Category: Vitamin

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LMU 170 – Vitamin D: Your Secret Weapon Against Cancer

LMU-170

LMU 170 – Vitamin D: Your Secret Weapon Against Cancer

Source: Journal of the American Medical Association (2017)

Lifestyle Medicine Update (August 20, 2020)

Introduction:

In a world where health is paramount, a 2017 study in the Journal of the American Medical Association unveiled a hidden guardian: vitamin D. This research, focused on postmenopausal women, defied conventional wisdom, revealing that maintaining vitamin D levels above 82.5 nmol/L (33 ng/ml) reduces cancer risk by 30%. As we explore this revelation, we embark on a journey to understand the potent role of vitamin D in shielding us from one of the most formidable health threats: cancer.
 

The Vitamin D Revelation

In 2017, a groundbreaking study published in the Journal of the American Medical Association resurfaced the crucial connection between vitamin D and cancer risk. This research shed light on a vital aspect of vitamin D: its role in protecting us from one of the most formidable adversaries of our health – cancer. The study’s findings were nothing short of astonishing, suggesting that our blood levels of this essential vitamin play a pivotal role in safeguarding us against this relentless disease.

The Magic Number: 82.5 nmol/L

While most government recommendations stipulate that a vitamin D blood level ranging from 50-80 nmol/L (20-32 ng/ml) is sufficient for maintaining a healthy vitamin D status, this study introduced a game-changing perspective. According to the researchers, the threshold for optimal protection against cancer lies at a vitamin D blood level of at least 82.5 nmol/L (33 ng/ml). They firmly contested the prevailing recommendations and made a compelling case for a more proactive approach to vitamin D intake.

Unveiling the Study

This comprehensive four-year study enrolled over 2,000 postmenopausal women aged fifty-five and older hailing from thirty-one counties in Nebraska. These women were randomly assigned to one of two groups: a daily regimen of 2000 international units (IU) of vitamin D3 along with 1500 mg of calcium or identical placebos. The study’s primary focus was to evaluate the impact of vitamin D on cancer risk, particularly in postmenopausal women.

The results were astonishing: women who maintained blood vitamin D levels at or above 82.5 nmol/L (33 ng/ml) enjoyed a 30% lower risk of cancer compared to their counterparts whose vitamin D levels fell below this crucial threshold. The implications were clear; achieving and maintaining optimal vitamin D levels in the blood could be an instrumental factor in reducing one’s risk of cancer.

The Science Behind the Shield

So, what is the science behind vitamin D’s protective mantle against cancer? As one of the researchers, Joan Lappe, explains, vitamin D is a vital player in the proper functioning of most cells in the human body. Without adequate vitamin D, cells are more susceptible to transformations that lead to malignancy. Vitamin D operates as a sentinel, guarding cells against unwarranted changes that could set the stage for cancer development.

Moreover, it’s essential to consider the context in which we obtain our vitamin D. While our skin can produce vitamin D when exposed to sunlight, the widespread use of sunscreen products effectively hinders this natural process. In addition, the modern lifestyle, which often keeps individuals indoors, further contributes to suboptimal vitamin D levels.

Taking Action

Given the profound implications of this study, the takeaway is clear: take charge of your health by having your blood vitamin D levels assessed by your healthcare provider. If your levels fall below the critical threshold of 82.5 nmol/L (33 ng/ml), it’s time to consider a supplementation program. This proactive step could potentially reduce your overall cancer risk by an impressive 30%, aligning with the findings of this and other impactful studies.

In the battle against cancer, knowledge is power. Armed with the understanding of vitamin D’s role in this fight, you can take concrete steps to safeguard your health. Consider this revelation as a potent reminder that sometimes, a humble vitamin can be your most robust ally against formidable foes.

References:

  1. Main Reference: Joan Lappe, Patrice Watson, Dianne Travers-Gustafson, Robert Recker, Cedric Garland, Edward Gorham, Keith Baggerly, Sharon L. McDonnell. Effect of Vitamin D and Calcium Supplementation on Cancer Incidence in Older Women. JAMA, 2017 [Read the Study](https://jamanetwork.com/journals/jama/fullarticle/2613159)
  2. JoAnn E. Manson, Shari S. Bassuk, Julie E. Buring. Vitamin D, Calcium, and Cancer. JAMA, 2017; 317 (12): 1217 [Read the Study](https://jamanetwork.com/journals/jama/article-abstract/2613138)
  3. [ScienceDaily: Higher vitamin D levels associated with lower cancer risk, study suggests](https://www.sciencedaily.com/releases/2017/03/170328120835.htm)
 
Eat Smart, Live Well, Look Great,
 

Dr. Meschino

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 166 – Vitamin D: The Immune Defender Against COVID-19

LMU-166

LMU 166 – Vitamin D: The Immune Defender Against COVID-19

Source: Journal Aging Clinical and Experimental Research (May 2020)

Lifestyle Medicine Update (June 4, 2020)

Introduction:

In the battle against viral-induced respiratory infections, vitamin D has emerged as a potent ally, especially in the context of COVID-19. This article explores the critical role of vitamin D, the optimal levels needed for immune defense, regional disparities in vitamin D status, its connection to immunity and lung health, and how to strike the right balance through supplementation. Discover how this unassuming nutrient can strengthen our defenses in challenging times.

The Crucial Role of Vitamin D

In recent times, the spotlight has shifted to an unsung hero in the battle against respiratory infections: vitamin D. As research unfolds, it’s becoming increasingly evident that maintaining optimal levels of this vital nutrient can be a game-changer in our defence against viral-induced respiratory tract infections, including the dreaded COVID-19.

The Vitamin D Threshold

To understand the significance of vitamin D, it’s essential to establish a baseline. Studies have shown that individuals with a blood vitamin D level above 75 or 80 nmol/L (and below 140 nmol/L) are better equipped to prevent viral-induced respiratory tract infections or mitigate their severity if they do occur.

The European Calcified Tissue Society Working Group has defined “severe vitamin D deficiency” as a blood vitamin D level below 30 nmol/L. To put things in perspective, an ideal vitamin D value falls between 80 and 140 nmol/L, offering a robust shield against infections.

Regional Disparities in Vitamin D

The Seneca study shed light on vitamin D levels in different regions. It revealed that older individuals in Spain and Italy had average vitamin D blood levels of 26 nmol/L and 28 nmol/L, respectively. Contrast this with Nordic countries boasting levels of 45 nmol/L or higher. In Switzerland, nursing home residents registered an average vitamin D level of 23 nmol/L, while a staggering 76% of Italian women over 70 had vitamin D levels below the 30 nmol/L deficiency threshold.

What’s striking is the correlation between these countries with lower vitamin D levels and a high number of COVID-19 cases. Moreover, the elderly, who are most susceptible to severe COVID-19 outcomes, tend to have even lower vitamin D status due to decreased sun exposure and declining skin synthesis capability with age.

The Sunlight Connection

Sunlight plays a pivotal role in vitamin D synthesis in our skin. Southern European countries, known for preferring shade in the intense sun, coupled with darker skin, witness reduced skin production of vitamin D compared to their Northern European counterparts. In the north, where sunlight is scarce for a significant portion of the year, vitamin D supplementation and fortification of dairy products are commonplace practices.

Vitamin D and Immunity

The relationship between vitamin D and immunity is multi-faceted. Various immune cells rely on vitamin D to defend against harmful viruses and bacteria effectively. Moreover, adequate vitamin D levels help modulate immune responses, preventing immune cells from overreacting and triggering a cytokine storm – a life-threatening event often responsible for organ failure in severe infections.

The Lung Defender

In addition to its role in immunity, vitamin D also emerges as a crucial player in lung health. It regulates the function of Angiotensin Converting Enzyme-2 (ACE2) enzymes in the lungs, acting as a barrier against highly virulent and destructive respiratory tract infections. This newfound understanding underscores the importance of maintaining optimal vitamin D levels, especially during the COVID-19 era.

Striking the Vitamin D Balance

The key question now is how to strike the right vitamin D balance. For most individuals, aiming for a blood vitamin D level between 80 and 140 nmol/L is ideal. Achieving this can often be as simple as taking 1,000 to 3,000 IU of vitamin D per day.

However, it’s crucial to approach vitamin D supplementation with caution and under the guidance of a healthcare professional. Everyone’s needs are unique, and factors like autoimmune diseases or certain cancers may necessitate higher vitamin D levels. Regular monitoring through blood tests ensures that you stay within the optimal range.

Understanding Vitamin D Measurements

In some instances, blood panels express vitamin D levels in ng/ml rather than nmol/L. To align with this convention, the sweet spot to target is between 32 and 56 ng/ml.

Conclusion 

vitamin D is a formidable ally in our ongoing battle against respiratory infections, especially COVID-19. By maintaining optimal vitamin D levels, we fortify our immune defences and bolster our lung health. As we navigate these challenging times, let us remember the power of this unassuming nutrient and harness it to protect ourselves and our loved ones.

