modulation has been attributed to sulfurophane. This breakthrough insight ignites new avenues for exploring the compound’s potential in mitigating other cancers linked to similar epigenetic pathways, including those affecting the brain, lungs, colon, breast, stomach, and chronic lymphocytic leukemia.

Epigenetic Precision

The study unfolds against a backdrop of recent investigations into a specific long, non-coding RNA called LINC01116. This RNA, which is highly up-regulated in a common variant of human prostate cancer, wields direct genetic effects that contribute to cancer development. The April 2017 study sheds light on sulfurophane’s unique ability to mitigate this cancer-promoting RNA, effectively normalizing its expression. As a result, the study reported a remarkable four-fold reduction in the formation of prostate cancer cell colonies. Moreover, the study offers intriguing insight into the association between increased consumption of cruciferous vegetables and a reduced risk of developing prostate cancer. By rectifying the impact of this epigenetic factor, sulfurophane-rich vegetables offer a potent means of lowering prostate cancer risk.

Unveiling the Epigenetic Orchestra

The emergence of long, non-coding RNA as a critical epigenetic influencer defies past perceptions of junk DNA. Traditionally dismissed as genetic remnants, this non-coding RNA now stands as a powerful conductor, orchestrating genetic expression and behavior. Like how computer software dictates hardware functionality, the body’s epigenetic activities guide our DNA’s actions, toggling genes on and off and even moulding gene structure and function in response to environmental changes, nutritional status, and toxin exposure.

This study delves into the specific mechanism of sulfurophane’s intervention, highlighting its role in influencing this intricate epigenetic symphony. By attenuating the activity of the LINC01116 long, non-coding RNA, sulfurophane charts a course towards cancer prevention by curbing gene expressions associated with cancer development.

Practical Implications

The profound implications of this study reverberate through our dietary choices and their potential impact on cancer prevention. Cruciferous vegetables, lauded for their diverse health benefits, emerge as epigenetic allies in the battle against cancer. Encouraging individuals to include these vegetables in their diets a minimum of three times weekly becomes a prudent strategy. The daily consumption of these nutrient-rich foods fosters epigenetic harmony, thus fortifying defence mechanisms against various cancers.

Conclusion

The Journal of Nutritional Biochemistry’s April 2017 study illuminates the groundbreaking potential of sulfurophane, a component found in cruciferous vegetables, in mitigating cancer risk through epigenetic modulation. As the curtain rises on a new era of precision medicine, wherein epigenetic influences are harnessed to steer genetic expression, sulfurophane stands as a promising protagonist. Armed with this knowledge, individuals can embrace dietary choices that align with epigenetic harmony, reducing their vulnerability to cancers and promoting overall health.

References

  1. (Main Reference): Beaver L.M., Kuintzle R, Buchanan A, Wiley MW, Glasser S.T. et al. JNB (the journal of nutritional biochemistry) April 2017, vol 42:72-83
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141106/
  2. https://www.sciencedaily.com/releases/2017/03/170316141117.htm

Eat Smart, Live Well, Look Great,

Dr. Meschino

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

Adeeva Supplements
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LMU 11 – Slowing Brain Shrinkage with Vitamin B12: A Key to Preventing Alzheimer’s and Cognitive Decline

LMU-11

LMU 11 – Slowing Brain Shrinkage with Vitamin B12: A Key to Preventing Alzheimer's and Cognitive Decline

Source: Journal of the American Medical Association (June, 2016)

Lifestyle Medicine Update (June 4, 2016)

Introduction:

As we age, one of the concerning aspects is the shrinking of the brain, which is associated with an increased risk of Alzheimer’s disease and cognitive impairment. However, recent research on the neuroprotective effects of vitamin B12 has shed light on a potential solution to this problem. This article explores the findings of significant studies that highlight the role of vitamin B12 in slowing brain shrinkage and reducing the risk of dementia and Alzheimer’s disease.

Evidence from the JAMA-Psychiatry Study

A pivotal study published in June 2016 in the Journal of the American Medical Association – Psychiatry presented compelling evidence of the impact of vitamin B12 on brain shrinkage. The research followed 501 subjects aged 60 years and older, without dementia at the study’s onset, from 2001 to 2009. During the six-year follow-up, 299 subjects underwent routine MRI imaging of their brains. The results were striking, indicating that individuals with higher blood levels of vitamin B12 exhibited a significant decrease in the rate of brain tissue volume loss compared to those with lower levels of the vitamin.

The Neuroprotective Mechanisms of Vitamin B12

The protective effects of vitamin B12 on the brain are multifaceted. Firstly, it directly prevents the loss of brain cells, thereby slowing brain shrinkage. Additionally, vitamin B12 reduces the levels of homocysteine in the blood. Elevated homocysteine has been linked to brain shrinkage and an increased risk of Alzheimer’s disease in numerous studies. Thus, the ability of vitamin B12 to lower homocysteine levels presents a complementary pathway through which it may mitigate brain atrophy.

Insights from White Matter Hyperintensity

The 2016 JAMA-Psychiatry study also explored the association between vitamin B12 levels, homocysteine levels, and White Matter Hyperintensity (WMI) on MRI scans. The results revealed that individuals with lower vitamin B12 levels and higher homocysteine levels demonstrated increased WMI, strongly linked to heightened risks of cognitive decline and other mental health disorders. Considering that mild cognitive impairment (MCI) often precedes Alzheimer’s disease, these findings highlight the potential significance of vitamin B12 in early intervention strategies.

The Oxford Project to Investigate Memory and Aging (OPTIMA) and VITACOG Study

The OPTIMA and VITACOG studies focused on individuals over 70 with pre-existing MCI. Half of the participants were given a B-vitamin supplementation regimen consisting of folic acid (800 mcg), vitamin B12 (500 mcg), and vitamin B6 (20 mg) daily for two years, while the other half received a placebo. Remarkably, the group receiving B-vitamin supplementation experienced a 30% average reduction in brain shrinkage, and in some cases, the drop reached up to 53%. Moreover, cognitive tests demonstrated that the rate of brain shrinkage correlated with the pace of cognitive decline.

The Significance of Slowing Brain Atrophy

Slowing brain shrinkage or atrophy is crucial to preserving cognitive function as we age. The average brain shrinkage rate for individuals over 60 without MCI is 0.5% annually. In contrast, those with MCI have a brain shrinkage rate of 1%, while Alzheimer’s patients exhibit an average brain shrinkage rate of 2.5% annually. Consequently, any intervention that can mitigate brain atrophy holds great potential for enhancing healthy life expectancy and overall quality of life.

Conclusion

The evidence presented in various research studies suggests that vitamin B12 is pivotal in slowing brain shrinkage, reducing the risk of Alzheimer’s disease, and preserving cognitive function. While drug-based interventions for this purpose are yet to yield significant results, B-vitamin supplementation has shown promising effects in clinical studies. It is, therefore, prudent for individuals to monitor their blood levels of homocysteine, vitamin B12, and red blood cell folic acid levels and consider a simple B-vitamin supplementation regimen to support brain health and combat age-related cognitive decline.

References:

  1. Medscape, May 11, 2016 (http://www.medscape.com/viewarticle/863157)
  2. JAMA-Psychiatry, June 2016 (http://archpsyc.jamanetwork.com/article.aspx?articleid=2517517)
  3. VITACOG study, September 2010 (http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0012244)
Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

Adeeva Supplements