Reference:

  1. Petre Cristian Ilie, Simina Stefanescu, Lee Smith. The role of vitamin D in the prevention of coronavirus disease 2019 infection and mortality. Aging Clinical and Experimental Research, 2020.                                                                                                                                                         [Read the Study](https://link.springer.com/article/10.1007/s40520-020-01570-8)
 
Eat Smart, Live Well, Look Great,

Dr. Meschino

In May 2020, an updated report was published in the journal Aging Clinical and Experimental Research, which highlighted the increasingly strong link between low vitamin D levels and increased risk of death from Covid-19. The researcher explains that The European Calcified Tissue Society Working Group has defined “severe vitamin D deficiency” as a blood vitamin D level lower than 30 nmol/L. So, anything below 30 nmol/L is considered a severe deficiency of vitamin D. Remember that an ideal value is between 80 and 140nmol/L.

The Seneca study showed that the average vitamin D blood level in older individuals in Spain is 26 nmol/L and in Italy, it’s 28 nmol/, whereas higher levels of 45 nmol/L are found in Nordic countries. In Switzerland, the average vitamin D level is 23 nmol/L in nursing homes and in Italy, 76% of women over 70 years of age have vitamin D levels below 30 nmol/L. These are the countries with a high number of cases of COVID-19 and the aging population is the group with the highest risk for morbidity and mortality from the Covid-19 virus. The researchers state that vitamin D deficiency is a major public health problem worldwide in all age groups, but vitamin D status deteriorates with age, above 70 years of life, due to decreased sun exposure and decreased ability of the skin to synthesize vitamin D from sunlight exposure. Vitamin D status is especially poor in institutionalized people (people in nursing homes) 75% of them being severely vitamin D deficient, with blood vitamin D levels below 25 nmol/L. The researchers go on to state that the Southern European countries have lower blood levels of vitamin D, compared to Northern European countries because of decreased sun exposure (prefer the shade in the strong sun) and they tend to have darker skin, compared to Northern Europeans), which reduces the amount of vitamin D made in the skin upon exposure to sunlight. Northern Europe’s average vitamin D blood levels are higher because they know that they don’t get adequate sunlight enough of the year to synthesize required amounts of vitamin D to prevent osteoporosis, so they consume cod liver oil and they take vitamin D supplements (which are very inexpensive) and they fortify their milk and milk products with vitamin D (Finland).

Regarding immunity, vitamin D is required by various immune cells to ward off and fight dangerous viruses and bacteria. As well, low vitamin D blood levels enable certain immune cells to over-react to viruses by creating the cytokine storm, which is often the life-threatening event that causes organ failure and death. Vitamin D also modulates the function of the ACE enzymes in the lungs (Angiotensin Converting Enzyme-2), helping to prevent the virus from mounting a highly virulent and permanent lung-damaging respiratory tract infection in the lungs. I believe that it is just common sense at this point to ensure that your blood vitamin D level is above 75 or 80 nmol/L and below 140 nmol/L. If you have an autoimmune disease or you are fighting certain types of cancer your doctor may want to see higher blood vitamin D levels than 140 nmol/L, but for most people between 80 and 140 nmol/L is the sweet spot to shoot for. Most people can achieve this value by taking 1,000 to 3,000 IU of vitamin D per day.

But you should get your blood vitamin D level assessed by your physician to make sure you are getting enough vitamin D each day to achieve a blood level of at least 80 nmol/L but not so much as to go beyond 140 nmol/L unless otherwise indicated by your physician. Some blood panels show vitamin D in ng/ml rather than nmol/L, in which case the sweet spot is between 32 and 56 ng/ml.

I have included the reference for this information in the text below.

References:

Petre Cristian Ilie, Simina Stefanescu, Lee Smith. The role of vitamin D in the prevention of coronavirus disease 2019 infection and mortality. Aging Clinical and Experimental Research, 2020.
https://link.springer.com/article/10.1007/s40520-020-01570-8

Eat Smart, Live Well, Look Great,

Dr. Meschino

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 165 – The Unsung Hero: Vitamin C and Neutrophils in Immune Health

LMU-165

LMU 165 – The Unsung Hero: Vitamin C and Neutrophils in Immune Health

Source: Multiple Peer-reviewed Medical and Scientific Journals (see references below)

Lifestyle Medicine Update (May 30, 2020)

Introduction:

Uncover the critical role of vitamin C in supporting neutrophils, our immune system’s rapid responders. Neutrophils, essential for defense against infections, rely on vitamin C to function effectively. This article explores how vitamin C empowers neutrophils, the consequences of deficiency, and proactive strategies for immune health, offering valuable insights into bolstering our body’s defenses.

 

A Closer Look at Neutrophils 

In the intricate dance of our immune system, one group of foot soldiers stands out: neutrophils. These tiny yet mighty cells patrol our bloodstream, ready to defend against any foreign invaders that dare to threaten our well-being. Neutrophils are an essential part of the innate immune system, an evolutionary masterpiece that requires no prior training to combat threats effectively.

Neutrophils’ Swift Response

Neutrophils are the rapid responders of our immune system. As soon as they sense a threat – be it a virus or bacteria – these vigilant cells spring into action. They don’t hesitate; they engulf and destroy the invaders on sight, including the notorious coronaviruses.

Neutrophils’ Secret Weapon – Vitamin C

Here’s the captivating twist in this story: neutrophils rely heavily on vitamin C to carry out their mission. This vital nutrient is their secret weapon. Neutrophils use vitamin C to migrate to the sites in our bodies where viruses or bacteria have taken refuge, primarily our lungs, ground zero for respiratory infections.

Not only do they need vitamin C for mobilization, but they also use it to engulf viruses and bacteria, turning them into harmless prey. Moreover, vitamin C equips neutrophils with the power to generate free radicals, which are potent virus and bacteria killers.

The Vitamin C Delivery System

Picture this: specialized pumps in the outer layer of neutrophils’ skin function as gatekeepers, ushering vitamin C from our bloodstream into the core of these infection-fighting cells. This intricate mechanism ensures that neutrophils have ample vitamin C to fulfil their crucial roles.

The Role of Vitamin C Intake

Optimizing vitamin C intake is essential for maintaining robust neutrophil function and overall immune health. Studies have shown that a daily intake of 200 mg of vitamin C is sufficient for young, healthy individuals to maintain a minimum blood vitamin C level of 50 umol/L – a level associated with optimal immune function.

However, as we age, our vitamin C requirements evolve. For those over 60, researchers recommend 1000 mg of vitamin C per day, ideally split into two doses. These adjustments account for the natural decline in vitamin C absorption and utilization that accompanies aging.

Vitamin C in the Face of Infection

When confronted with a respiratory tract infection, be it the common cold, flu, or something more sinister like COVID-19, neutrophils undergo a dramatic change. They deplete their vitamin C reserves at an astonishing rate. To keep their infection-fighting capabilities at their peak, they require a substantial influx of vitamin C.

Studies underscore the significance of this need. Gram doses of vitamin C become necessary once an infection takes hold, leading to peak plasma ascorbate concentrations of greater than 150 µmol/L – a desirable level during an infection.

The Consequences of Vitamin C Deficiency

When neutrophils are deprived of sufficient vitamin C, they resort to an alternative defence mechanism: the release of fibrous strands known as NETs (Neutrophil Extracellular Traps). While NETs can capture and neutralize viruses, they come at a steep cost. They trigger an immune cascade, resulting in a cytokine storm – a vicious cycle of inflammation that can lead to organ failure and abnormal blood clotting.

Recent studies offer a glimmer of hope. Providing sepsis patients with high-dose vitamin C supplementation has shown promising results in preventing deaths. However, waiting until infection reaches this advanced stage may not be the wisest approach.

The Proactive Approach to Immune Health

Rather than leaving our immune system vulnerable, it’s wiser to take a proactive stance. Supporting neutrophil function by maintaining adequate vitamin C levels is a simple yet effective strategy. For those in good health, a daily intake of 200-1000 mg of vitamin C can bolster immune readiness.

Vigilance in Times of Infection

In the face of an impending respiratory tract infection, vigilance is key. At the first sign of trouble, be it a scratchy throat or sniffles, consider a minimum daily dosage of 500 mg of vitamin C, split into four doses. This regimen has demonstrated its ability to support neutrophil function, deter the release of NETs, and prevent a dangerous cytokine storm.

In conclusion, the bond between vitamin C and neutrophils in safeguarding our immune health is undeniable. With the wisdom of optimal vitamin C intake, we empower our immune system’s rapid responders to act decisively and protect us from the perils of infection.

References:

  1. Bozonet SM and Carr AC. The role of physiological vitamin C concentrations on key functions of neutrophils isolated from healthy individuals. Nutrients June 2019. 11,1363.
  2. [Link to Book Excerpt](https://books.google.ca/books?id=vc3LDwAAQBAJ&pg=PT149&lpg=PT149&dq=NETs+vitamin+C+and+neutrophils&source=bl&ots=HLGF1c86g_&sig=ACfU3U3eSCG30ickkzlMeGmd87bIfECJ6g&hl=en&sa=X&ved=2ahUKEwjJgqPZ0c_pAhVVZ80KHUhzBDgQ6AEwD3oECAkQAQ#v=onepage&q=NETs%20vitamin%20C%20and%20neutrophils&f=false)
  3. [Link to Research Article](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743982/)
  4. [Link to Research Article](https://ashpublications.org/blood/article/129/10/1357/36005/Platelets-and-neutrophil-extracellular-traps)
  5. [Link to Research Article](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950903/)
  6. [Link to Research Article](https://jamanetwork.com/journals/jama/fullarticle/2752063)
  7. [Link to Research Article](https://www.researchgate.net/publication/336201419_Effect_of_Vitamin_C_Infusion_on_Organ_Failure_and_Biomarkers_of_Inflammation_and_Vascular_Injury_in_Patients_With_Sepsis_and_Severe_Acute_Respiratory_Failure_The_CITRIS-ALI_Randomized_Clinical_Trial)
  8. [Link to Research Article](https://annalsofintensivecare.springeropen.com/articles/10.1186/s13613-020-0640-6)
  9.  [Link to News Article](https://www.news-medical.net/news/20191001/Vitamin-C-improves-survival-rate-in-sepsis-and-acute-respiratory-distress-syndrome-(ARDS).aspx)
 
Eat Smart, Live Well, Look Great,
 

Dr. Meschino

 

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 163 – The Sunshine Vitamin’s Silent Power: How Vitamin D Could Help Battle COVID-19

LMU-163

LMU 163 – The Sunshine Vitamin's Silent Power: How Vitamin D Could Help Battle COVID-19

Source: MedRxiv (April 2020) and the Irish Medical Journal (May 2020)

Lifestyle Medicine Update (May 16, 2020)

Introduction:

Recent research has unveiled a surprising connection between Vitamin D levels and the severity of respiratory infections, including COVID-19. Investigating the varying COVID-19 mortality rates, scientists discovered that countries with higher mortality had lower Vitamin D levels in their populations. This article explores the role of Vitamin D in COVID-19 severity, its impact on the immune system, vulnerable populations, and actionable steps individuals can take to optimize their Vitamin D levels, potentially reducing the risk of severe COVID-19 complications.

Vitamin D – A Potential Game-Changer in the Fight Against COVID-19

In our pursuit of understanding and combating COVID-19, science has uncovered a potentially significant player in the battle – Vitamin D. Recent studies, highlighted in the Lifestyle Medicine Updates, have illuminated a surprising link between Vitamin D levels and the severity of respiratory tract infections, including COVID-19 [1].

The Discovery That Turned Heads

The journey into this newfound territory began in April 2020 when a team of researchers, led by Vadim Backman at Northwestern University, embarked on a mission to decipher the factors behind the varying COVID-19 mortality rates across countries. Italy, Spain, and the UK had alarmingly high rates compared to countries with milder impacts. The team was determined to unravel this mystery.

The Role of Vitamin D in COVID-19 Severity

As the research progressed, a striking pattern emerged. Patients from countries with elevated COVID-19 mortality rates, like Italy and Spain, had lower levels of Vitamin D compared to those from less severely affected regions. The connection was undeniable, and it led the researchers down an unexpected path – a significant correlation with Vitamin D deficiency [1].

Vadim Backman explained that despite hypotheses suggesting factors like healthcare quality, population age distribution, testing rates, or different coronavirus strains, none appeared to be the primary culprit. Instead, Vitamin D deficiency stood out as a prominent factor influencing the severity of COVID-19 outcomes [3].

Unravelling the Mechanism – How Vitamin D Impacts COVID-19

Understanding the connection between Vitamin D and COVID-19 severity requires delving into the intricate workings of our immune system.

    • The Immune System’s Dual Role: Our immune system comprises two branches: the innate and adaptive immune systems. Vitamin D plays a pivotal role in both.
    • Innate Immune System:  This frontline defence relies on Vitamin D to synthesize anti-septic chemicals that act like molecular warriors, combating viruses, bacteria, and fungi on contact. Adequate Vitamin D levels equip this system to swiftly neutralize pathogens, preventing infections from taking root.
    • Adaptive Immune System: If an infection does gain a foothold, the adaptive immune system steps in, generating specific antibodies to combat the invader. However, sometimes, this system can overreact, releasing excessive cytokines – small proteins responsible for cell signalling. This overreaction can trigger a cytokine storm, leading to organ failure and often, death.
    • The Role of Vitamin D Deficiency

      • Low levels of Vitamin D not only hinder the innate immune system’s ability to counteract pathogens but also contribute to the overactivation of the adaptive immune system. This overactivity results in the dreaded cytokine storm, responsible for the life-threatening aspects of the virus. In essence, it’s not the virus itself but the immune system’s response that poses the greatest danger.

      Optimal Vitamin D levels enhance the innate immune system’s effectiveness in eradicating viruses upon contact and temper the adaptive immune system’s response. This balance allows the body to generate necessary antibodies to combat the infection without spiralling into a cytokine storm.

      Interestingly, children, who are less prone to cytokine storms, have not fully developed their adaptive immune systems, potentially explaining why they are largely spared from the severe effects of COVID-19 [1].

    The Vulnerable Populations

    Certain groups are more susceptible to Vitamin D deficiency, making them particularly vulnerable during the COVID-19 pandemic.

    • Elderly Individuals: Those over 80 years old often fall into the high-risk category for Vitamin D deficiency, prevalent in many developed countries.
    •  Darker-Skinned Individuals: People with darker skin living above or below the 40th-degree latitude in developed countries are at risk of year-round Vitamin D deficiency. The higher melanin levels in their skin function as a shield against UV light, preventing Vitamin D synthesis.
    •  Overweight Individuals: Obesity, a known risk factor for severe COVID-19 outcomes, is linked to low Vitamin D levels. Excess body fat stores more Vitamin D, reducing its circulation in the bloodstream. Overweight individuals also release inflammatory cytokines from fat cells, further lowering Vitamin D levels.

    Actionable Steps – Assessing and Addressing Vitamin D Levels

    In light of these findings, it is prudent for individuals to consider assessing and optimizing their Vitamin D levels, especially during the ongoing pandemic.

    • The Importance of Assessment: A crucial first step is to have your Vitamin D levels assessed by a healthcare provider. If your blood Vitamin D level falls below 80 nmol/L (32 ng/ml), it may be wise to discuss a strategy for achieving an ideal or optimal range.
    • Sunlight and Supplements: Sunlight is a natural source of Vitamin D, but for those living in regions where sunlight is limited, especially during the winter months, supplementation may be necessary. A healthcare professional can guide you in determining the right dosage for your individual needs.
    • The Insights of Researchers: Experts like Vadim Backman, who have closely examined the link between Vitamin D and COVID-19, emphasize the potential benefits of optimizing Vitamin D levels. Their research suggests that not only can Vitamin D promote bone and muscle health, but it may also reduce the severity of COVID-19 complications by regulating and suppressing the inflammatory cytokine response [3].

    A Brighter Horizon with Vitamin D

    As we navigate the complexities of the COVID-19 pandemic, the role of Vitamin D shines as a potential ally in our quest for better health outcomes. This unassuming vitamin, often associated with bone health, may hold the key to mitigating the severe consequences of the virus.

    While further research is needed to fully understand the intricacies of COVID-19 and other coronaviruses, the evidence so far suggests that optimizing Vitamin D levels could be a wise step in protecting our health. In the face of uncertainty, let us embrace the power of knowledge and work towards a brighter and healthier future.

    References:

    1. Ali Daneshkhah, Vasundhara Agrawal, Adam Eshein, Hariharan Subramanian, Hemant Kumar Roy, Vadim Backman. The Possible Role of Vitamin D in Suppressing Cytokine Storm and Associated Mortality in COVID-19 Patients. medRxiv, Posted April 30, 2020 [Link](https://www.medrxiv.org/content/10.1101/2020.04.08.20058578v3)
    2. “Cytokine Storm and Covid-19” – The Lancet, April 27, 2020 [Link](https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(20)30216-2/fulltext)
    3. Quotes from the Lead Researcher Vadim Backman [Link](https://www.sciencedaily.com/releases/2020/05/200507121353.htm)
    4. Laird E, Rhodes J, Kenny RA. Vitamin D and inflammation: Potential implications for the severity of Covid-19. Irish Medical Journal. 113;5:81 2020. [Link](http://imj.ie/vitamin-d-and-inflammation-potential-implications-for-severity-of-covid-19/)
    5. “Vitamin D levels appear to play role in COVID-19 mortality rates” – Science Daily, May 12, 2020 [Link](https://www.sciencedaily.com/releases/2020/05/200512134426.htm)

Eat Smart, Live Well, Look Great,

Dr. Meschino

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 161 – Unlocking the Power of Vitamin D: A Shield Against Respiratory Infections

LMU-161

LMU 161 – Unlocking the Power of Vitamin D: A Shield Against Respiratory Infections

Source: PLOS journal June 2013

Lifestyle Medicine Update (May 2, 2020)

Introduction:

Vitamin D is a vital player in immune health, influencing our body’s ability to fend off respiratory tract infections. However, maintaining the right balance is key, as both low and excessively high vitamin D levels pose risks. This delicate equilibrium can impact our immune response. In this discussion, we explore how optimizing vitamin D levels can enhance immunity and prevent respiratory infections, providing insights into the importance of maintaining this essential nutrient at the right levels.

The Vitamin D Revolution in Respiratory Health

In the battle against respiratory tract infections, science has uncovered a potent ally: Vitamin D. A groundbreaking review article, “Vitamin D and Respiratory Tract Infections,” published in 2013 by Bergman et al., sheds light on the profound impact of this humble vitamin on our immune system’s ability to fend off invaders [1].

The Critical Connection Between Vitamin D and Immunity

The review encompassed data from eleven placebo-controlled studies, involving a total of 5,660 patients. What emerged from this meticulous analysis were revelations that could reshape our approach to preventing respiratory infections.

  • Optimal Levels for Immunity

    • One of the central findings of the review is the importance of maintaining optimal vitamin D blood levels. Individuals with vitamin D levels below 75 nmol/L (30 ng/ml) were found to be at a higher risk of respiratory tract infections. This observation aligns with the crucial role vitamin D plays in our immune system.

    Vitamin D acts as a catalyst for immune cells lining the respiratory tract, enabling them to synthesize molecules that act like molecular daggers. These molecules puncture viruses and bacteria, swiftly neutralizing them before an infection takes hold.

  • The Double-Edged Sword of Vitamin D

    • Surprisingly, the study also illuminated a paradoxical aspect of vitamin D. While too little can leave us vulnerable, too much can be detrimental. Individuals with vitamin D levels soaring above 140 nmol/L (56 ng/ml) were found to have an increased susceptibility to respiratory infections. This paradox can be attributed to vitamin D’s impact on the release of certain cytokines, key players in the adaptive immune system’s response.

    In autoimmune conditions like Multiple Sclerosis, high doses of vitamin D have shown promise. They help modulate the overactive behavior of T and B-lymphocytes, which are notorious for exacerbating inflammation and demyelination in the disease. This modulation can induce remission or sustain it, offering hope to those affected.

Vitamin D Deficiency – A Widespread Problem

In light of these findings, the prevalence of sub-optimal vitamin D levels in society becomes a pressing concern. A significant portion of the population falls below the 75 nmol/L (30 ng/ml) threshold. This deficiency, it seems, could be a silent contributor to the burden of respiratory infections.

  • The Call for Supplementation

    • The implications are clear: for many, vitamin D supplementation could be a game-changer. Elevating vitamin D levels above the 75 nmol/L mark appears to confer a significant reduction in the risk of respiratory tract infections. This approach can be especially beneficial in the winter months when sunlight, a natural source of vitamin D, is scarce.

  • Caution in Mega-Dosing

    • However, a word of caution is warranted. Mega-dosing with vitamin D, defined here as daily doses ranging from 5,000 to 20,000 IU, can push vitamin D levels to excess, increasing the risk of respiratory infections. It is essential to strike a balance.

Timing Matters – Daily vs. Intermittent Supplementation

Moreover, the timing and frequency of supplementation play a vital role. Daily doses of vitamin D, such as 1,000 to 3,000 IU, have proven to be significantly more effective at enhancing immune function than infrequent, high-dose regimens, such as weekly, monthly, or every three months. In fact, a sudden influx of vitamin D into the body can actually dampen immune responses.

  • Tailoring Vitamin D Intake

    • The takeaway message is clear: individualized vitamin D intake is key. Understanding your baseline vitamin D level is crucial. If it falls below the 75 nmol/L (30 ng/ml) threshold, consult your healthcare provider about an appropriate daily supplement regimen.

    Conversely, if your vitamin D levels have scaled the 140 nmol/L (56 ng/ml) peak, it may be wise to reassess your supplementation strategy, unless your specialist has prescribed this as part of managing an autoimmune condition.

  • Beyond Immunity – The Wider Implications of Vitamin D

    • While the focus here has been on the immune-boosting properties of vitamin D, its benefits extend far beyond respiratory health. Research continues to unveil its role in bone health, cardiovascular wellness, and even mental health.

Conclusion: A Bright Future with Vitamin D

The review article by Bergman et al. has illuminated the pivotal role of vitamin D in respiratory health. It has provided a roadmap for individuals to fortify their immune systems and reduce the risk of respiratory tract infections.

However, this journey is not without its pitfalls. Balance is key, and understanding one’s own vitamin D levels is the compass guiding us to that equilibrium.

So, as we move forward, let us take heed of this research and embrace the power of vitamin D, not as a mere supplement but as a shield against the invisible invaders that threaten our respiratory well-being.

References:

  1. Bergman P, Lindh A, Bjorkhem-Bergman, Lindh J. Vitamin D and respiratory tract infections: A systemic review and meta-analysis of randomized controlled studies. *PLOS (peer-reviewed, open-access journal).* 2013; 8(6):e65835 [Link](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3686844
 

Eat Smart, Live Well, Look Great,

Dr. Meschino

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

Adeeva Supplements
Posted on by

LMU 139 – Harnessing Vitamin C for Immune Power: Unveiling the Dynamic Link

LMU-139

LMU 139 – Harnessing Vitamin C for Immune Power: Unveiling the Dynamic Link

Source: Journal “Nutrients” (Nov 2017)

Lifestyle Medicine Update (August 17, 2019)

Introduction:

Embark on a journey that delves deep into the realms of human health and immunity, guided by the beacon of vitamin C. Our tale begins with a fascinating review nestled within the pages of the “Nutrients” journal, published in November 2017. Prepare to unravel the remarkable connection between vitamin C, immune strength, and the intricate dance of health and deficiency.

Vitamin C: A Deficiency Lurking

A revelation surfaces—vitamin C deficiency, a silent adversary, ranks as the fourth most prevalent nutrient insufficiency in the United States. A threshold, quantified at 11 micromoles per liter (11umol/L), demarcates the realm of deficiency. Widespread causes emerge—a palette of poor dietary choices, coupled with our body’s limited reservoir for storing vitamin C. A symphony of factors elevates the stakes—air pollution, smoking, second-hand smoke, alcohol, and even stress. The need for vitamin C heightens when battling infections, weathering stress, and confronting diseases laced with oxidative and inflammatory traits.

Vitamin C: A Shield for Immunity

Immune cells, sentinels of defence, harbor an insatiable appetite for vitamin C. These guardians, particularly neutrophils, hoard vitamin C at levels 50-100 times beyond the bloodstream’s store. In this dance of defence, the narrative unfolds—adequate vitamin C is the key. The journey towards immune strength traverses paths of migration to infection sites, the orchestration of microbe destruction, and the containment of inflammation. The script unfurls—vitamin C arms immune cells with the tools to navigate, annihilate, and restore order amidst the battleground of infections.

Pinnacle of Health: Vitamin C Supplementation

Studies weave a tapestry of insights, whispering the magic of 250 mg daily vitamin C intake in bolstering immune prowess. The crescendo echoes—attaining a blood level exceeding fifty umol/L becomes the hallmark of success, attainable with 100-250 mg daily. Yet, this symphony presents a paradox—food alone struggles to weave this tale, beckoning vitamin C supplementation into the limelight. The years write a new verse—with age, immunity falters, beckoning higher doses. A potion of 1,000 mg vitamin C alongside 200 IU of vitamin E becomes the elixir for those treading beyond sixty.

Battling the Common Cold: A Healing Tale

A chapter unfolds, chronicling the battle against the common cold. The pages divulge a remedy—200 mg daily vitamin C, reducing the cold’s severity and duration. A twist in the tale surfaces—the common cold’s frequency bows before the might of vitamin C when blood levels dipped below 45 umol/L. A revelation stands—the surge to 1,000 mg daily guards against the erosion of vitamin C within immune cells during infection.

Vitamin C and Healing: A Saga Unveiled

Lungs echo a tale—pneumonia, lung infections, and healing find a companion in vitamin C. In the corridors of research, a voice emerges, echoing the impact. A study’s essence encapsulated—vitamin C, a savior for pneumonia’s severity. The narrative deepens—500-1600 mg daily steers a 36% reduction in hospital stay, a symphony of recovery orchestrated by vitamin C’s touch.

Immunity and Allergies: A Dance Unveiled

Histamine, the orchestrator of allergies, takes center stage. Vitamin C emerges—a beacon of hope for allergic souls. A range of 125-2,000 mg daily quells histamine’s surge, soothing allergic turmoil. The crescendo peaks—an infusion of 7,500 mg embarks on a transformative journey, quelling histamine’s storm within immune cells—eosinophils, basophils, and mast cells.

Type 2 Diabetes and Beyond: A Chronicle of Healing

Type 2 diabetes unveils its nexus with vitamin C—a dance of suppressed inflammation, balanced blood sugar, and renewed healing. The script inscribed—500 mg twice daily, a symphony to mend not just blood sugar, but also immunity.

Epilogue: Weaving Immunity’s Tapestry

As we conclude this voyage, a tapestry of wisdom adorns our path. Immunity’s guardian, vitamin C, threads through our tale, its impact echoing through studies and revelations. An ode to health and longevity, a chorus that weaves a life enriched by immune strength, stands as the testament of our choices. Yet, wisdom whispers—consult your guide, your physician, as the path towards health weaves through a nuanced landscape.

References:

Carr A and Maggin S. Vitamin C and immune function. Nutrients. 2017 Nov.9(11):1211 [Link](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707683/)


Eat Smart, Live Well, Look Great,

Dr. James Meschino

Introduction:

Embark on a journey that delves deep into the realms of human health and immunity, guided by the beacon of vitamin C. Our tale begins with a fascinating review nestled within the pages of the “Nutrients” journal, published in November 2017. Prepare to unravel the remarkable connection between vitamin C, immune strength, and the intricate dance of health and deficiency.

Vitamin C: A Deficiency Lurking

A revelation surfaces—vitamin C deficiency, a silent adversary, ranks as the fourth most prevalent nutrient insufficiency in the United States. A threshold, quantified at 11 micromoles per liter (11umol/L), demarcates the realm of deficiency. Widespread causes emerge—a palette of poor dietary choices, coupled with our body’s limited reservoir for storing vitamin C. A symphony of factors elevates the stakes—air pollution, smoking, second-hand smoke, alcohol, and even stress. The need for vitamin C heightens when battling infections, weathering stress, and confronting diseases laced with oxidative and inflammatory traits.

Vitamin C: A Shield for Immunity

Immune cells, sentinels of defence, harbor an insatiable appetite for vitamin C. These guardians, particularly neutrophils, hoard vitamin C at levels 50-100 times beyond the bloodstream’s store. In this dance of defence, the narrative unfolds—adequate vitamin C is the key. The journey towards immune strength traverses paths of migration to infection sites, the orchestration of microbe destruction, and the containment of inflammation. The script unfurls—vitamin C arms immune cells with the tools to navigate, annihilate, and restore order amidst the battleground of infections.

Pinnacle of Health: Vitamin C Supplementation

Studies weave a tapestry of insights, whispering the magic of 250 mg daily vitamin C intake in bolstering immune prowess. The crescendo echoes—attaining a blood level exceeding fifty umol/L becomes the hallmark of success, attainable with 100-250 mg daily. Yet, this symphony presents a paradox—food alone struggles to weave this tale, beckoning vitamin C supplementation into the limelight. The years write a new verse—with age, immunity falters, beckoning higher doses. A potion of 1,000 mg vitamin C alongside 200 IU of vitamin E becomes the elixir for those treading beyond sixty.

Battling the Common Cold: A Healing Tale

A chapter unfolds, chronicling the battle against the common cold. The pages divulge a remedy—200 mg daily vitamin C, reducing the cold’s severity and duration. A twist in the tale surfaces—the common cold’s frequency bows before the might of vitamin C when blood levels dipped below 45 umol/L. A revelation stands—the surge to 1,000 mg daily guards against the erosion of vitamin C within immune cells during infection.

Vitamin C and Healing: A Saga Unveiled

Lungs echo a tale—pneumonia, lung infections, and healing find a companion in vitamin C. In the corridors of research, a voice emerges, echoing the impact. A study’s essence encapsulated—vitamin C, a savior for pneumonia’s severity. The narrative deepens—500-1600 mg daily steers a 36% reduction in hospital stay, a symphony of recovery orchestrated by vitamin C’s touch.

Immunity and Allergies: A Dance Unveiled

Histamine, the orchestrator of allergies, takes center stage. Vitamin C emerges—a beacon of hope for allergic souls. A range of 125-2,000 mg daily quells histamine’s surge, soothing allergic turmoil. The crescendo peaks—an infusion of 7,500 mg embarks on a transformative journey, quelling histamine’s storm within immune cells—eosinophils, basophils, and mast cells.

Type 2 Diabetes and Beyond: A Chronicle of Healing

Type 2 diabetes unveils its nexus with vitamin C—a dance of suppressed inflammation, balanced blood sugar, and renewed healing. The script inscribed—500 mg twice daily, a symphony to mend not just blood sugar, but also immunity.

Epilogue: Weaving Immunity’s Tapestry

As we conclude this voyage, a tapestry of wisdom adorns our path. Immunity’s guardian, vitamin C, threads through our tale, its impact echoing through studies and revelations. An ode to health and longevity, a chorus that weaves a life enriched by immune strength, stands as the testament of our choices. Yet, wisdom whispers—consult your guide, your physician, as the path towards health weaves through a nuanced landscape.

References:

Carr A and Maggin S. Vitamin C and immune function. Nutrients. 2017 Nov.9(11):1211 [Link](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707683/)


Eat Smart, Live Well, Look Great,

Dr. James Meschino

Introduction:

Embark on a journey that delves deep into the realms of human health and immunity, guided by the beacon of vitamin C. Our tale begins with a fascinating review nestled within the pages of the “Nutrients” journal, published in November 2017. Prepare to unravel the remarkable connection between vitamin C, immune strength, and the intricate dance of health and deficiency.

Vitamin C: A Deficiency Lurking

A revelation surfaces—vitamin C deficiency, a silent adversary, ranks as the fourth most prevalent nutrient insufficiency in the United States. A threshold, quantified at 11 micromoles per liter (11umol/L), demarcates the realm of deficiency. Widespread causes emerge—a palette of poor dietary choices, coupled with our body’s limited reservoir for storing vitamin C. A symphony of factors elevates the stakes—air pollution, smoking, second-hand smoke, alcohol, and even stress. The need for vitamin C heightens when battling infections, weathering stress, and confronting diseases laced with oxidative and inflammatory traits.

Vitamin C: A Shield for Immunity

Immune cells, sentinels of defence, harbor an insatiable appetite for vitamin C. These guardians, particularly neutrophils, hoard vitamin C at levels 50-100 times beyond the bloodstream’s store. In this dance of defence, the narrative unfolds—adequate vitamin C is the key. The journey towards immune strength traverses paths of migration to infection sites, the orchestration of microbe destruction, and the containment of inflammation. The script unfurls—vitamin C arms immune cells with the tools to navigate, annihilate, and restore order amidst the battleground of infections.

Pinnacle of Health: Vitamin C Supplementation

Studies weave a tapestry of insights, whispering the magic of 250 mg daily vitamin C intake in bolstering immune prowess. The crescendo echoes—attaining a blood level exceeding fifty umol/L becomes the hallmark of success, attainable with 100-250 mg daily. Yet, this symphony presents a paradox—food alone struggles to weave this tale, beckoning vitamin C supplementation into the limelight. The years write a new verse—with age, immunity falters, beckoning higher doses. A potion of 1,000 mg vitamin C alongside 200 IU of vitamin E becomes the elixir for those treading beyond sixty.

Battling the Common Cold: A Healing Tale

A chapter unfolds, chronicling the battle against the common cold. The pages divulge a remedy—200 mg daily vitamin C, reducing the cold’s severity and duration. A twist in the tale surfaces—the common cold’s frequency bows before the might of vitamin C when blood levels dipped below 45 umol/L. A revelation stands—the surge to 1,000 mg daily guards against the erosion of vitamin C within immune cells during infection.

Vitamin C and Healing: A Saga Unveiled

Lungs echo a tale—pneumonia, lung infections, and healing find a companion in vitamin C. In the corridors of research, a voice emerges, echoing the impact. A study’s essence encapsulated—vitamin C, a savior for pneumonia’s severity. The narrative deepens—500-1600 mg daily steers a 36% reduction in hospital stay, a symphony of recovery orchestrated by vitamin C’s touch.

Immunity and Allergies: A Dance Unveiled

Histamine, the orchestrator of allergies, takes center stage. Vitamin C emerges—a beacon of hope for allergic souls. A range of 125-2,000 mg daily quells histamine’s surge, soothing allergic turmoil. The crescendo peaks—an infusion of 7,500 mg embarks on a transformative journey, quelling histamine’s storm within immune cells—eosinophils, basophils, and mast cells.

Type 2 Diabetes and Beyond: A Chronicle of Healing

Type 2 diabetes unveils its nexus with vitamin C—a dance of suppressed inflammation, balanced blood sugar, and renewed healing. The script inscribed—500 mg twice daily, a symphony to mend not just blood sugar, but also immunity.

Epilogue: Weaving Immunity’s Tapestry

As we conclude this voyage, a tapestry of wisdom adorns our path. Immunity’s guardian, vitamin C, threads through our tale, its impact echoing through studies and revelations. An ode to health and longevity, a chorus that weaves a life enriched by immune strength, stands as the testament of our choices. Yet, wisdom whispers—consult your guide, your physician, as the path towards health weaves through a nuanced landscape.

References:

Carr A and Maggin S. Vitamin C and immune function. Nutrients. 2017 Nov.9(11):1211 [Link](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707683/)

Eat Smart, Live Well, Look Great,

Dr. James Meschino

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

Adeeva Supplements
Posted on by

LMU 132 – Unveiling the Immune Modulator: Vitamin D’s Role in Autoimmune Health

LMU-132

LMU 132 – Unveiling the Immune Modulator: Vitamin D's Role in Autoimmune Health

Source: Frontiers in Immunology (March 2019)

Lifestyle Medicine Update (June 15, 2019)

Introduction:

The intricate dance of the human immune system is a delicate balance that safeguards the body against invaders while preserving its own tissues. However, for around 6% of the population plagued by autoimmune diseases, this balance falters, leading to the immune system’s misdirected assault on its own cells. The emergence of new drugs in recent years has transformed the management of these conditions, but there’s an unexpected addition to the arsenal—vitamin D supplementation. In the evolving landscape of autoimmune health, vitamin D has emerged as a potential game-changer, with mounting evidence of its pivotal role in taming the immune response.

Autoimmune Ailments: The Battle Within

Autoimmune diseases cast a shadow over the lives of millions, as the immune system turns traitor, attacking normal tissues instead of defending them. From lupus to rheumatoid arthritis, these conditions can disrupt lives and health. In a bid to alleviate the burden, researchers and healthcare professionals have been exploring novel strategies, leading to the development of new drugs that tackle autoimmune conditions head-on. Amid these advancements, an unexpected contender has taken center stage—vitamin D.

Vitamin D’s Immune Influence: Unveiling the Mechanism

In recent years, the scientific community has uncovered a hitherto unforeseen facet of vitamin D’s role—it wields a direct impact on a specific type of immune cell known as dendritic cells. These cells are key instigators in the autoimmune process when they deviate from their intended path. Vitamin D, it seems, can step in as a regulator, influencing dendritic cells’ behavior. Research has highlighted the vitamin’s ability to inhibit the production and expression of co-stimulatory molecules and specific receptors on dendritic cells, molecules that fan the flames of inflammation, a hallmark of autoimmune diseases. By restraining these inflammation-propelling elements, vitamin D exerts a calming influence on the autoimmune cascade.

A New Chapter: Vitamin D and CD31 Adhesion Molecule

The narrative takes an intriguing turn in the March issue of the journal Frontiers in Immunology, where researchers unveil another layer of vitamin D’s immune-modulating prowess. Their study unveils a previously unknown role—encouraging dendritic cells to exhibit a molecule on their surface, known as the CD31 adhesion molecule. This molecule serves as a direct messenger of anti-inflammation to another key player in the immune symphony—the CD4 cell. In the tumult of autoimmune disease, dendritic cells and their counterparts orchestrate the transformation of CD4 cells into aggressive warriors that unleash torrents of inflammatory substances, triggering a domino effect of immune turmoil. By fostering the expression of CD31 molecules on dendritic cells’ surfaces, vitamin D indirectly communicates with CD4 cells, hindering them from rallying the immune troops against the body’s own tissues. CD31 assumes the role of an inhibitory messenger, curbing the inflammatory chorus that characterizes autoimmune conditions.

Clinical Wisdom: The Role of Rheumatologists

In the field of rheumatology, where autoimmune diseases hold sway, healthcare professionals are embracing the potential of vitamin D as a complementary tool. It’s not uncommon for rheumatologists to incorporate vitamin D supplementation into their treatment regimens. The rationale is clear—vitamin D’s multifaceted influence on the immune response resonates with the complex tapestry of autoimmune conditions. While a general guideline of 2,000 IU of vitamin D per day is often recommended, personalized approaches are gaining traction. Tailoring dosages based on the specific autoimmune disease and individual vitamin D levels optimizes the potential benefits.

From Prevention to Intervention: Vitamin D’s Spectrum

The connection between vitamin D levels and autoimmune risk is a subject of growing interest. Low vitamin D levels are closely associated with heightened susceptibility to autoimmune diseases. For those aiming at prevention, maintaining vitamin D blood levels within the range of 80 to 150 nmol/L (32 – 60 ng/ml) could be a strategic step. As the pieces of the puzzle fall into place, it’s becoming evident that vitamin D’s impact extends beyond immune modulation—it’s a guardian of autoimmune health.

Conclusion: A Promising Path Forward

As science delves deeper into the intricate nuances of the immune system, the role of vitamin D becomes ever more captivating. Its influence on dendritic cells and CD4 cells paints a vivid picture of immune orchestration. While vitamin D is not a panacea, it’s undoubtedly a piece of the puzzle in the realm of autoimmune health. As healthcare professionals fine-tune treatment plans and individuals strive for proactive wellness, vitamin D emerges as a potential ally, offering hope and new avenues in the fight against autoimmune diseases.

References:

Louise Saul, Iris Mair, Alasdair Ivens, Pamela Brown, Kay Samuel, John D. M. Campbell, Daniel Y. Soong, Nadine Kamenjarin, Richard J. Mellanby. 1,25- dihydroxyvitamin D3 Restrains CD4 T Cell Priming Ability of CD11c Dendritic Cells by Upregulating Expression of CD31. Frontiers in Immunology, 2019; 10.3389/fimmu.2019.00600


Eat Smart, Live Well, Look Great

Dr. Meschino

Introduction:

The intricate dance of the human immune system is a delicate balance that safeguards the body against invaders while preserving its own tissues. However, for around 6% of the population plagued by autoimmune diseases, this balance falters, leading to the immune system’s misdirected assault on its own cells. The emergence of new drugs in recent years has transformed the management of these conditions, but there’s an unexpected addition to the arsenal—vitamin D supplementation. In the evolving landscape of autoimmune health, vitamin D has emerged as a potential game-changer, with mounting evidence of its pivotal role in taming the immune response.

Autoimmune Ailments: The Battle Within

Autoimmune diseases cast a shadow over the lives of millions, as the immune system turns traitor, attacking normal tissues instead of defending them. From lupus to rheumatoid arthritis, these conditions can disrupt lives and health. In a bid to alleviate the burden, researchers and healthcare professionals have been exploring novel strategies, leading to the development of new drugs that tackle autoimmune conditions head-on. Amid these advancements, an unexpected contender has taken center stage—vitamin D.

Vitamin D’s Immune Influence: Unveiling the Mechanism

In recent years, the scientific community has uncovered a hitherto unforeseen facet of vitamin D’s role—it wields a direct impact on a specific type of immune cell known as dendritic cells. These cells are key instigators in the autoimmune process when they deviate from their intended path. Vitamin D, it seems, can step in as a regulator, influencing dendritic cells’ behavior. Research has highlighted the vitamin’s ability to inhibit the production and expression of co-stimulatory molecules and specific receptors on dendritic cells, molecules that fan the flames of inflammation, a hallmark of autoimmune diseases. By restraining these inflammation-propelling elements, vitamin D exerts a calming influence on the autoimmune cascade.

A New Chapter: Vitamin D and CD31 Adhesion Molecule

The narrative takes an intriguing turn in the March issue of the journal Frontiers in Immunology, where researchers unveil another layer of vitamin D’s immune-modulating prowess. Their study unveils a previously unknown role—encouraging dendritic cells to exhibit a molecule on their surface, known as the CD31 adhesion molecule. This molecule serves as a direct messenger of anti-inflammation to another key player in the immune symphony—the CD4 cell. In the tumult of autoimmune disease, dendritic cells and their counterparts orchestrate the transformation of CD4 cells into aggressive warriors that unleash torrents of inflammatory substances, triggering a domino effect of immune turmoil. By fostering the expression of CD31 molecules on dendritic cells’ surfaces, vitamin D indirectly communicates with CD4 cells, hindering them from rallying the immune troops against the body’s own tissues. CD31 assumes the role of an inhibitory messenger, curbing the inflammatory chorus that characterizes autoimmune conditions.

Clinical Wisdom: The Role of Rheumatologists

In the field of rheumatology, where autoimmune diseases hold sway, healthcare professionals are embracing the potential of vitamin D as a complementary tool. It’s not uncommon for rheumatologists to incorporate vitamin D supplementation into their treatment regimens. The rationale is clear—vitamin D’s multifaceted influence on the immune response resonates with the complex tapestry of autoimmune conditions. While a general guideline of 2,000 IU of vitamin D per day is often recommended, personalized approaches are gaining traction. Tailoring dosages based on the specific autoimmune disease and individual vitamin D levels optimizes the potential benefits.

From Prevention to Intervention: Vitamin D’s Spectrum

The connection between vitamin D levels and autoimmune risk is a subject of growing interest. Low vitamin D levels are closely associated with heightened susceptibility to autoimmune diseases. For those aiming at prevention, maintaining vitamin D blood levels within the range of 80 to 150 nmol/L (32 – 60 ng/ml) could be a strategic step. As the pieces of the puzzle fall into place, it’s becoming evident that vitamin D’s impact extends beyond immune modulation—it’s a guardian of autoimmune health.

Conclusion: A Promising Path Forward

As science delves deeper into the intricate nuances of the immune system, the role of vitamin D becomes ever more captivating. Its influence on dendritic cells and CD4 cells paints a vivid picture of immune orchestration. While vitamin D is not a panacea, it’s undoubtedly a piece of the puzzle in the realm of autoimmune health. As healthcare professionals fine-tune treatment plans and individuals strive for proactive wellness, vitamin D emerges as a potential ally, offering hope and new avenues in the fight against autoimmune diseases.

References:

Louise Saul, Iris Mair, Alasdair Ivens, Pamela Brown, Kay Samuel, John D. M. Campbell, Daniel Y. Soong, Nadine Kamenjarin, Richard J. Mellanby. 1,25- dihydroxyvitamin D3 Restrains CD4 T Cell Priming Ability of CD11c Dendritic Cells by Upregulating Expression of CD31. Frontiers in Immunology, 2019; 10.3389/fimmu.2019.00600

Eat Smart, Live Well, Look Great

Dr. Meschino

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

Adeeva Supplements
Posted on by

LMU 111 – Unveiling the Cardiovascular Benefits of Vitamin D: A Key to High Blood Pressure Prevention and Stroke Recovery

LMU-111

LMU 111 – Unveiling the Cardiovascular Benefits of Vitamin D: A Key to High Blood Pressure Prevention and Stroke Recovery

Source: International Journal of Nanomedicine (January 2018)

Lifestyle Medicine Update (November 3, 2018)

Introduction

In the pursuit of optimal health, understanding the intricate links between nutrition, physiology, and disease prevention is paramount. One such nexus lies in the relationship between vitamin D and cardiovascular well-being. A wealth of research has highlighted the intriguing connection between higher blood vitamin D levels and a reduced risk of high blood pressure (hypertension), enhanced heart function, and improved cardiorespiratory fitness. This article delves into the scientific studies that underscore the importance of vitamin D in guarding against high blood pressure and stroke, as well as elucidates the mechanisms through which this essential nutrient contributes to cardiovascular vitality.

The Foundations: Studies Supporting Vitamin D’s Cardiovascular Benefits

The cornerstone of this discourse rests on an illuminating study published in the International Journal of Nanomedicine in January 2018[^1^]. This research serves as a lighthouse guiding us through the intricate pathways by which vitamin D influences our cardiovascular health. But before delving into the specifics of this study, it is crucial to acknowledge the complementary insights provided by prior investigations. Notably, a 2017 study featured in the Journal of Clinical Diagnostic Research[^2^] corroborated the notion that lower vitamin D levels correlate with an increased risk of stroke. Moreover, administering vitamin D to stroke patients within the initial days post-stroke yielded remarkable outcomes—improved functional results at the three-month mark, coupled with reduced mortality and disabilities.

Vitamin D’s Role in Cardiovascular Fitness

Peering into the heart of the matter, the 2018 study[^1^] elucidated how vitamin D acts as a protector of cardiovascular health. Central to this defence mechanism is the action of vitamin D in enhancing the release of nitric oxide from the endothelial cells lining blood vessels. Nitric oxide is a vital molecule responsible for vasodilation—the widening of blood vessels—facilitating smoother blood flow and, consequently, reducing the resistance encountered by blood coursing through arteries. By lowering this resistance, vitamin D aids in maintaining diastolic blood pressure at optimal levels, thwarting its elevation.

Furthermore, the beneficial effects extend to the heart’s workload. When blood vessels dilate, the heart encounters less resistance while pumping blood through the circulatory system. This translates to a more efficient cardiovascular system and contributes to preventing an increase in systolic blood pressure. Intriguingly, this expanded arterial dilation augments the delivery of oxygen and nutrients to muscles during exercise, elucidating the superior cardiorespiratory fitness observed in individuals with higher blood vitamin D levels.

Empirical Evidences and Associations

Numerous empirical studies have illuminated the associations between blood vitamin D levels and cardiovascular health. Notably, analyses of extensive datasets such as the National Health and Nutrition Examination Surveys have unveiled that blood vitamin D levels exceeding 32.4 ng/ml (81 nmol/L) exhibit a robust correlation with a diminished risk of high blood pressure[^2^]. These findings have been fortified through meticulous control for confounding factors—age, sex, race, smoking, alcohol consumption, body mass index (BMI), physical activity, diabetes, cholesterol levels, C-reactive protein, kidney function, and more—solidifying the link between higher vitamin D levels and cardiovascular fortitude.

Unveiling the Mechanisms: Nitric Oxide and Beyond

The 2018 study[^1^] offers a pivotal insight into the mechanisms underlying vitamin D’s cardiovascular effects. It postulates that vitamin D plays a pivotal role in stimulating the release of nitric oxide from endothelial cells, thus fostering vasodilation. This cascading effect translates to an open expressway for blood, mitigating resistance and averting the rise of blood pressure. This proposition underscores the importance of evaluating one’s blood vitamin D levels, with a recommended target of 30 ng/ml or 80 nmol/L. However, a cautious approach is advised to prevent vitamin D toxicity, necessitating levels to remain below 100 ng/ml or 250 nmol/L.

Future Implications and Concluding Thoughts

As the body of research linking vitamin D to cardiovascular health continues to expand, the importance of sustaining optimal vitamin D levels gains prominence. The profound impact of this nutrient on blood pressure regulation, stroke recovery, and cardiorespiratory fitness heralds a new era in preventive medicine. Individuals are encouraged to collaborate with healthcare professionals to ensure their vitamin D status aligns with recommended thresholds, fostering a robust cardiovascular foundation. With its multifaceted benefits, vitamin D emerges as a potent ally in the quest for a heart-healthy life.

References:

  1. Khan A, Dawoud H, Malinski T. Nanomedical studies of the restoration of nitric oxide/peroxynitrite balance in the dysfunctional endothelium by 1,25-dihydroxy vitamin D3- clinical implications for cardiovascular disease. International Journal of Nanomedicine. 2018;13: 455-466. [Read the study here](https://www.dovepress.com/nanomedical-studies-of-the-restoration-of-nitric-oxideperoxynitrite-ba-peer-reviewed-article-IJN)
  2. [Vitamin D may help fight high blood pressure. Medical News Today.](https://www.medicalnewstoday.com/articles/320802.php)
  3. [Vitamin D and Stroke: Implications in Cardiovascular Risk. National Library of Medicine.](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376887/)
  4. [Vitamin D and Higher Cardiorespiratory Fitness: Unveiling the Link. Sage Journals.](http://journals.sagepub.com/doi/10.1177/2047487318807279)
  5. 5. [The Link Between Prehypertension and Low Vitamin D Levels. Healio Endocrinology.](https://www.healio.com/endocrinology/news/online/%7B765aa8d6-1144-4dba-b1fc-3b92a1e186f4%7D/prehypertension-linked-to-low-vitamin-d?utm_source=TrendMD&utm_medium=cpc&utm_campaign=Healio__TrendMD_1)

Eat Smart, Live Well, Look Great,


Dr. Meschino

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 94 – Sunshine Vitamin Shields Against Colorectal Cancer: The Vitamin D Revelation

LMU-94

LMU 94 – Sunshine Vitamin Shields Against Colorectal Cancer: The Vitamin D Revelation

Source: Journal of the National Cancer Institute (2018)

Lifestyle Medicine Update (July 7, 2018)

Introduction

Colorectal cancer, the third leading cause of cancer-related deaths in North America and many developed nations, casts a shadow over countless lives. However, the tides are turning as groundbreaking research delves into the protective potential of a humble nutrient: vitamin D. A 2018 study published in the Journal of the National Cancer Institute has unveiled compelling evidence, propelling vitamin D into the spotlight as a formidable guardian against colorectal cancer. In this exploration, we journey through the study’s revelations, spotlighting the profound impact of optimal vitamin D levels on cancer prevention.

A Link Between Lifestyle and Colorectal Cancer

Colorectal cancer’s intricate dance with nutrition and lifestyle comes to the forefront. Beyond genetics, faulty nutrition and lifestyle factors weave the tapestry of this ailment. Inadequate physical activity, excess weight, smoking, and heavy alcohol consumption emerge as key players. A staggering 70-90% of cases could potentially be thwarted through prudent dietary and lifestyle choices.

The Vitamin D Vanguard: Illuminating the Role

Among various nutritional factors, the spotlight has long shone on vitamin D’s potential in preventing colorectal cancer. While preliminary studies hinted at the link, the quest for definitive data persisted. Enter a comprehensive 2018 study that amalgamated insights from 17 cohort studies, enrolling over 5,000 colorectal cancer cases and 7,000 controls. The amalgamation of these studies, tracking 12,000 individuals over an average follow-up of 5.5 years, unfurled a revelation. Individuals commencing with a blood vitamin D level exceeding 50-63 nmol/L (20 – 25 ng/mL) enjoyed a striking 22% reduction in colorectal cancer risk, in comparison to those falling within the same range.

Vitamin D Beyond Osteoporosis: A Colorectal Ally

Vitamin D’s reputation as an osteoporosis defender is well-known, advocating for blood levels between 50-63 nmol/L (20-25 ng/mL). However, the quest for colorectal cancer prevention demands a higher threshold. Achieving an additional 22% reduction in colorectal cancer risk calls for maintaining a year-round vitamin D level beyond this range. To this end, experts advise aiming for a blood vitamin D level of at least 85 nmol/L (34 ng/mL), with higher levels potentially beneficial for high-risk individuals.

Unveiling Vitamin D’s Anti-Cancer Arsenal

Venturing into the realm of scientific intricacies, vitamin D’s multi-faceted role in combating colorectal cancer emerges. Evident through human and experimental studies, its anti-cancer prowess encompasses various dimensions:

  1. Slowing Cell Division: Vitamin D’s hand slows the frantic pace of colon cell division, reducing genetic errors and the risk of cancerous transformation.
  2. Encouraging Cellular Death: Emerging cancer cells face an adversary in vitamin D, prompting programmed cell death or apoptosis.
  3. Nurturing Maturity: Vitamin D’s touch guides emerging cells towards full maturity, a process known as cellular differentiation, which curbs cancer susceptibility.
  4. Blocking Cancer Pathways: Vitamin D erects barriers against the Wnt pathway, a crucial player in colon cancer development.
  5. Taming Inflammation: Vitamin D’s anti-inflammatory prowess stands as a sentinel against inflammation-associated cancer risks.
  6. Strengthening Immunity: The vitamin’s supportive hand uplifts immune function, a pivotal aspect of cancer prevention.
  7. Countering Metastasis: Vitamin D reins in the synthesis of factors driving colon cancer metastasis, such as VEGF, curbing new blood vessel formation to sustain tumors.

A Clarion Call for Public Health Guidelines

The implications of the 2018 study resonate deeply, urging individuals and health agencies to reevaluate guidelines. With colorectal cancer’s menacing shadow, optimizing vitamin D levels emerges as a formidable strategy. Experts echo the call to maintain a blood vitamin D level above 63 nmol/L (25 ng/mL). Achieving this feat involves embracing nourishing practices, including consuming fish regularly, integrating vitamin D-fortified low-fat dairy products, and supplementing vitamin D. While sunlight exposure contributes, concerns about skin cancer risk make dietary and supplemental sources the preferred routes.

Conclusion

As science unravels the mysteries of cancer prevention, vitamin D emerges as a beacon of hope in the fight against colorectal cancer. The 2018 study’s findings pierce through the haze, revealing a tangible path towards safeguarding health. With an enhanced understanding of vitamin D’s profound anti-cancer effects, individuals are empowered to chart a course towards a brighter, healthier future. As public health guidelines undergo transformation, the chapter of colorectal cancer takes a turn towards hope and resilience, with vitamin D as its steadfast ally.

References

McCullough ML, Zoltick ES, Weinstein SJ, Fedirko V, Wang M et al. Circulating vitamin D and colorectal cancer risk: An international pooling project of 17 cohorts. JNCI. June 2018

[Link] (https://academic.oup.com/jnci/advance-article-abstract/doi/10.1093/jnci/djy087/5035027?redirectedFrom=fulltext)

Eat Smart, Live Well, Look Great

Dr. Meschino

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 76 – Unveiling Nutritional Deficiencies in Aging: A Closer Look at Vitamin D, B12, and More

LMU-76

LMU 76 – Unveiling Nutritional Deficiencies in Aging: A Closer Look at Vitamin D, B12, and More

NMU 76 – Vitamin Deficiencies Common in Aging: How to identify them and prevent consequences

Lifestyle Medicine Update (December 20, 2017)

Introduction

As the pages of time turn and we venture into the realm of aging, an illuminating study beckons our attention, shedding light on the profound impact of nutritional deficiencies on our golden years. Published in the journal Nutrients in 2017, this study delves into the lives of an aging population in southern Germany, uncovering startling revelations about the prevalence of sub-optimal levels of essential micronutrients such as vitamin D, B12, iron, and folate. In this exploration, we unearth the significance of these deficiencies, their consequences, and the empowerment that lies within annual blood tests.

The Aging Enigma: Unveiling the KORA-Age Study

Encompassing the canvas of aging, the KORA-Age Study embarked on a mission to scrutinize the lives of 1,079 older adults, spanning from ages 65 to 93 years. This remarkable endeavor, undertaken by the KORA Cooperative Health Research platform, delved into the depths of four vital micronutrients – vitamin D, folate, vitamin B12, and iron. What emerged from this canvas of investigation was a tapestry of revelations, illuminating the prevalence of sub-optimal levels of these micronutrients in the aging populace.

Unmasking Vitamin D Insufficiency

The spotlight turns to vitamin D, a renowned ally in the battle against a myriad of ailments, from cancer to osteoporosis and diabetes. The study cast a revealing light, showcasing that over 50% of the examined older adults bore blood levels of vitamin D below 50 nmol/L, indicating a suboptimal status. This finding strikes a chord, considering the recommended level for optimal prevention stands at 75 nmol/L or higher. The research resonates as a cautionary tale, hinting at the need to address this prevalent deficiency to safeguard against the ravages of various health maladies.

Vitamin B12: A Memory’s Guardian

Vitamin B12, a sentinel for memory and cognition, takes center stage. The study unfurls a disconcerting truth – 27% of the elderly subjects bore blood levels of vitamin B12 below the established threshold. Beyond its role in preventing anemia, vitamin B12 wields its influence in the realms of memory and cognitive function. Its absence can unleash memory loss and dementia-related symptoms, as B12 plays a pivotal role in crafting brain neurotransmitters crucial for memory retention. This revelation underscores the imperative of addressing this deficiency early to preserve cognitive prowess and stave off the shadows of memory loss.

Folate and Iron: Guardians of Vitality

Folate and iron, unassuming yet vital players, unfurl their significance on this stage. The study exposes the sobering truth – 9% of participants grappled with low folate levels, while 11% bore the burden of low iron levels. These deficiencies are harbingers of subtle yet impactful consequences. Folate and vitamin B12 deficiencies herald memory loss and cognitive impairment, disrupting the delicate equilibrium of brain health. Iron, even in its marginal scarcity, can sow the seeds of low energy, memory lapses, concentration struggles, and weakened resistance to infections. These findings serve as a clarion call to address these deficiencies to preserve vitality and overall well-being.

Annual Blood Tests: A Beacon of Empowerment

In the realm of health, knowledge is power, and annual blood tests stand as the beacon of this empowerment. The study underscores the value of monitoring blood levels of these essential micronutrients. It beckons individuals to advocate for themselves, urging them to request comprehensive tests during their annual physical exams. While some insurance plans might not cover tests for vitamin D or homocysteine, their impact on health is immeasurable. The revelations these tests unveil provide a roadmap to potential future diseases, spurring individuals to take charge of their well-being.

The Path Forward: Nurturing Optimal Health

In the grand tapestry of life, aging is a chapter that deserves to be written with vibrancy, vitality, and resilience. The study’s findings echo a universal truth – to nurture health and well-being, one must be proactive. Regular monitoring of blood levels, particularly for vitamin D, B12, folate, iron, and homocysteine, holds the key to longevity and disease-free living. Armed with this knowledge, individuals can embrace the journey ahead with the assurance that their bodies and minds are fortified against the challenges of time.

Conclusion

As the curtain falls on the pages of this study, a narrative of empowerment emerges. The echoes of deficiency dissolve into the promise of proactive measures. The insights gained from this study transcend mere numbers, resonating as a call to action for all seeking a vibrant and thriving life. With the tapestry of aging before us, armed with the knowledge gleaned from annual blood tests, we can navigate the journey with vitality and resilience, embracing each chapter with the grace of well-nourished minds and bodies.

References

  1. Conzade R, et al. Prevalence and Predictors of Subclinical Micronutrient Deficiency in German Older Adults: Results from the Population-Based KORA-Age Study. Nutrients 2017, 9(12), 1276
  2. [Link to the Study] (http://www.mdpi.com/2072-6643/9/12/1276)

Eat Smart, Live Well, Look Great,

Dr. Meschino

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

Adeeva Supplements